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Shell membrane protein system in relation to lathyrogen toxicity and copper deficiency

Published online by Cambridge University Press:  23 March 2009

S.D. Chowdhury
S.D. Chowdhury
Affiliation:
Division of Biochemistry and Physiology, Wye College, University of London, Wye, Ashford, Kent TN25 5AH, UK
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Abstract

A chronological account of observations on the nature of the shell membrane protein system is presented. The review indicates that although the major protein in the shell membrane is not elastin, it does contain desmosine and isodesmosine – the cross-linking amino acids. The membranes also contain small amounts of collagen. The formation of these proteins can be impaired by the inclusion of lathyrogens in the diet of laying hens. This impairment is caused by a failure to synthesize cross-links of membrane protein and this is very similar to the effect obtained when hens are fed copper-deficient diets. The disruption of the protein system has a considerable effect on the development of eggs, which are abnormal in size, shape and shell texture. The lathyrogens also have a depressing effect on egg production. The problems and prospects of utilizing seeds of certain Lathyrus plants containing lathyrogens are indicated.

Keywords

Abnormalcoppereggshelllathyrogenmembranenutritionproteintoxicityβ-aminoproprionitrilesemi-carbazide
Type
Reviews
Information
World's Poultry Science Journal , Volume 46 , Issue 2 , July 1990 , pp. 153 - 169
Copyright
Copyright © Cambridge University Press 1990

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References

Baker, J.R. and Balch, D.A. (1962) A study of the organic material of hen's eggshell. Biochemical Journal 82: 352–361CrossRefGoogle Scholar
Balch, D.A. and Cooke, R.A. (1970) A study of the composition of hen's egg-shell membranes. In: Symposium on the Physiology of the Egg-shell Formation. Annales de biologie animale biochimie biophysique 10 (extra no. 2): 13–25Google Scholar
Bannister, D.W.Candlish, J.K. and Freeman, H. (1971) Some effects of feeding lathyrogens to laying fowls. British Poultry Science 12: 129–136CrossRefGoogle ScholarPubMed
Barnett, B.D., Richey, D.J. and Morgan, C.L. (1957) Effect of beta-aminopropionitrile on reproduction of chickens. Proceedings of the Society of Experimental Biology and Medicine 95: 101–104CrossRefGoogle ScholarPubMed
Barrow, M.V., Simpson, C.F. and Miller, E.J. (1974) Lathyrism: a review. Quarterly Review of Biology 49: 101–128CrossRefGoogle ScholarPubMed
Baumgartner, S., Brown, D.J., Salevsky, E. Jr and Leach, R.M. Jr (1978) Copper deficiency in the laying hen. Journal of Nutrition 108: 804–811CrossRefGoogle ScholarPubMed
Bellairs, R. and Boyde, A. (1969) Scanning electron microscopy of the shell membranes of the hen's egg. Zeitschrift für Zellforschung 96: 237–249CrossRefGoogle ScholarPubMed
Blackwood, U.B. and Naber, E.C. (1963) Modification of beta-aminopropionitrile toxicity by divalent metal salts in the chick embryo. Poultry Science 42: 782–784CrossRefGoogle Scholar
Calvery, H.O. (1933) Some analyses of eggshell keratin. Journal of Biological Chemistry 100: 183–186CrossRefGoogle Scholar
Candlish, J.K. (1970) The outer membrane of the avian egg shell as a reticular structure. British Poultry Science 11: 341–344CrossRefGoogle Scholar
Candlish, J.K. (1972) The role of the shell membranes in the functional integrity of the egg. In: Egg Formation and Production (Eds Freeman, B.M. and Lake, P.E.) British Poultry Science Ltd, Edinburgh, UK, pp. 87–105Google Scholar
Candlish, J.K. and Scougall, R.K. (1969) L-5-hydroxylysine as a constituent of the shell membranes of the hen's egg. International Journal of Protein Research 1: 299–302CrossRefGoogle ScholarPubMed
Chowdhury, S.D. (1987) Effects of feeding osteolathryrogens to laying fowls (Gallus domesticus) with particular reference to eggshell and membrane quality. PhD Thesis, University of London, UKGoogle Scholar
Chowdhury, S.D. (1988) Lathyrism in poultry – a review. World's Poultry Science Journal 44: 7–16CrossRefGoogle Scholar
Chowdhury, S.D.Effects of low and high dietary levels of beta-aminopropionitrile (BAPN) on the performance of laying chickens. Journal of the Science of Food and Agriculture, in pressGoogle Scholar
Chowdhury, S.D. and Davis, R.H. (1988) Lathyrism in the laying hen and increases in egg weight. Veterinary Record 123: 272–275CrossRefGoogle Scholar
Chowdhury, S.D. and Davis, R.H. (1989) Comparison of the effects of two lathyrogens on the reproductive system of the laying hen. Veterinary Record 124: 240–242CrossRefGoogle ScholarPubMed
Cooke, A.S. and Balch, D.A. (1970) Studies of membrane, mammilary cores and cuticle of the hen egg shell. British Poultry Science 11: 345–352CrossRefGoogle Scholar
Crombie, G., Snider, R., Faris, B. and Franzblau, C. (1981) Lysine-derived cross-links in the egg-shell membrane. Biochimica et Biophysica Acta 640: 365–367CrossRefGoogle ScholarPubMed
El Boushy, A.R. and Raterink, R. (1985) Eggshell strength: the causes of egg breakage in relation to nutrition, management and environment. Feedstuffs 57 (33): 18–22; (34) 7–9Google Scholar
Essary, E.O., Sheldon, B.W. and Crews, S.L. (1977) Relationship between shell and shell membrane strength and other eggshell characteristics. Poultry Science 56: 1882–1888CrossRefGoogle Scholar
Fujii, S. and Tamura, T. (1970) Scanning electron microscopy of shell formation in hen's eggs. Journal of the Faculty of Fisheries and Animal Husbandry, Hiroshima University 9: 65–81Google Scholar
Fujii, S., Watari, T. and Tamura, T. (1980) Scanning of electron microscopy on the structure of abnormal hen's eggshell. Journal of the Faculty of Applied Biological Science, Hiroshima University 19: 101–111Google Scholar
Gross, J., Charles, I.L. and Orloff, S. (1960) Fragility and extractable collagen in the lathyritic chick embryo. An assay for lathyrogenic agents. Proceedings of the Society of Experimental Biology and Medicine 105: 148–151CrossRefGoogle ScholarPubMed
Harris, E.D. (1986) Biochemical defect in chick lung resulting from copper deficiency. Journal of Nutrition 116: 252–258CrossRefGoogle ScholarPubMed
Harris, E.D., Blount, J.E. and Leach, R.M. Jr (1980) Localization of lysyl oxidase in hen oviduct: implications in egg shell formation and composition. Science 208: 55–56CrossRefGoogle ScholarPubMed
Hodges, R.D. (1974) Histology of the Fowl, Academic Press, London, UKGoogle Scholar
Hoffer, A.P. (1971) The ultrastructure and cytochemistry of the shell membrane–secreting region of the Japanese Quail oviduct. American Journal of Anatomy 131: 253–288CrossRefGoogle ScholarPubMed
Kim, C.S. and Hill, C.H. (1966) The interrelationship of dietary copper and amine oxidase in the formation of elastin. Biochemical and Biophysical Research Communications 24: 395–400CrossRefGoogle ScholarPubMed
Lalich, J.J., Barnett, B.D. and Bird, H.R. (1957) Production of aortic rupture in turkey poults fed beta-aminopropiontrile. American Medical Association Archives of Pathology 64: 643–648Google Scholar
Leach, R.M. Jr (1982) Biochemistry of the organic matrix of the eggshell. Poultry Science 61: 2040–2047CrossRefGoogle Scholar
Leach, R.M. Jr, and Rucker, R.B. (1978) Studies on the major protein component of egg shell membranes. Poultry Science 57: 1151Google Scholar
Leach, R.M. Jr, Rucker, R.B. and Van Dyke, G.P. (1981) Egg shell membrane protein: a nonelastin desmosine/isodesmosine containing protein. Archives of Biochemistry and Biophysics 207: 353–359CrossRefGoogle ScholarPubMed
Levene, C.I. and Gross, J. (1959) Alterations in state of molecular aggregation of collagen induced in chick embryos by β-aminopropionitrile (Lathyrus factor). Journal of Experimental Medicine 110: 771–790CrossRefGoogle ScholarPubMed
MAFF (Ministry of Agriculture, Fisheries and Food) (1982) Quality Testing of Eggs Revised Edn., Her Majesty's Stationery Office, London, UKGoogle Scholar
Masshoff, W. and Stolpmann, H.J. (1961) Licht-und elektronmikroskopische Untersuchungen an der Schalenhaut und Kalkschale des Huhnereis. Zeitschrift für Zellforschung 55: 818–832CrossRefGoogle Scholar
Naber, E.C. and Sunde, M.L. (1965) The effect of beta-aminopropionitrile on calcium metabolism in the laying hen. Poultry Science 44: 1402CrossRefGoogle Scholar
Naber, E.C., Scott, K. and Johnson, R.M. (1967) Relationships of divalent cations to experimental lathyrism and collagen formation. Federation Proceedings 26: 121–128Google ScholarPubMed
Nesheim, M.C.Austic, R.E. and Card, L.E. (1979) Poultry Production 12th Edn., Lea and Febiger, Philadelphia, USAGoogle Scholar
O'Dell, B.L., Elsden, D.F., Thomas, J., Partridge, S.M., Smith, R.H. and Palmer, R. (1966) Inhibition of the biosynthesis of the cross-links in elastin by a lathyrogen. Nature 209: 401–402CrossRefGoogle ScholarPubMed
Roy, D.N. (1981) Toxic amino acids and proteins from Lathyrus plants and other leguminous species: a literature review. Nutrition Abstracts and Review Series A 51: 691–707Google Scholar
Savage, J.E., Ross, D.A., Reynolds, G. and O'Dell, B.L. (1962) Copper deficiency and ß-aminopropionitrile toxicity in kidneys. Federation Proceedings 21: 311–312Google Scholar
Selye, H. (1957) Lathyrism. Revue Canadienne de Biologie 16: 1–82Google ScholarPubMed
Siegel, R.C.Pinnell, S.R. and Martin, G.R. (1970) Cross-linking of collagen and elastin. Properties of lysyl oxidase. Biochemistry 9: 4486–4492CrossRefGoogle ScholarPubMed
Simkiss, K. (1958) The structure of the eggshell with particular reference to the hen. PhD Thesis, University of Reading, UKGoogle Scholar
Simkiss, K. (1968) The structure and formation of the shell and shell membranes. In: Egg Quality: A Study of the Hen's Egg (Ed. Carter, T.C.) Oliver and Boyd, Edinburgh, UK, pp. 3–25Google Scholar
Simons, P.C.M. (1971) Ultrastructure of the hen eggshell and its physiological interpretation Communication No. 175, Central Institute for Poultry Research ‘Het Spelderholdt’, Beekbergen, The NetherlandsGoogle Scholar
Simons, P.C.M. and Wiertz, G. (1963) Notes on the structure of membranes and shell in the hen's egg. An electron microscopical study. Zeitschrift für Zellforschung 59: 555–567CrossRefGoogle Scholar
Simons, P.C.M. and Wiertz, G. (1970) Notes on the structure of shell and membranes of hen's egg; a study with the scanning electron microscope. In: Symposium on the Physiology of the Egg-shell Formation. Annales de Biologie Animale, Biochemie, Biophysique 10 (extra No. 2) 31–49Google Scholar
Solomon, S.E. (1987) Eggshell pigmentation. In: Egg Quality. Current Problems, Recent Advances (Eds Wells, R.G. and Belyavin, C.G.) Butterworth, London, UK, pp. 147–157Google Scholar
Tanzer, M.L. (1973) Cross-linking of collagen. Science 180: 561–566CrossRefGoogle ScholarPubMed
Taylor, T.G. (1970) How an eggshell is made. Scientific American 222: 89–95CrossRefGoogle Scholar
Terepka, A.R. (1963) Structure and calcification in avian eggshell. Experimental Cell Research 30: 171–182CrossRefGoogle Scholar
Tullet, S.G. (1987) Eggshell formation and quality. In: Egg Quality. Current Problems, Recent Advances (Eds Wells, R.G. and Belyavin, C.G.) Butterworth, London, UK, pp. 123–146Google Scholar
Tung, M.A. (1970) Physical, chemical and rheological studies of the hen's egg. PhD Thesis, University of British Columbia, CanadaGoogle Scholar
Tyler, C. and Simkiss, K. (1959) Studies on eggshells. Some abnormalities. Journal of the Science of Food and Agriculture 10: 362–366CrossRefGoogle Scholar
Van Den Hoff, A., Levene, C.I. and Gross, G. (1959) Morphologic evidence for collagen changes in chick embryos treated with ß-aminopropionitrile. Journal of Experimental Medicine 110: 1017–1027CrossRefGoogle Scholar
Washburn, K.W. (1982) Incidence, cause, prevention of egg shell breakage in commercial production. Poultry Science 61: 2005–2012CrossRefGoogle Scholar
Wolken, J.J. (1951) Structure of the hen's egg membranes. Anotomical Record 111: 79–89CrossRefGoogle ScholarPubMed
Wong, M., Hendrix, M.J.C., Von Der Mark, K., Little, C. and Stern, R. (1984) Collagen in the egg shell membranes of the hen. Developmental Biology 104: 28–36CrossRefGoogle ScholarPubMed
Youtz, S.L., Packard, M.J. and Leach, R.M. Jr, (1984) Total desmosine content in the organic matrix of various avian and reptile eggs. Comparative Biochemistry and Physiology 77B: 27–29Google Scholar