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Unsound Methodology in Investigating a Pseudoautosomal Locus in Schizophrenia

Published online by Cambridge University Press:  02 January 2018

David Curtis  and
Hugh Gurling
David Curtis*
Affiliation:
University College and Middlesex School of Medicine, Wolfson Building, Middlesex Hospital, Riding House Street, London W1N 8AA
Hugh Gurling
Affiliation:
University College and Middlesex School of Medicine, Wolfson Building, Middlesex Hospital, Riding House Street, London W1N 8AA
*
∗Correspondence
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Extract

We have reservations about accepting the conclusions made by Crow et al (1989), namely that there is evidence that susceptibility to schizophrenia may be transmitted by a pseudoautosomal locus. In our view the methodology of the study is unsound. Additionally the data presented by the authors, when analysed correctly, do not support their hypothesis.

Type
Points of View
Information
The British Journal of Psychiatry , Volume 156 , Issue 3 , March 1990 , pp. 415 - 416
Copyright
Copyright © Royal College of Psychiatrists, 1990 

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References

Crow, T. J., DeLisi, L. E. & Johnstone, E. C. (1989) Concordance by sex in sibling pairs with schizophrenia is paternally inherited –Evidence for a pseudoautosomal locus. British Journal of Psychiatry, 155, 92–97.CrossRefGoogle ScholarPubMed
Sturt, E. & Shur, E. (1985) Sex concordance for schizophrenia in proband-relative pairs. British Journal of Psychiatry, 147, 44–47.CrossRefGoogle ScholarPubMed
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