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The Dynamics of Complex Biological-Psychosocial Systems

Four Fundamental Psycho-Biological Mediators in the Long-term Evolution of Schizophrenia

Published online by Cambridge University Press:  06 August 2018

Luc Ciompi
Luc Ciompi*
Affiliation:
Sozialpsychiatrische Universitätsklinik, Bern
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Extract

The scope of this introductory contribution is to present some general facts and ideas which could enhance our understanding of this enigmatic illness. By ‘mediating processes’ (or ‘mediators’) I mean mechanisms providing bridges between different aspects of knowledge of the schizophrenia-puzzle which, so far, have not been linked together in a satisfactory way: one of the central problems is the identification of mediators between psychosocial factors on the one hand, and biological factors on the other. If we do not succeed in building up conceptually valid bridges between these two aspects, which are testable for hypothesis-orientated research, a disastrous splitting of our understanding and treatment of schizophrenia into either biological or psychosocial reductionism is likely.

Type
I. Introduction: Unfolding of the Area
Information
The British Journal of Psychiatry , Volume 155 , Issue S5: Schizophrenia as a Systems Disorder: The Relevance of Mediating Processes for Theory and Therapy , July 1989 , pp. 15 - 21
Copyright
Copyright © The Royal College of Psychiatrists 

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References

Allen, P. M., G., Engelen. & Sanglier, M. (1986) Self-organizing systems and the “laws of socio-economic geography”. European Journal of Operational Research, 25, 177–140.Google Scholar
Babloyantz, A. (1986) Molecules, Dynamics and Life. An Introduction to Selforganization of Matter. New York: Wiley.Google Scholar
Bateson, G., Jackson, D. D., Haley, J., et al. (1956) Auf dem Weg zu einer Schizophrenie-Theorie. In Schizophrenie und Familie (eds Habermas, J., Henri, D. & Taubes, J.). Frankfurt: Suhrkamp.Google Scholar
Bleuler, M. (1972) Die schizophrenen Geistesstörungen im Lichte langjähriger Kranken- und Familiengeschichten. Stuttgart: Thieme.Google Scholar
Bleuler, M. (1984) Das alte und das neue Bild des Schizophrenen. Schweizer Archiv für Neurologie, Neurochirurgie und Psychiatrie, 135, 143–149.Google Scholar
Brown, G. W. & Birley, L. T. (1970) Crisis and Life Changes and the Onset of Schizophrenia. London: Cambridge University Press.Google Scholar
Brown, G. W. & Birley, L. T. (1972) Influence of family life on the course of schizophrenic disorders: A replication. British Journal of Psychiatry, 121, 241–258.Google Scholar
Ciompi, L. (1980a) The natural history of schizophrenia in the long-term. British Journal of Psychiatry, 136, 413–420.CrossRefGoogle ScholarPubMed
Brown, G. W. (1980b) Catamnestic long-term studies on the course of life of schizophrenics. Schizophrenia Bulletin, 6, 606–618.Google Scholar
Brown, G. W. (1981) Wie können wir die Schizophrenen besser behandeln? Ein neues Krankheits- und Therapiekonzept. Nervenarzt, 52, 506–515.Google Scholar
Brown, G. W. (1982) Affektlogik. Ueber die Struktur der Psyche und ihre Entwicklung. Ein Beitrag zur Schizophrenieforschung. Stuttgart: Klett-Cotta. (Published in English (1988) The Psyche and Schizophrenia. The Bound between Affect and Logic . Cambridge, Massachusetts: Harvard University Press).Google Scholar
Brown, G. W. (1984) Modellvorstellungen zum Zusammenwirken biologischer und psychologischer Faktoren in der Schizophrenie. Fortschritte der Neurologie und Psychiatrie, 52, 191–222.Google Scholar
Brown, G. W. (1987) Toward a coherent multidimensional understanding and therapy of schizophrenia: Converging new concepts. In Psychosocial Treatment of Schizophrenia (eds Strauss, J. S., Böker, W. & Brenner, H. D.). Bern: Huber.Google Scholar
Brown, G. W. (1988) Learning from outcome studies: Toward a comprehensive biological-psychosocial understanding of schizophrenia. Schizophrenia Research, 1, 373–384.Google Scholar
Brown, G. W. & Müller, C. (1976) Lebensweg und Alter der Schizophrenen. Eine katamnestische Langzeitstudie. Heidelberg: Springer.Google Scholar
Brown, G. W. & Bernasconi, R. (1986) “Soteria” Bern. Erste Erfahrungen mit einer neuartigen Milieutherapie für akute Schizophrene. Psychiatrische Praxis, 13, 172–176.Google Scholar
Brown, G. W., Dauwalder, H.-P. & Ague, C. (1979) Ein Forschungsprogramm über die Rehabilitation psychisch Kranker. III. Längsschnittuntersuchung zum Rehabilitationserfolg und zur Prognostik. Nervenarzt, 50, 366–378.Google Scholar
Cooper, B. (1980) Die Rolle von Lebensereignissen bei der Entstehung psychischer Störungen. Nervenarzt, 51, 321–331.Google Scholar
Dauwalder, H.-P., Ciompi, L., Aebi, E. et al. (1984) Ein Forschungsprogramm zur Rehabilitation psychisch Kranker IV. Nervenarzt, 55, 257–264.Google Scholar
Dell, P. F. & Goolishan, H. A. (1981) Ordnung durch Fluktuation. Eine evolutionäre Epistemologie für menschliche Systeme. Familiendynamik, 6, 104–122.Google Scholar
Destexhe, A. (1984-1985) Restitution de la dynamique de l'activité cérébrale épileptique. Bruxelles: Université Libre de Bruxelles (Dissertation), Année Académique.Google Scholar
Dohrenwendt, W. P. & Egri, G. (1981) Recent stressful life events and episodes of schizophrenia. Schizophrenia Bulletin, 7, 12–23.Google Scholar
Elkaim, M., Goldbeter, A. & Goldbeter, E. (1980) Analyse des transactions de comportement dans un système familial en termes de bifurcation. Cahiers Critiques de Thérapie Familiale et de Pratique des Réseaux, 3, 18–34.Google Scholar
Gjerde, F. (1983) Attentional capacity dysfunction and arousal in schizophrenia. Psychological Bulletin, 93, 57–72.CrossRefGoogle ScholarPubMed
Goldstein, M. J. (1987) Psychosocial issues. Schizophrenia Bulletin, 13, 157–171.Google Scholar
Gruzelier, J. H. (1978) Bimodal plates of arousal and lateralized dysfunction in schizophrenia. In The Nature of Schizophrenia (eds Wynne, L. C., Cromwell, R. & Matthysse, S.). New York: Wiley.Google Scholar
Haracz, J. L. (1982) The dopamine hypothesis: An overview of studies with schizophrenic patients. Schizophrenia Bulletin, 8, 438–469.Google Scholar
Haracz, J. L. (1984) A neural plasticity hypothesis of schizophrenia. Neuroscience and Behavioral Reviews, 8, 55–71.CrossRefGoogle ScholarPubMed
Haracz, J. L. (1985) Neural plasticity in schizophrenia. Schizophrenia Bulletin, 11, 191–229.Google Scholar
Harding, C. M., Brooks, G. W., Ashikaga, T., Strauss, J. S. & Breier, A. (1987a) The Vermont longitudinal study of persons with severe mental illness. I. Methodology study sample, and overall status 32 years later. American Journal of Psychiatry, 144, 718–726.Google Scholar
Harding, C. M., Brooks, G. W., Ashikaga, T., Strauss, J. S. & Breier, A. (19876) The Vermont longitudinal study of persons with severe mental illness. II. Long-term outcome of subjects who retrospectively met DSM-III criteria for schizophrenia. American Journal of Psychiatry, 144, 727–735.Google Scholar
Hirsch, S. (1979) Eltern als Verursacher der Schizophrenic Der wissenschaftliche Stand einer Theorie. Nervenarzt, 50, 337–345.Google Scholar
Huber, G., Gross, G. & Schüttler, R. (1979) Schizophrenie. Eine verlaufs- und sozialpsychiatrische Studie. Berlin: Springer.Google Scholar
King, R. & Barchas, J. D. (1983) An application of dynamic systems theory to human behavior. In Synergetics of the Brain (eds Basar, E., Flohr, H., Haken, H. & Handell, A. I.). Berlin: Springer.Google Scholar
Leff, J. P., Kuipers, L., Berkowitz, R., et al. (1982) A controlled trial of social intervention in the families of schizophrenic patients. British Journal of Psychiatry, 141, 121–134.CrossRefGoogle ScholarPubMed
Lempp, R. (1973) Psychosen im Kindes- und Jugendalter – eine Realitatsbezugssttörung . Bern: Huber.Google Scholar
Matthysse, S. (1978) A theory of the relation between dopamine and selective attention. Journal of Psychiatric Research, 14, 241–248.Google Scholar
McCulloch, M. J. & Waddington, J. L. (1979) Catastrophe theory: A model interaction between neurochemical and environmental influences in the control of schizophrenia. Neuropsychobiology, 5, 87–93.Google Scholar
Meltzer, H. Y. (1987) Biological studies in schizophrenia. Schizophrenia Bulletin, 13, 77–111.Google Scholar
Nicolis, C. (1983) Thermodynamique de l'évolution. In Evolution (ed. Reisse, J.). Bruxelles: Editions de l'Université Libre de Bruxelles.Google Scholar
Nicolis, C. (1984) L'écart à l'équilibre, source de comportements complexes de la matière. Nouvelles de la Science et des Technologies, 2, 11–15.Google Scholar
Prigogine, I. & Stengers, I. (1984) Order out of Chaos. New York: Bantam.Google Scholar
Purves, D. & Hadley, R. D. (1985) Changes in the dendritic branching of adult mammalian neurones revealed by repeated imaging in situ. Nature, 315, 404–406.Google Scholar
Selye, H. (1950) The Physiology and Pathology of Exposure to Stress. Montreal: Acta Inc.Google Scholar
Selye, H. (1954) Einführung in die Lehre vom Adaptationssyndrom. Stuttgart: Thieme.Google Scholar
Singer, M. T., Wynne, L. C. & Toohey, B. A. (1978) Communication disorders in the families of schizophrenics. In The Nature of Schizophrenia (eds Wynne, L. C., Cromwell, R. L. & Matthysse, S.). New York: Wiley.Google Scholar
Thierry, A. M., Tassin, J. P., Blanc, G., et al (1977) Discovery of the mesocortical dopaminergic system: Some pharmacological and functional characteristics. Advances in Biochemical Psychopharmacology, 16, 5–12.Google Scholar
Thom, R. (1915) Structural Stability and Morphogenesis. London: Addison-Wesley.Google Scholar
Tienari, P., Sorri, A., Lathi, I., et al (1985) Interaction of genetic and psychosocial factors in schizophrenia. Acta Psychiatrica Scandinavica, 71 (Suppl. 319), 19–30.Google Scholar
Trulson, M. E. & Preussler, D. W. (1984) Dopamine-containing ventral tegmental area neurons in freely moving cats: Activity during the sleep-waking cycle and effects of stress. Experimental Neurology, 83, 367–377.Google Scholar
Vaughn, C. & Leff, J. (1976) The measurement of expressed emotion in the families of psychiatric patients. British Journal of Social and Clinical Psychology, 15, 157–165.Google Scholar
Wing, J. K. & Brown, G. W. (1971) Institutionalism and Schizophrenia. London: Cambridge University.Google Scholar
Zubin, J. & Spring, B. (1977) Vulnerability – a new view on schizophrenia. Journal of Abnormal Psychology, 86, 103–126.Google Scholar
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