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Accepted manuscript

Ultra-processed food intake, genetic polymorphisms, and the risk of dyslipidemia in the adult Korean population

Published online by Cambridge University Press:  10 February 2025

Minsu Cho ,
Heejin Lee  and
Jung Eun Lee Open the ORCID record for Jung Eun Lee [Opens in a new window]
Minsu Cho
Affiliation:
Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 08826, Korea
Heejin Lee
Affiliation:
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA
Jung Eun Lee*
Affiliation:
Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 08826, Korea The Research Institute of Human Ecology, Seoul National University, Seoul 08826, Korea
*
Corresponding author: Jung Eun Lee, Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 08826, Korea, Email: [email protected], Tel: +82-2-880-6834
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Abstract

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Objective:

This study aimed to examine the association between ultra-processed food intake and dyslipidemia risk, and whether this association varied by the polygenic score for dyslipidemia in the adult Korean population.

Design:

Prospective cohort study

Setting:

Ultra-processed foods were identified under the NOVA classification. Participants were categorized into <5, 5 to <10, 10 to <15, 15 to <20, and ≥20%E/d of ultra-processed food intake. The polygenic scores for dyslipidemia were calculated from 53,950 single nucleotide polymorphisms. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multivariate logistic regression models.

Participants:

20,044 Korean adults aged ≥40 years in the Health Examinees (HEXA) study, the Cardiovascular Disease Association Study (CAVAS), and the Korea Association Resource (KARE) study

Results:

During median follow-ups of 4.09, 8.67, and 15.67 years in the HEXA, CAVAS, and KARE studies, respectively, there were a total of 7,331, 786, and 1,732 incident dyslipidemia events. Ultra-processed food intake was not significantly associated with dyslipidemia risk. Compared with <5%E/d, the pooled OR (95% CI) of ≥20%E/d of ultra-processed food intake for dyslipidemia incidence was 1.01 (0.90, 1.13; p for trend=0.83). There was no interaction by dyslipidemia-related genetic variations; ORs (95% CIs) were 1.04 (0.89, 1.22; p for trend=0.91) and 0.98 (0.84, 1.15; p for trend=0.72) for individuals with high and low polygenic scores, respectively (p for interaction=0.90).

Conclusions:

No significant association was observed between ultra-processed food intake and the overall risk of dyslipidemia, nor in subgroups of polygenic scores for dyslipidemia among Korean adults with low ultra-processed food intake.

Keywords

Ultra-processed fooddyslipidemiapolygenic scoresingle nucleotide polymorphism
Type
Research Paper
Information
Public Health Nutrition , Accepted manuscript , pp. 1 - 23
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
Copyright
© The Authors 2025