Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-11-23T03:35:08.726Z Has data issue: false hasContentIssue false
  • English
  • Français

Serum ferritin, cardiovascular risk factors and ischaemic heart diseases: a prospective analysis in the SU.VI.MAX (SUpplementation en VItamines et Minéraux AntioXydants) cohort

Published online by Cambridge University Press:  02 January 2007

Pilar Galan ,
Nathalie Noisette ,
Carla Estaquio ,
Sebastien Czernichow ,
Louise Mennen ,
Jean-Charles Renversez ,
Serge Briançon ,
Alain Favier  and
Serge Hercberg
Pilar Galan*
Affiliation:
U557 INSERM (UMR INSERM/INRA/CNAM), Centre de Recherche en Nutrition, Ile de France, Paris 13, Bobigny, France
Nathalie Noisette
Affiliation:
U557 INSERM (UMR INSERM/INRA/CNAM), Centre de Recherche en Nutrition, Ile de France, Paris 13, Bobigny, France
Carla Estaquio
Affiliation:
U557 INSERM (UMR INSERM/INRA/CNAM), Centre de Recherche en Nutrition, Ile de France, Paris 13, Bobigny, France
Sebastien Czernichow
Affiliation:
U557 INSERM (UMR INSERM/INRA/CNAM), Centre de Recherche en Nutrition, Ile de France, Paris 13, Bobigny, France
Louise Mennen
Affiliation:
U557 INSERM (UMR INSERM/INRA/CNAM), Centre de Recherche en Nutrition, Ile de France, Paris 13, Bobigny, France
Jean-Charles Renversez
Affiliation:
Département de Biologie Intégrée, CHU de Grenoble, France
Serge Briançon
Affiliation:
Ecole de Santé Publique, Epidémiologie clinique, Faculté de Médecine, CHU Nancy EA 3444, France
Alain Favier
Affiliation:
Département de Biologie Intégrée, CHU de Grenoble, France Laboratoire Lésions des Acides Nucléiques, UMR CNRS-CEA-UJF 5046, Grenoble, France
Serge Hercberg
Affiliation:
U557 INSERM (UMR INSERM/INRA/CNAM), Centre de Recherche en Nutrition, Ile de France, Paris 13, Bobigny, France Unité de Surveillance et d'Epidémiologie Nutritionnelle, INVS/CNAM, Paris, France
*
*Corresponding author: Email [email protected]
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Background

Iron has been suggested to play a role in the development of cardiovascular disease (CVD) through its pro-oxidant properties. However, epidemiological studies on iron status and the risk of CVD have yielded conflicting results. We therefore carried out a prospective study to evaluate the relationship between iron status and CVD in a middle-aged French population.

Methods

In total, 9917 subjects (3223 men aged 45–60 years and 6694 women aged 35–60 years) included in the SU.VI.MAX (SUpplementation en VItamines et Minéraux AntioXydants) cohort were followed prospectively for 7.5 years. All cases of ischaemic heart disease (IHD) were identified and validated. CVD risk factors, haemoglobin and serum ferritin concentrations were measured at baseline.

Findings

Of men 4.3%, and of women 37.8%, presented at baseline a serum ferritin concentration <30 μg l−1. During the follow-up, 187 subjects (148 men, 39 women) developed IHD. Serum ferritin was positively associated with total cholesterol, serum triglycerides, systolic and diastolic blood pressure, body mass index and haemoglobin. No linear association was found between serum ferritin and IHD risk in men or in women.

Conclusion

Our data do not support a major role of iron status in the development of IHD in a healthy general population.

Keywords

IronSerum ferritinIschaemic heart diseaseProspective study
Type
Research Article
Information
Public Health Nutrition , Volume 9 , Issue 1 , February 2006 , pp. 70 - 74
Copyright
Copyright © The Authors 2006

References

1Halliwell, B, Gutteridge, JMC. Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts. Archives of Biochemistry and Biophysics 1986; 246: 501–14.CrossRefGoogle ScholarPubMed
2Sempos, CT, Looker, AC, Gillum, RF. Iron and heart disease: the epidemiologic data. Nutrition Reviews 1996; 54: 73–84.CrossRefGoogle ScholarPubMed
3Meyers, DG. The iron hypothesis: does iron cause atherosclerosis?. Clinical Cardiology 1996; 19: 925–9.CrossRefGoogle ScholarPubMed
4Sempos, CT. Do body iron stores increase the risk of developing coronary heart disease?. American Journal of Clinical Nutrition 2002; 76: 501–3.CrossRefGoogle ScholarPubMed
5Ma, J, Stampfer, MJ. Body iron stores and coronary heart disease. Clinical Chemistry 2002; 48: 601–3.CrossRefGoogle ScholarPubMed
6Cook, JD, Lipschitz, DA, Miles, LE, Finch, CA. Serum ferritin as a measure of iron stores in normal subjects. American Journal of Clinical Nutrition 1974; 27: 681–7.CrossRefGoogle ScholarPubMed
7Bozzini, C, Girelli, D, Yinazzi, E, Olivieri, O, Stranieri, C, Bassi, A, et al. Biochemical and genetic markers of iron status and the risk of coronary artery disease: an angiography-based study. Clinical Chemistry 2002; 48: 622–8.CrossRefGoogle ScholarPubMed
8Sempos, CT, Looker, AC, Gillum, RE, McGee, DL, Vuong, CV, Johnson, CL. Serum ferritin and death from all causes and cardiovascular disease: the NHANES II Mortality Study. National Health and Nutrition Examination Study. Annals of Epidemiology 2000; 10: 441–8.CrossRefGoogle ScholarPubMed
9Aronow, WS. Serum ferritin is not a risk factor for coronary artery disease in men and women aged >62 years. American Journal of Cardiology 1993; 72: 347–8.CrossRefGoogle ScholarPubMed
10Solymoss, BC, Marcil, M, Gilfix, BM, Gelinas, F, Poitras, AM, Campeau, L. The place of ferritin among risk factors associated with coronary artery disease. Coronary Artery Disease 1994; 5: 231–5.CrossRefGoogle ScholarPubMed
11Rauramaa, R, Väisänen, S, Mercuri, M, Rankinen, T, Penttila, I, Bond, MG. Association of risk factors and body iron status to carotid atherosclerosis in middle-aged Eastern Finnish men. European Heart Journal 1994; 15: 1020–7.CrossRefGoogle ScholarPubMed
12Duthie, GG, Beattie, JAG, Arthur, JR, Franklin, M, Morrice, PC, James, WPT. Blood antioxidants and indices of lipid peroxidation in subjects with stable angina. Nutrition 1994; 10: 313–31.Google Scholar
13Rengström, J, Tonrvall, P, Kallner, A, Nilsson, J, Hamsten, A. Stored iron levels and myocardial infarction at a young age. Atherosclerosis 1994; 106: 123–5.Google Scholar
14Moore, M, Folsom, AR, Barnes, RW, Eckfeldt, JH. No association between serum ferritin and asymptomatic carotid atherosclerosis. The Atherosclerosis Risk in Communities (ARIC) Study. American Journal of Epidemiology 1995; 141: 719–23.CrossRefGoogle ScholarPubMed
15van der Schouw, YT, Verbeek, A, Ruijs, J. ROC curves for the initial assessment of new diagnostic tests. Family Practice 1992; 9: 506–11.CrossRefGoogle ScholarPubMed
16Eichner, JE, Qi, H, Moore, WE, Schechter, E. Iron measures in coronary angiography patients. Atherosclerosis 1998; 136: 241–5.CrossRefGoogle ScholarPubMed
17Wolff, B, Volzke, H, Ludemann, J, Robinson, D, Vogelgesang, D, Staudt, A, et al. Association between high serum ferritin levels and carotid atherosclerosis in the study of health in Pomerania (SHIP). Stroke 2004; 35: 453–7.CrossRefGoogle ScholarPubMed
18Kiechl, S, Aichner, F, Gerstenbrand, F, Egger, G, Mair, A, Rungger, G, et al. Body iron stores and the risk of carotid atherosclerosis: prospective results from the Bruneck study. Circulation 1997; 96: 3300–7.CrossRefGoogle ScholarPubMed
19Salonen, JT, Nyyssonen, K, Korpela, H, Tuomilehto, J, Seppanen, R, Salonen, R. High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men. Circulation 1992; 86: 803–11.CrossRefGoogle ScholarPubMed
20Salonen, JT, Nyyssonen, K, Salonen, R. Body iron stores and the risk of coronary heart disease [letter]. New England Journal of Medicine 1994; 331: 1159.Google ScholarPubMed
21Stampfer, MJ, Grodstein, F, Rosenberg, I, Willett, WC, Hennekens, CH. A prospective study of plasma ferritin and risk of myocardial infarction in US physicians [abstract]. Circulation 1993; 87: 10.Google Scholar
22Manttari, M, Manninen, V, Huttunen, JK, Palosuo, T, Ehnholm, C, Heinonen, OP, et al. Serum ferritin and ceruloplasmin as coronary risk factors. European Heart Journal 1994; 15: 1599–603.CrossRefGoogle ScholarPubMed
23Magnusson, MK, Sigfusson, N, Sigvaldason, H, Johannesson, M, Magnusson, S, Thorgeirsson, G. Low iron-binding capacity as a risk factor for myocardial infarction. Circulation 1994; 89: 102–8.CrossRefGoogle ScholarPubMed
24Frey, GH, Krider, DW. Serum ferritin and myocardial infarct. West Virginia Medical Journal 1994; 90: 13–5.Google ScholarPubMed
25Baer, DM, Tekawa, IS, Hurley, LB. Iron stores are not associated with acute myocardial infarction. Circulation 1994; 89: 2915–8.CrossRefGoogle Scholar
26Sempos, CT, Looker, AC, Gillum, RF, Makuc, DM. Body iron stores and the risk of coronary heart disease. New England Journal of Medicine 1994; 330: 1119–24.CrossRefGoogle ScholarPubMed
27Liao, Y, Cooper, RS, McGee, DL. Iron status and coronary heart disease: negative findings from the NHANES I epidemiologic follow-up study. American Journal of Epidemiology 1994; 139: 704–12.CrossRefGoogle ScholarPubMed
28Reunanen, A, Takkunen, H, Knekt, P, Seppanen, R, Aromaa, A. Body iron stores, dietary iron intake and coronary heart disease mortality. Journal of Internal Medicine 1995; 238: 223–30.CrossRefGoogle ScholarPubMed
29van Asperen, IA, Feskens, EJM, Bowles, CH, Kromhout, D. Body iron stores and mortality due to cancer and ischaemic heart disease: a 17-year follow-up study of elderly men and women. International Journal of Epidemiology 1995; 24: 665–70.CrossRefGoogle ScholarPubMed
30Morrison, HI, Semenciw, RM, Mao, Y, Wigle, DT. Serum iron and risk of fatal acute myocardial infarction. Epidemiology 1994; 5: 243–6.CrossRefGoogle ScholarPubMed
31Ascherio, A, Willett, WC, Rimm, EB, Giovannucci, EL, Stampfer, MJ. Dietary iron intake and risk of coronary disease among men. Circulation 1994; 89: 969–74.CrossRefGoogle ScholarPubMed
32Knuiman, MW, Divitini, ML, Olynyk, JK, Cullen, DJ, Bartholomew, HC. Serum ferritin and cardiovascular disease: a 17-year follow-up study in Busselton, Western Australia. American Journal of Epidemiology 2003; 158: 144–9.CrossRefGoogle ScholarPubMed
33Galan, P, Yoon, H-C, Preziosi, P, Viteri, F, Valeix, P, Fieux, B, et al. Determining factors in the iron status of adult women in the SU.VI.MAX study. European Journal of Clinical Nutrition 1998; 52: 383–8.CrossRefGoogle ScholarPubMed
34Hercberg, S, Preziosi, P, Briançon, S, Galan, P, Paul-Dauphin, A, Malvy, D, et al. A primary prevention trial of nutritional doses of antioxidant vitamins and minerals on cardiovascular diseases and cancers in general population: The SU.VI.MAX Study. Design, methods and participant characteristics. Controlled Clinical Trials 1998; 19: 336–51.CrossRefGoogle ScholarPubMed
35Hercberg, S, Galan, P, Preziosi, P, Bertrais, S, Mennen, L, Malvy, D, et al. The SUVI MAX study: a randomised, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Archives of Internal Medicine 2004; 164: 1–8.CrossRefGoogle Scholar
36World Health Organization (WHO). International Statistical Classification of Diseases and Related Health Problems, 10th version. Geneva: WHO, 1992.Google Scholar
37Sullivan, JL. Iron and the sex difference in heart disease risk. Lancet 1981; 1: 1293–4.CrossRefGoogle ScholarPubMed
38Danesh, J, Appleby, P. Coronary heart disease and iron status. Meta-analyses of prospective studies. Circulation 1999; 99: 852–4.CrossRefGoogle ScholarPubMed
39Ascherio, A, Rimm, EB, Giovannucci, E, Willett, WC, Stampfer, MJ. Blood donations and risk of coronary heart disease in men. Circulation 2001; 103: 52–7.CrossRefGoogle ScholarPubMed
40Meyers, DG, Strickland, D, Maloley, PA, Seburg, JK, Wilson, JE, McManus, BF. Possible association of a reduction in cardiovascular events with blood donation. Heart 1997; 78: 188–93.CrossRefGoogle ScholarPubMed
41Salonen, JT, Tuomainen, TP, Salonen, R, Lakka, TA, Nyyssonen, K. Donation of blood is associated with reduced risk of myocardial infarction. The Kuopio Ischaemic Heart Disease Risk Factor Study. American Journal of Epidemiology 1998; 148: 445–51.CrossRefGoogle ScholarPubMed
42Williams, MJA, Poulton, R, Williams, S. Relationship of serum ferritin with cardiovascular risk factors and inflammation in young men and women. Atherosclerosis 2002; 165: 179–84.CrossRefGoogle ScholarPubMed
43Oshaug, A, Bugge, KH, Bjonnes, CH, Borch-Iohnsen, B, Neslein, IL. Associations between serum ferritin and cardiovascular risk factors in healthy young men: a cross sectional study. European Journal of Clinical Nutrition 1995; 49: 430–8.Google ScholarPubMed
44Halle, M, Konig, D, Berg, A, Keul, J, Baumstark, MW. Relationship of serum ferritin concentrations with metabolic cardiovascular risk factors in men without evidence for coronary artery disease. Atherosclerosis 1997; 128: 235–40.CrossRefGoogle ScholarPubMed