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A review of the epidemiological evidence for the ‘antioxidant hypothesis’

Published online by Cambridge University Press:  02 January 2007

SA Stanner ,
J Hughes ,
CNM Kelly  and
J Buttriss
SA Stanner*
Affiliation:
British Nutrition Foundation, 52–54 High Holborn, London WC1V 6RQ, UK
J Hughes
Affiliation:
7 Holmesdale Park, Coopers Hill Road, Nuffield, Surrey, RH1 4NW, UK
CNM Kelly
Affiliation:
British Nutrition Foundation, 52–54 High Holborn, London WC1V 6RQ, UK
J Buttriss
Affiliation:
British Nutrition Foundation, 52–54 High Holborn, London WC1V 6RQ, UK
*
*Corresponding author: Email [email protected]
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Abstract

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Objective:

The British Nutrition Foundation was recently commissioned by the Food Standards Agency to conduct a review of the government's research programme on Antioxidants in Food. Part of this work involved an independent review of the scientific literature on the role of antioxidants in chronic disease prevention, which is presented in this paper.

Background:

There is consistent evidence that diets rich in fruit and vegetables and other plant foods are associated with moderately lower overall mortality rates and lower death rates from cardiovascular disease and some types of cancer. The ‘antioxidant hypothesis’ proposes that vitamin C, vitamin E, carotenoids and other antioxidant nutrients afford protection against chronic diseases by decreasing oxidative damage.

Results:

Although scientific rationale and observational studies have been convincing, randomised primary and secondary intervention trials have failed to show any consistent benefit from the use of antioxidant supplements on cardiovascular disease or cancer risk, with some trials even suggesting possible harm in certain subgroups. These trials have usually involved the administration of single antioxidant nutrients given at relatively high doses. The results of trials investigating the effect of a balanced combination of antioxidants at levels achievable by diet are awaited.

Conclusion:

The suggestion that antioxidant supplements can prevent chronic diseases has not been proved or consistently supported by the findings of published intervention trials. Further evidence regarding the efficacy, safety and appropriate dosage of antioxidants in relation to chronic disease is needed. The most prudent public health advice remains to increase the consumption of plant foods, as such dietary patterns are associated with reduced risk of chronic disease.

Keywords

AntioxidantFruit and vegetablesOxidative damageCancerCardiovascular disease
Type
Research Article
Information
Public Health Nutrition , Volume 7 , Issue 3 , May 2004 , pp. 407 - 422
Copyright
Copyright © CAB International 2004

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