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Iodine deficiency disorders in Europe

Published online by Cambridge University Press:  27 September 2007

Paolo Vitti ,
Teresa Rago ,
Fabrizio Aghini-Lombardi  and
Aldo Pinchera
Paolo Vitti*
Affiliation:
Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Università di Pisa
Teresa Rago
Affiliation:
Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Università di Pisa
Fabrizio Aghini-Lombardi
Affiliation:
Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Università di Pisa
Aldo Pinchera
Affiliation:
Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Università di Pisa
*
*Corresponding author: Email [email protected]
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Abstract

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Iodine deficiency disorders (IDD) are related to the degree of iodine deficiency. In european countries, characterized by mild to moderate iodine deficiency, neurological deficits or minor neuropsychological impairments have been described. Urinary iodine excretion (UIE) ranged from 30 to 170 mcg/L, 141 millions of people were at risk of IDD, 97 millions were affected by goiter and 0.9 millions had an impaired mental development.

Iodine prophylaxis is devoid of adverse reactions with the exception of sporadic cases of transitory hyperthyroidism, associated to the severity of iodine deficiency before the prophylaxis. The International Council for Control of IDD recommends an universal iodine prophylaxis, instituted gradually in severe iodine deficient countries. The total cost of universal iodine prophylaxis is very cheap compared to the social cost of goiter and cretinism.

In conclusion, most european countries are still characterized by mild to moderate iodine deficiency. Iodine prophylaxis programs are already operating, its cost is irrelevant with respect to the undebatable beneficial impact on the health. Adverse effects are not observed except in severe iodine deficient areas where iodine intake was abruptly increased.

Keywords

Iodine deficiencyEndemic cretinismGoiterIodine prophylaxisIodine intake
Type
Research Article
Information
Public Health Nutrition , Volume 4 , Issue 2b , April 2001 , pp. 529 - 535
Copyright
Copyright © CABI Publishing 2001

References

1Hetzel, BS. Iodine Deficiency Disorder (IDD) and their eradication. Lancet 1983; ii: 1126–9.CrossRefGoogle Scholar
2 Indicators for assessing Iodine Deficiency Disorder and their control through salt iodization. WHO/NUT/94.6.Google Scholar
3Dunn, JT, Pretell, EA, Daza, CH, Viteri, FE. Towards the eradication of endemic goiter, cretinism and iodine deficiency. Pan American Health Organization, World Health Organization, Scientific Publication. 1986: n. 502, 215–370.Google Scholar
4Delange, F.The disorders induced by iodine deficiency. Thyroid. 1994; 4: 107–28.CrossRefGoogle ScholarPubMed
5Gutekunst, R, Scriba, PC. Goiter and iodine deficiency in Europe. The European Thyroid Association report as updated in 1988. J. Endocrinol. Invest. 1989; 12: 209–20.CrossRefGoogle ScholarPubMed
6Contempre, B, Denef, JF, Dumont, JE, Many, MC. Selenium deficiency aggravates the necrotizing effect of a high iodine dose in iodine deficient rats. Endocrinology 1993; 132: 1866–8.CrossRefGoogle ScholarPubMed
7Aghini Lombardi, F, Pinchera, A, et al. Mild iodine deficiency during fetal/neonatal life and neuropsychological impairment in Tuscany. J. Endocrinol. Invest. 1995; 18: 57–62.CrossRefGoogle ScholarPubMed
8Chiovato, L, Aghini-Lombardi, F, Vitti, P, et al. The impact of iodine deficiency on neurological and cognitive development. The European experience. In: Stanbury, JB, ed. The Damaged Brain of Iodine Deficiency. New York: Cognizant Communication Co, 1994; Ch. 31: 293–8.Google Scholar
9Fenzi, GF, et al. Neuropsicological assessment in school-children from an area of moderate iodine deficiency. J. Endocrinol. Invest. 1990; 13: 427–43.CrossRefGoogle Scholar
10Vermiglio, F, Sidoti, M, Finocchiaro, MD, et al. Defective neuromotor and cognitive ability in iodine deficient school children of an endemic goiter region in Sicily. J. Clin. Endocrinol. Metab. 1990; 70: 379–84.CrossRefGoogle Scholar
11Bleichrodt, N, Escobar del Rey, F, Morreale de Escobar, G, Garcia, I, Rubio, C. Iodine deficiency: implications for mental and psychomotor development in children. In: DeLong, G, Robbins, J, Condliffe, PG, eds. Iodine and the Brain. New York: Plenum, 1989: 269–71.CrossRefGoogle Scholar
12Delange, F, Dunn, JT, Glinoer, D. Iodine deficiency in Europe: a continuing concern. eds. New York: Plenum Press, 1993: vol 241.CrossRefGoogle Scholar
13World Health Organization, United Nations Children's Found and International Council for Control of Iodine Deficiency Disorders; Elimination of iodine deficiency disorder (IDD) in Central and Eastern Europe, the Commonwealth of Independent States and the Baltic States. Proceedings of a conference held in MunichGermany3–6 September 1997. WHO/EURO/NUT/98.1.Google Scholar
14Aghini-Lombardi, F, Antonangeli, L, Vitti, P, Pinchera, A. Status of iodine nutrition in Italy. In: Delange, F, Dunn, JT, Glinoer, D, eds. Iodine deficiency in Europe. A continuing concern. New York: Plenum Press, 1993: 403–8.CrossRefGoogle Scholar
15Aghini-Lombardi, F, Antonangeli, L, Martino, E, et al. The spectrum of thyroid disorders in an iodine deficient community: the Pescopagano survey. J. Clin. Endocrinol. Metab. 1999; 84: 561–6.Google Scholar
16Lamberg, A.Endemic goiter in Finland and changes during 30years of iodine prophylaxis. Endocrinol. Exper. 1986; 20–35.Google Scholar
17Lauberg, P, Pederson, KM, Vestergaard, H, Siggurdsson, G.High incidence of multinodular toxic goitre in elderly population in a low iodine intake area vs high incidence of Graves' disease in the young in a high iodine intake area: comparative surveys of thyrotoxicosis epidemiology in East-Jutland Denmark and Iceland. J. Intern. Med. 1991; 229: 415–20.CrossRefGoogle Scholar
18Delange, F, Benker, G, Caron, PH, Eber, O, Peter, F, Podoba, J, Simescu, M, Szybinsky, Z, Vertongen, F, Vitti, P, Wiersinga, W, Zamrazil, V.Thyroid volume and urinary iodine in European schoolchildren: standardization of values for assessment of iodine deficiency. Eur. J. Endocrinol. 1997; 136: 180–7.CrossRefGoogle ScholarPubMed
19Aghini Lombardi, F, Pinchera, A, et al. Iodized salt prophylaxis of endemic goiter: an experience in Toscana (Italy). Acta. Endocrinol. 1993; 129: 497–500.Google ScholarPubMed
20Cao, XY, Jiang, XM, Dou, ZH, et al. Timing of vulnerability of the brain to iodine deficiency in endemic cretinism. N. Engl. J. Med. 1994; 331(26): 1739–44.CrossRefGoogle ScholarPubMed
21Adams, DD, Kennedy, TH, et al. Hyperthyroidism in Tasmania following iodide supplementation: measurements of thyroid stimulating antibodies and thyrotropin. J. Clin. Endocrinol. Metab. 1974; 41(2): 221–8.CrossRefGoogle Scholar
22Clugston, G, Beaury, M, Delange, F.Iodine-induced thyrotoxicosis. Lancet 1996; 347: 1051.CrossRefGoogle ScholarPubMed
23Todd, CH, Allain, T, et al. Increase in thyrotoxicosis associated with iodine supplements in Zimbabwe. Lancet 1995; 346: 1563–4CrossRefGoogle ScholarPubMed
24Bourdoux, P, Ermans, AM, et al. Iodine-induced thyrotoxicosis in Kivu, Zaire. Lancet 1996; 347: 552–3.CrossRefGoogle ScholarPubMed
25Baltisberger, BL, Minder, CE, Burgi, H.Decreased of incidence of toxic nodular goitre in a region of Switzerland after full correction of mild iodine deficiency. European Journal of Endocrinology 1995; 132: 546–9.CrossRefGoogle Scholar
26WHO-ICCIDD-UNICEF. Multicentre study to assess the impact of salt iodization level on iodine status. 1997.Google Scholar
27Delange, F, De Benoist, B, Alnwick, D.Risks of iodine induced hyperthyroidism after correction of iodine deficiency by iodized salt. Thyroid 1999; 9: 545–56.CrossRefGoogle ScholarPubMed
28Mannar, V, Dunn, JT. Salt Iodization for the elimination of iodine deficiency. ICCIDD UNICEF, World Health Organisation. Publication. 1995; 90: 70–85.Google Scholar