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The influence of dietary intake on the insulin-like growth factor (IGF) system across three ethnic groups: a population-based study

Published online by Cambridge University Press:  02 January 2007

AH Heald ,
JE Cade ,
JK Cruickshank ,
S Anderson ,
A White  and
JM Gibson
AH Heald*
Affiliation:
Endocrine Sciences Research Group, Faculty of Medicine and School of Biological Sciences, University of Manchester, Manchester, UK Department of Diabetes and Endocrinology, University of Manchester, Salford Royal Hospitals University Trust, Hope Hospital, Stott Lane, Salford, Greater Manchester M6 8HD, UK
JE Cade
Affiliation:
Clinical Epidemiology Unit, Department of Medicine, University of Manchester, Manchester, UK
JK Cruickshank
Affiliation:
Clinical Epidemiology Unit, Department of Medicine, University of Manchester, Manchester, UK
S Anderson
Affiliation:
Clinical Epidemiology Unit, Department of Medicine, University of Manchester, Manchester, UK
A White
Affiliation:
Endocrine Sciences Research Group, Faculty of Medicine and School of Biological Sciences, University of Manchester, Manchester, UK
JM Gibson
Affiliation:
Endocrine Sciences Research Group, Faculty of Medicine and School of Biological Sciences, University of Manchester, Manchester, UK
*
*Corresponding author: Email [email protected]
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Abstract

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Objective:

The insulin-like growth factor (IGF) system has been implicated in the aetiopathogenesis of cancer, cardiovascular disease and diabetes. Since dietary factors and ethnicity are considered contributory to the development of these diseases, we examined the IGF system in relation to nutritional intake by ethnic group.

Design, subjects and setting:

Dietary intake in 257 subjects of White European, African-Caribbean and Pakistani ethnic origin living in Manchester, UK was assessed using ethnic-group-specific food-frequency questionnaires to assess habitual nutrient intake over the previous 12 months. Fasting IGF-I, IGF-II and IGF-binding protein-1 (IGFBP-1) concentrations were determined and their relationship to specific dietary constituents was analysed.

Results:

Analysis by quintiles of nutrient intake showed a significant increase in circulating IGF-I concentration with increasing dietary fat intake (F for trend = 3.9, P < 0.01), saturated fat intake (F = 3.3, P = 0.01) and for protein intake (F = 4.2, P < 0.01). There was also a significant increase in IGF-II by quintiles of dietary protein intake (F = 2.7, P < 0.05). There was a trend for increasing IGF-I with increasing energy intake. The relationships between circulating concentration of IGFBP-1, an acute regulator of IGF action, and fat/protein intake were opposite to those for IGF-I and IGF-II. Multiple linear regression modelling showed that people of Pakistani origin and older subjects had lower levels of IGF-I (Pakistani origin vs. others, P < 0.001) (age, P < 0.001 for both). There was an independent inverse relationship between IGF-I and dietary carbohydrate intake (P = 0.036).

Conclusions:

This study provides evidence for a dietary contribution to regulation of the IGF system, although the effects of ethnicity on circulating IGF levels remain dominant. We propose that the IGF system's influences on cancer risk in specific ethnic groups are potentially modifiable by dietary intervention.

Keywords

DietInsulin-like growth factorsEthnicityIntervention
Type
Research Article
Information
Public Health Nutrition , Volume 6 , Issue 2 , April 2003 , pp. 175 - 180
Copyright
Copyright © CABI Publishing 2003

References

1Department of Health. Saving Lives: Our Healthier Nation. London: The Stationery Office, 1999.Google Scholar
2Davey Smith, G, Gunnell, D, Holly, J. Cancer and insulin-like growth factor-I. Br. Med. J. 2000; 321: 847–8.CrossRefGoogle Scholar
3Jones, JI, Clemmons, DR. Insulin-like growth factors and their binding proteins: biological actions. Endocr. Rev. 1995; 16: 3–34.Google ScholarPubMed
4Hankinson, SE, Willett, WC, Colditz, GA, Hunter, DJ, Michaud, DS, Deroo, B, et al. . Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet 1998; 351: 1393–6.CrossRefGoogle ScholarPubMed
5Chan, JM, Stampfer, MJ, Giovannucci, E, Gann, PH, Ma, J, Wilkinson, P, et al. . Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science 1998; 279: 563–6.CrossRefGoogle ScholarPubMed
6Ma, J, Pollak, MN, Giovannucci, E, Chan, JM, Tao, Y, Hennekens, CH. Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. J. Natl. Cancer Inst. 1999; 91: 620–5.CrossRefGoogle ScholarPubMed
7Spallarossa, P, Brunelli, C, Minuto, F, Caruso, D, Battistini, M, Caponnetto, S, et al. . Insulin-growth factor-I and angiographically documented coronary heart disease. Am. J. Cardiol. 1996; 77: 200–2.CrossRefGoogle Scholar
8Toretsky, JA, Helman, LJ. Involvement of IGF-II in human cancer. J. Endocrinol. 1996; 149: 367–72.CrossRefGoogle ScholarPubMed
9Yu, H, Rohan, T. Role of the insulin-like growth factor family in cancer development and progression. J. Natl. Cancer Inst. 2000; 92: 1472–89.CrossRefGoogle ScholarPubMed
10Sharma, S, Cade, J, Jackson, M, Mbanya, JC, Chungong, S, Forrester, T, et al. . Cross cultural assessment of diet in three population samples of African origin from Cameroon, Jamaica and Caribbean migrants to the UK: method development. Eur. J. Clin. Nutr. 1996; 50: 479–86.Google Scholar
11Crawley, H. Food Portion Sizes. London: Ministry of Agriculture, Fisheries and Food/Her Majesty's Stationery Office, 1988.Google Scholar
12Heald, AH, Cruickshank, JK, Riste, LK, Cade, JE, Anderson, S, Greenhalgh, A, et al. Close relationship of fasting insulin-like growth factor binding protein-1 (IGFBP-1) with glucose tolerance and cardiovascular risk in 2 populations. Diabetologia 2001; 44: 333–9.CrossRefGoogle Scholar
13Cruickshank, JK, Heald, AH, Anderson, S, Cade, J, Sampayo, J, Riste, LK, et al. Epidemiology of the insulin-like growth factor system in three ethnic groups. Am. J. Epidemiol. 2001; 154: 504–13.CrossRefGoogle ScholarPubMed
14Asp, NG. Carbohydrates – terminology update. Carbohydrates 2000; 11: 1–3.Google Scholar
15Kaklamani, VG, Linos, A, Kaklamani, E, Markaki, I, Koumantaki, Y, Mantzaros, CS. Dietary fat and carbohydrates are independently associated with circulating insulin-like growth factor-I and insulin-like growth factor binding protein-3 concentrations in healthy adults. J. Clin. Oncol. 1999; 17: 3291–8.CrossRefGoogle ScholarPubMed
16Devine, A, Rosen, C, Mohan, S, Baylink, D, Prince, RL. Effects of zinc and other nutritional factors on insulin-like growth factor-I and insulin-like growth factor binding proteins in healthy post-menopausal women. Am. J. Clin. Nutr. 1998; 68: 200–6.CrossRefGoogle Scholar
17Allen, NE, Appleby, PN, Davey, GK, Key, TJ. Hormones and diet: low insulin-like growth factor-I but normal biochemical androgens in vegan men. Br. J. Cancer 2000; 80: 95–7.CrossRefGoogle Scholar
18Thissen, JP, Ketelslegers, JM, Underwood, LE. Nutritional of the insulin-like growth factors. Endocr. Rev. 1994; 15: 80–101.Google ScholarPubMed
19Lee, PD, Giudice, LC, Conover, CA, Powell, DR. Insulin-like growth factor binding protein-1: recent findings and new directions. Proc. Soc. Exp. Biol. Med. 1997; 216: 319–57.CrossRefGoogle ScholarPubMed
20Clemmons, DR, Klibanski, A, Underwood, LE, McArthur, JW, Ridgway, EC, Beitins, IZ, et al. Reduction of plasma immunoreactive somatomedin C during fasting in humans. J. Clin. Endocrinol. Metab. 1981; 53: 1247–50.CrossRefGoogle ScholarPubMed
21Cohen, LA, Choi, KW, Wang, CX. Influence of dietary fat, calorie restriction and voluntary exercise on N-nitrosomethylurea-induced tumourigenesis in rats. Cancer Res. 1988; 48: 4276–83.Google Scholar
22Hursting, SD, Perkins, SN, Phang, JM. Calorie restriction delays spontaneous tumourigenesis in p53-knockout transgenic mice. Proc. Natl. Acad. Sci. USA 1994; 91: 7036–40.CrossRefGoogle Scholar
23Mukherjee, P, Sotnikov, AV, Mangian, HJ, Zhou, JR, Visek, WJ, Clinton, SK. Energy intake and prostate tumour growth, angiogenesis and vascular endothelial growth factor expression. J. Natl. Cancer Inst. 1999; 91: 512–23.CrossRefGoogle ScholarPubMed
24Dunn, SE, Kari, FW, French, J, Leininger, JR, Travlos, J, Wilson, R, et al. Dietary restriction reduces insulin-like growth factor-I levels which modulates apoptosis, cell proliferation and tumour progression in p53-defidient mice. Cancer Res. 1997; 57: 4667–72.Google ScholarPubMed
25Lichtenstein, P, Holm, NV, Verkasalo, PK, Iliadou, A, Kaprio, J, Koskenvuo, M, et al. Environmental and heritable factors in the causation of cancer – analyses of cohorts of twins from Sweden, Denmark and Finland. N. Engl. J. Med. 2000; 343: 78–85.CrossRefGoogle ScholarPubMed