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Dietary questions as determinants of mortality: the OXCHECK experience

Published online by Cambridge University Press:  02 January 2007

David Whiteman ,
John Muir ,
Lesley Jones ,
Mike Murphy  and
Tim Key
David Whiteman*
Affiliation:
ICRF General Practice Research Group, Institute of Health Sciences, Old Road, Oxford, OX3 7LF, UK
John Muir
Affiliation:
ICRF General Practice Research Group, Institute of Health Sciences, Old Road, Oxford, OX3 7LF, UK
Lesley Jones
Affiliation:
ICRF General Practice Research Group, Institute of Health Sciences, Old Road, Oxford, OX3 7LF, UK
Mike Murphy
Affiliation:
ICRF General Practice Research Group, Institute of Health Sciences, Old Road, Oxford, OX3 7LF, UK
Tim Key
Affiliation:
ICRF Cancer Epidemiology Unit, Radcliffe Infirmary, Oxford, OX2 6HE, UK
*
*Corresponding author: Email [email protected]
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Abstract

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Objective:

To determine whether responses to simple dietary questions are associated with specific causes of death.

Design:

Self-reported frequency intakes of various classes of foods and data on confounding factors were collected at the baseline survey. Death notifications up to 31 December 1997 were ascertained from the Office for National Statistics. Relative risk (RR) of death and 95% confidence intervals (CI) associated with baseline dietary factors were calculated by Cox regression.

Setting:

Prospective follow-up study based on five UK general practices.

Subjects:

Data were used from 11 090 men and women aged 35–64 years (81% of the eligible patient population) who responded to a postal questionnaire in 1989.

Results:

After 9 years of follow-up, 598 deaths were recorded, 514 of these among the 10 522 subjects with no previous history of angina. All-cause mortality was positively associated with age, smoking and low social class, as expected. Among the dietary variables, all-cause mortality was significantly reduced in participants who reported relatively high consumption of vegetables, puddings, cakes, biscuits and sweets, fresh or frozen red meat (but not processed meat), among those who reported using polyunsaturated spreads and among moderate alcohol drinkers. These associations were broadly similar for deaths from ischaemic heart disease (IHD), cancer and all other causes combined, and were not greatly attenuated by adjusting for potential confounding factors including social class.

Conclusions:

Responses to simple questions about nutrition were associated with mortality. These findings must be interpreted with caution since residual confounding by dietary and lifestyle factors may underlie the associations.

Keywords

DietNutritionFollow-up studyRisk factors
Type
Research Article
Information
Public Health Nutrition , Volume 2 , Issue 4 , April 1999 , pp. 477 - 487
Copyright
Copyright © CABI Publishing 1999

References

1Klor, HU, Hauenschild, A, Holbach, I, Schnell-Kretschmer, H, Stroh, S. Nutrition and cardiovascular disease. Eur. J. Med. Res. 1997; 2: 243–57.Google Scholar
2Imperial Cancer Research Fund OXCHECK Study Group. Prevalence of risk factors for heart disease in OXCHECK trial: implications for screening in primary care. BMJ 1991; 302: 1057–60.Google Scholar
3Rose, G, Mccartney, P, Reid, DD. Self-administration of a questionnaire on chest pain and intermittent claudication. Br. J. Prev. Soc. Med. 1977; 31: 42–8.Google ScholarPubMed
4Coulter, A. Lifestyles and social class: implications for primary care. J. R. Coll. Gen. Pract. 1987; 37: 533–6.Google Scholar
5Office of Population Censuses and Surveys. Classification of Occupations. London: HMSO, 1980.Google Scholar
6 SAS Institute. SAS v6.12. Cary, NC, 1996.Google Scholar
7Gillman, M, Cupples, A, Gagnon, D, et al. Protective effect of fruits and vegetables. JAMA 1995; 273: 1113–17.CrossRefGoogle ScholarPubMed
8Ascherio, A, Willett, WC, Rimm, EB, Giovannucci, EL, Stampfer, MJ. Dietary iron intake and risk of coronary disease among men. Circulation 1994; 89: 969–74.CrossRefGoogle ScholarPubMed
9Snowdon, DA, Phillips, RL, Fraser, GE. Meat consumption and fatal ischemic heart disease. Prev. Med. 1984; 13: 490–500.Google Scholar
10Cox, BD, Whichelow, MJ. Frequent consumption of red meat is not risk factor for cancer. BMJ 1997; 315: 1018.Google Scholar
11Kromhout, D, Bloemberg, BPM. Methods in nutritional epidemiology. In: Marmot, M, Elliott, P, eds. Coronary Heart Disease Epidemiology: from Aetiology to Public Health. Oxford: Oxford University Press, 1992; 140–51.Google Scholar
12Sackett, DL. Bias in analytic research. J. Chron. Dis. 1979; 32: 51–63.CrossRefGoogle ScholarPubMed
13Wright, L, Harwood, D, Coulter, A. Health and Lifestyles in the Oxford Region. Oxford: Health Services Research Unit, 1992.Google Scholar