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Development of a short questionnaire to assess the dietary intake of heterocyclic aromatic amines

Published online by Cambridge University Press:  22 December 2006

Sabine Rohrmann  and
Nikolaus Becker
Sabine Rohrmann*
Affiliation:
Deutsches Krebsforschungszentrum, Division of Clinical Epidemiology, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany
Nikolaus Becker
Affiliation:
Deutsches Krebsforschungszentrum, Division of Clinical Epidemiology, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany
*
*Corresponding author: Email [email protected]
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Abstract

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Objective:

Development and validation of a short instrument to assess the dietary intake of heterocyclic aromatic amines (HCA).

Design:

At first, a longer instrument asking for the consumption of 11 meat and fish items and different preparation methods was developed. The degree of browning of these foods was assessed by means of photos. This questionnaire was sent to 500 participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) in Heidelberg, Germany, in June 1999. Using 385 completed questionnaires, a short questionnaire was developed covering just seven food items, which was sent to the participants again. Of these, 344 were returned with in four months. Total dietary intake of HCA as well as the intake of different HCA were calculated and compared between both versions.

Results:

Median dietary intake of total HCA was 103ng day−1as assessed with the short version; the intakes of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP),2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx) were 63, 34 and 2ng day−1, respectively. These results did not differ significantly from those obtained with the longer version. Spearman rank correlation coefficients between the long and the short version ranged from 0.46 to 0.6. In quartile cross-classification, 70–78% of the participants were assigned into the same or an adjacent quartile while categorisation into opposite quartiles was ≤3.5%.

Conclusion:

The short version of the HCA questionnaire demonstrates good validity compared with the longer version. The intake of HCA as assessed with the short questionnaire is comparable to that found in other studies using a short questionnaire.

Keywords

Heterocyclic aromatic aminesNutrition assessmentQuestionnaireIntakeEpidemiologyEPIC
Type
Research Article
Information
Public Health Nutrition , Volume 5 , Issue 5 , December 2002 , pp. 699 - 705
Copyright
Copyright © CABI Publishing 2002

References

1Sugimura, T. Overview of carcinogenic heterocyclic amines. Mut. Res. 1997; 376: 211–9.CrossRefGoogle ScholarPubMed
2Skog, K, Johansson, MAE, Jaägerstad, MJ. Carcinogenic heterocyclic amines in model systems and cooked foods: a review on formation, occurrence and intake. Food Chem. Toxicol. 1998; 36: 879–96.Google Scholar
3Layton, DW, Bogen, KT, Knize, MG, et al. Cancer risk of heterocyclic amines in cooked foods: an analysis and implications for research. Carcinogenesis 1995; 16: 39–52.CrossRefGoogle ScholarPubMed
4Gross, GA, Grüter, A. Quantification of mutagenic/carcinogenic heterocyclic aromatic amines in food products. J. Chromatogr. 1992; 592: 271–8.Google Scholar
5Adamson, RH, Thorgeirsson, UP, Snyderwine, EG, et al. Carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in nonhuman primates: induction of tumors in three macaques. Jpn. J. Cancer Res. 1990; 81: 10–4.CrossRefGoogle Scholar
6Shirai, T, Tamano, S, Sano, M, et al. Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) inrats: dose–respose studies. Princess Takamatsu Symposia 1995; 23: 232–9.Google Scholar
7Sinha, R, Kulldorff, M, Chow, W-H, et al. Dietary intake of heterocyclic amines, meat-derived mutagenic activity, and risk of colorectal adenomas. Cancer Epidemiol. Biomark. Prev. 2001; 10: 559–62.Google ScholarPubMed
8Sinha, R, Kulldorff, M, Swanson, CA, et al. Dietary heterocyclic amines and the risk of lung cancer among Missouri women. Cancer Res. 2000; 60: 3753–7.Google ScholarPubMed
9Sinha, R, Gustafson, DR, Kulldorf, M, et al. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, a carcinogen in high-temperature-cooked meat, and breast cancer risk. J. Natl. Cancer Inst. 2000; 92: 1352–4.CrossRefGoogle ScholarPubMed
10De Stefani, E, Boffetta, P, Mendilaharsu, M, et al. Dietary nitrosamines, heterocyclic amines, and risk of gastric cancer: a case–control study in Uruguay. Nutr. Cancer 1998; 30: 158–62.CrossRefGoogle ScholarPubMed
11De Stefani, E, Ronco, A, Mendilaharsu, M, et al. Case–control study on the role of heterocyclic amines in the atiology of upper aerodigestive cancers in Uruguay. Nutr. Cancer 1998; 32: 43–8.CrossRefGoogle Scholar
12De Stefani, E, Ronco, A, Mendilaharsu, M, et al. Meat intake, heterocyclic amines, and risk of breast cancer: a case–control study in Uruguay. Cancer Epidemiol. Biomark. Prev. 1997; 6: 573–81.Google Scholar
13De Stefani, E, Doneo-Pellegrini, H, Mendilaharsu, M, et al. Meat intake, heterocyclic amines and risk of colorectal cancer: a case–control study in Uruguay. Int. J. Oncol. 1997; 10: 573–80.Google Scholar
14Norrish, AE, Ferguson, LR, Knize, MG, et al. Heterocyclic amine content of cooked meat and risk of prostate cancer. J. Natl. Cancer Inst. 1999; 91: 2038–44.CrossRefGoogle ScholarPubMed
15Delfino, RJ, Sinha, R, Smith, C, et al. Breast cancer, heterocyclic amines from meat and N-acetyltransferase 2 genotype. Carcinogenesis 2000; 21: 607–15.Google Scholar
16Augustsson, K, Skog, K, Jägerstad, M, et al. Dietary heterocyclic amines and cancer of the colon, rectum, bladder, and kidney: a population-based study. Lancet 1999; 353: 703–7.CrossRefGoogle ScholarPubMed
17Lyon, JL, Mahoney, AW. Fried foods and the risk of colon cancer. Am. J. Epidemiol. 1988; 128: 1000–6.Google Scholar
18Voskuil, DW, Augustsson, K, Dickman, PW, et al. Assessing the human intake of heterocyclic aromatic amines: limited loss of information using reduced sets of questions. Cancer Epidemiol. Biomark. Prev. 1999; 8: 809–14.Google Scholar
19Riboli, E, Kaaks, R. The EPIC project: rationale and study design. Int. J.Epidemiol. 1997; 26(1):S6–14.CrossRefGoogle ScholarPubMed
20Boeing, H, Wahrendorf, J, Becker, N. EPIC–Germany – a source for studies into diet and risk of chronic diseases. Ann. Nutr. Metab. 1999; 43: 195–204.CrossRefGoogle ScholarPubMed
21Boeing, H, Korfmann, A, Bergmann, MM. Recruitment procedures of EPIC–Germany. Ann. Nutr. Metab. 1999; 43: 205–15.CrossRefGoogle ScholarPubMed
22Bergmann, M, Bussas, U, Boeing, H. Follow-up procedures in EPIC–Germany – data quality aspects. Ann. Nutr. Metab. 1999; 43: 225–34.CrossRefGoogle ScholarPubMed
23Brandstetter, BR, Korfmann, A, Bergmann, MM. Dietary habits in the German EPIC cohorts: food group intake estimated with food frequency questionnaire. Ann. Nutr. Metab. 1999; 43: 246–57.Google Scholar
24Zhang, X-M, Wakabayashi, K, Liu, Z-C, et al. Mutagenic and carcinogenic heterocyclic amines in Chinese cooked foods. Mut. Res. 1988; 201: 181–8.Google Scholar
25Taylor, SL, Berg, CM, Shoptaugh, NH, et al. Lack of mutagens in deep-fat fried foods obtained at the retail level. Food Chem. Toxicol. 1982; 20: 209–12.CrossRefGoogle ScholarPubMed
26Nilsson, L, Övervik, E, Fredholm, L, et al. Influence of frying fat on mutagenic activity in lean pork meat. Mut. Res. 1986; 171: 115–21.Google Scholar
27Bohlscheid-Thomas, S, Hoting, I, Boeing, H, et al. Reproducibility and relative validity of energy and macronutrient intake of a food frequency questionnaire developed for the German part of the EPIC project. Int. J. Epidemiol. 1997; 26(Suppl 1): S71–81.CrossRefGoogle ScholarPubMed
28Augustsson, K, Skog, K, Jägerstad, M, et al. Assessment of the human exposure of heterocyclic amines. Carcinogenesis 1997; 18: 1931–5.CrossRefGoogle ScholarPubMed
29Abdulkarim, BG, Smith, JS. Heterocyclic amines in fresh and processed meat products. J. Agric. Food Chem. 1998; 46: 4680–7.Google Scholar
30Sinha, R, Knize, MG, Salmon, CP, et al. Heterocyclic amine content of pork products cooked by different methods and by varying degrees of doneness. Food Chem. Toxicol. 1998; 36: 289–97.Google Scholar
31Sinha, R, Rothman, N, Brown, ED, et al. High concentrations of the carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine [PhIP] occur in chicken but depending on the cooking temperature. Cancer Res. 1995; 55: 4516–9.Google Scholar
32Skog, K, Augustsson, K, Steineck, G, et al. Polar and non-polar heterocyclic amines in cooked fish and meat products and their corresponding pan residues. Food Chem. Toxicol. 1997; 35: 555–65.Google Scholar
33Skog, K, Steineck, G, Augustsson, K, et al. Effect of cooking temperature on the formation of heterocyclic amines in fried meat products and pan residues. Carcinogenesis 1995; 16: 861–7.CrossRefGoogle ScholarPubMed
34Mark, SD, Thomas, DG, Decarli, A. Measurement of the exposure to nutrients: an approach to the selection of informative foods. Am. J. Epidemiol. 1996; 143: 514–21.Google Scholar
35Thomas, DG, Mark, SD. Max_r: an optimal method for the selection of subsets of foods for the measurement of specific nutrient exposures. Comp. Meth. Prog. Biomed. 1997; 54: 151–6.CrossRefGoogle ScholarPubMed
36National Research Council. Diet and Health: Implications for Reducing Chronic Disease Risk. Washington, DC: National Academy Press, 1989.Google Scholar
37Goldberg, GR, Black, AE, Jebb, SA, et al. Critical evaluation of energy intake data using fundamental principles of energy physiology: 1. Derivation of cut-off limits to identify under-recording. Eur. J. Clin. Nutr. 1991; 45: 569–81.Google Scholar
38Garrow, JS. Validation of methods for estimating habitual diets: proposed guidelines. Eur. J. Clin. Nutr. 1995; 49: 231–2.Google ScholarPubMed
39Byrne, C, Sinha, R, Platz, EA, et al. Predictors of dietary heterocyclic amines in three prospective cohorts. Cancer Epidemiol. Biomark. Prev. 1998; 7: 523–9.Google ScholarPubMed
40Gordis, L. Epidemiology. Philadelphia, PA: WB Saunders Company, 1996.Google Scholar
41Willett, WC. Nutritional Epidemiology, 2nd ed. New York: Oxford University Press, 1998.CrossRefGoogle Scholar
42Block, G, Hartman, AM. Issues in reproducibility and validity of dietary studies. Am. J. Clin. Nutr. 1989; 50: 1133–8.Google Scholar
43Dobson, AJ, Blijlevens, R, Alexander, HM, et al. Short fat questionnaire: a self-administered measure of fat-intake behaviour. Aust. J. Public Health 1993; 17: 144–9.Google Scholar
44Bingham, SA, Gill, C, Welch, A, et al. Comparison of dietary assessment methods in nutritional epidemiology: weighed records v. 24th recalls, food-frequency questionnaires and estimated-diet records. Br. J. Nutr. 1994; 72: 619–43.Google Scholar
45Ji, H, Yu, MC, Stillwell, WG, et al. Urinary excretion of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in white, black, and Asian men in Los Angeles County. Cancer Epidemiol. Biomark. Prev. 1994; 3: 407–11.Google Scholar
46Kidd, LCR, Stillwell, WG, Yu, MC, et al. Urinary excretion of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in white, African-American, and Asian-American men in Los Angeles County. Cancer Epidemiol. Biomark. Prev. 1999; 8: 439–45.Google ScholarPubMed
47Mauthe, RJ, Dingley, KH, Leveson, SH, et al. Comparison of DNA-adduct and tissue-available dose levels of MeIQx in human and rodent colon following administration of a very low dose. Int. J. Cancer 1999; 80: 539–45.3.0.CO;2-C>CrossRefGoogle ScholarPubMed
48Wakabayashi, K, Totsuka, Y, Fukotome, K, et al. Human exposure to mutagenic/carcinogenic heterocyclic amines and co-mutagenic β-carbolines. Mut. Res. 1997; 376: 253–9.CrossRefGoogle Scholar