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Volume 39 - May 2009

Contents

Page 12 of 14

Book Review

Original Articles

  • Duration discrimination in the range of milliseconds and seconds in children with ADHD and their unaffected siblings

  • S. Himpel, T. Banaschewski, A. Grüttner, A. Becker, A. Heise, H. Uebel, B. Albrecht, A. Rothenberger, T. Rammsayer
  • Published online by Cambridge University Press:
    06 March 2009, pp. 1745-1751
  • Background

    Detecting genetic factors involved in attention deficit hyperactivity disorder (ADHD) is complicated because of their small effect sizes and complex interactions. The endophenotype approach eases this by coming closer to the relevant genes. Different aspects of temporal information processing are known to be affected in ADHD. Thus, some of these aspects could represent candidate endophenotypes for ADHD.

    Method

    Fifty-four sib-pairs with at least one child with ADHD and 40 control children aged 6–18 years were recruited and asked to perform two duration discrimination tasks, one with a base duration of 50 ms on automatic timing and one with a base duration of 1000 ms on cognitively controlled timing.

    Results

    Whereas children with ADHD, but not their unaffected siblings, were impaired in discrimination of longer intervals, both groups were impaired in discriminating brief intervals. Furthermore, a significant within-family correlation was found for discrimination of brief intervals. Task performances of subjects of the control group correlated with individual levels of hyperactivity/impulsivity for discrimination of brief intervals, but not of longer intervals.

    Conclusions

    Cognitively controlled and also automatic processes of temporal information processing are impaired in children with ADHD. Discrimination of longer intervals appears as a typical ‘disease marker’ whereas discrimination of brief intervals shows up as a ‘vulnerability marker’. Discrimination of brief intervals was found to be familial and linked to levels of hyperactivity/impulsivity. Taken together, discrimination of brief intervals represents a candidate endophenotype of ADHD.

Book Review

Front Cover (OFC, IFC) and matter

  • PSM volume 39 issue 2 Cover and Front matter

  • Published online by Cambridge University Press:
    15 January 2009, pp. f1-f2
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Book Review

Front Cover (OFC, IFC) and matter

  • PSM volume 39 issue 12 Cover and Front matter

  • Published online by Cambridge University Press:
    11 November 2009, pp. f1-f2
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Research Letter

  • Research Letter: Electrosensitives and perception of magnetic pulses

  • U. FRICK, P. EICHHAMMER, B. LANGGUTH, G. HAJAK, M. LANDGREBE
  • Published online by Cambridge University Press:
    09 April 2009, pp. 1050-1052
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Book Review

Books Received

Back Cover (IBC, OBC) and matter

  • PSM volume 39 issue 2 Cover and Back matter

  • Published online by Cambridge University Press:
    15 January 2009, pp. b1-b2
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Front Cover (OFC, IFC) and matter

  • PSM volume 39 issue 9 Cover and Front matter

  • Published online by Cambridge University Press:
    05 August 2009, pp. f1-f2
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Correspondence

Book Review

Correspondence

  • Letter to the Editor

  • MATTHEW LARGE, GLEN SMITH, OLAV NIELSSEN
  • Published online by Cambridge University Press:
    12 February 2009, pp. 699-700
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Book Review

Correspondence

Page 12 of 14