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Volume 49 - January 2019

Contents

Page 17 of 17

Front Cover (OFC, IFC) and matter

  • PSM volume 49 issue 16 Cover and Front matter

  • Published online by Cambridge University Press:
    25 November 2019, pp. f1-f2
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Correspondence

  • The limitations of equivalence and non-inferiority trials

  • Winfried Rief, Stefan G. Hofmann
  • Published online by Cambridge University Press:
    08 October 2018, pp. 349-350
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  • Equivalence and non-inferiority trials are becoming more and more popular. Typically, they compare the effects of a treatment of interest with the current gold-standard treatment as the comparator. However, for this approach, the definition of equivalence or non-inferiority margins (NIM) is crucial, and no clear rules for their definition exist. We criticized the practice of these trials of being over-inflationary in favor of (erroneous) equivalence, and we outlined our critique with some study examples comparing psychodynamic treatments with current first-line treatments for mental disorders. Here we answer to a commentary of Leichsenring et al. to our paper. Although focusing on our commentary, these authors are less arguing against our conclusions, but they address issues of study conduct, and lack of appreciation of our examples. However, the crucial question is: What is the risk of erroneous equivalence conclusions that we want to accept as responsible clinicians and scientists? We conclude that the scientific community has to define better and clearer criteria for NIMs. We do not believe that it is ethically justifiable to recommend a treatment that is 10 or 20% less effective than the current gold standard interventions.

Front Cover (OFC, IFC) and matter

  • PSM volume 49 issue 10 Cover and Front matter

  • Published online by Cambridge University Press:
    28 June 2019, pp. f1-f2
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  • PSM volume 49 issue 15 Cover and Front matter

  • Published online by Cambridge University Press:
    22 October 2019, pp. f1-f2
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  • PSM volume 49 issue 6 Cover and Front matter

  • Published online by Cambridge University Press:
    20 March 2019, pp. f1-f2
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  • PSM volume 49 issue 4 Cover and Front matter

  • Published online by Cambridge University Press:
    12 February 2019, pp. f1-f2
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Back Cover (IBC, OBC) and matter

  • PSM volume 49 issue 5 Cover and Back matter

  • Published online by Cambridge University Press:
    19 March 2019, pp. b1-b2
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  • PSM volume 49 issue 3 Cover and Back matter

  • Published online by Cambridge University Press:
    11 January 2019, pp. b1-b2
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  • PSM volume 49 issue 15 Cover and Back matter

  • Published online by Cambridge University Press:
    22 October 2019, pp. b1-b2
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  • PSM volume 49 issue 10 Cover and Back matter

  • Published online by Cambridge University Press:
    28 June 2019, pp. b1-b2
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  • PSM volume 49 issue 16 Cover and Back matter

  • Published online by Cambridge University Press:
    25 November 2019, pp. b1-b2
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Corrigendum

Front Cover (OFC, IFC) and matter

  • PSM volume 49 issue 1 Cover and Front matter

  • Published online by Cambridge University Press:
    18 December 2018, pp. f1-f2
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Back Cover (IBC, OBC) and matter

  • PSM volume 49 issue 6 Cover and Back matter

  • Published online by Cambridge University Press:
    20 March 2019, pp. b1-b2
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  • PSM volume 49 issue 4 Cover and Back matter

  • Published online by Cambridge University Press:
    12 February 2019, pp. b1-b2
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  • PSM volume 49 issue 1 Cover and Back matter

  • Published online by Cambridge University Press:
    18 December 2018, pp. b1-b2
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Front Cover (OFC, IFC) and matter

  • PSM volume 49 issue 2 Cover and Front matter

  • Published online by Cambridge University Press:
    20 December 2018, pp. f1-f2
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Back Cover (IBC, OBC) and matter

  • PSM volume 49 issue 2 Cover and Back matter

  • Published online by Cambridge University Press:
    20 December 2018, pp. b1-b2
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Page 17 of 17