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Genetic and environmental influences on obsessive-compulsive symptoms in adults: a population-based twin-family study

Published online by Cambridge University Press:  25 June 2007

DANIËL S. VAN GROOTHEEST ,
DANIËLLE C. CATH ,
AARTJAN T. BEEKMAN  and
DORRET I. BOOMSMA
DANIËL S. VAN GROOTHEEST*
Affiliation:
Department of Biological Psychology, Vrije Universiteit Amsterdam, The Netherlands Department of Psychiatry, Vrije Universiteit Amsterdam, The Netherlands
DANIËLLE C. CATH
Affiliation:
Department of Psychiatry, Vrije Universiteit Amsterdam, The Netherlands
AARTJAN T. BEEKMAN
Affiliation:
Department of Psychiatry, Vrije Universiteit Amsterdam, The Netherlands
DORRET I. BOOMSMA
Affiliation:
Department of Biological Psychology, Vrije Universiteit Amsterdam, The Netherlands
*
*Address for correspondence: Daniël van Grootheest, M.D., Vrije Universiteit Amsterdam, Department of Biological Psychology, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands. (Email: [email protected])
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Abstract

Background

The contribution of genetic factors to obsessive-compulsive (OC) symptoms has not been examined using a large population-based sample of adults. Furthermore, the extent to which there are qualitative and quantitative differences in genetic architecture between men and women with OC symptoms has not been elucidated.

Method

We obtained the Young Adult Self Report Obsessive-Compulsive Scale (YASR-OCS) from a group of 5893 monozygotic (MZ) and dizygotic (DZ) twins, and 1304 additional siblings from the population-based Netherlands Twin Register. Structural equation modelling was used to decompose the variation in OC behaviour into genetic and environmental components and analyse quantitative and qualitative sex differences.

Results

Familial resemblance was the same for DZ twins and non-twin siblings, which means that there was no evidence for a special twin environment. The same genetic risk factors for OC behaviour were expressed in men and women. Depending on the choice of fit index, we found small (39% for men and 50% for women) or no sex differences (47% for both men and women) in heritability. The remaining variance in liability was due to individual-specific environment.

Conclusions

OC behaviour showed a moderate heritability. At most, small quantitative sex differences were found in the genetic architecture of OC behaviour, and no qualitative sex differences.

Type
Original Article
Information
Psychological Medicine , Volume 37 , Issue 11 , November 2007 , pp. 1635 - 1644
Copyright
Copyright © Cambridge University Press 2007

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References

REFERENCES

Achenbach, T. M. (1991). Manual for the Child Behavior Checklist/4–18 and 1991 Profile. Department of Psychiatry, University of Vermont: Burlington, VT.Google Scholar
Achenbach, T. M. (1997). Manual for the Young Adult Self Report and Young Adult Behavior Checklist. Department of Psychiatry, University of Vermont: Burlington, VT.Google Scholar
Achenbach, T. M., McConaughy, S. H. & Howell, C. T. (1987). Child/adolescent behavioral and emotional problems: implications of cross-informant correlations for situational specificity. Psychological Bulletin 101, 213–232.CrossRefGoogle ScholarPubMed
Alsobrook, J. P., Zohar, A. H., Leboyer, M., Chabane, N., Ebstein, R. P. & Pauls, D. L. (2002). Association between the COMT locus and obsessive-compulsive disorder in females but not males. American Journal of Medical Genetics 114, 116–120.CrossRefGoogle Scholar
Arnold, P. D., Sicard, T., Burroughs, E., Richter, M. A. & Kennedy, J. L. (2006). Glutamate transporter gene SLC1A1 associated with obsessive-compulsive disorder. Archives of General Psychiatry 63, 769–776.CrossRefGoogle ScholarPubMed
Black, D. W., Noyes, R. Jr., Goldstein, R. B. & Blum, N. (1992). A family study of obsessive-compulsive disorder. Archives of General Psychiatry 49, 362–368.CrossRefGoogle ScholarPubMed
Bolton, D., Rijsdijk, F., O'Connor, T. G., Perrin, S. & Eley, T. C. (2007). Obsessive-compulsive disorder, tics and anxiety in 6-year-old twins. Psychological Medicine 37, 39–48.CrossRefGoogle ScholarPubMed
Boomsma, D. I., Beem, A. L., van den Berg, M., Dolan, C. V., Koopmans, J. R., Vink, J. M., de Geus, E. J. & Slagboom, P. E. (2000). Netherlands twin family study of anxious depression (NETSAD). Twin Research 3, 323–334.CrossRefGoogle ScholarPubMed
Boomsma, D. I., de Geus, E. J., Vink, J. M., Stubbe, J. H., Distel, M. A., Hottenga, J. J., Posthuma, D., van Beijsterveldt, C. E., Hudziak, J. J., Bartels, M. & Willemsen, G. (2006). Netherlands Twin Register: from twins to twin families. Twin Research and Human Genetics 9, 849–857.CrossRefGoogle ScholarPubMed
Boomsma, D. I., Vink, J. M., van Beijsterveldt, T. C., de Geus, E. J., Beem, A. L., Mulder, E. J., Derks, E. M., Riese, H., Willemsen, G. A., Bartels, M., van den Berg, M., Kupper, N. H., Polderman, T. J., Posthuma, D., Rietveld, M. J., Stubbe, J. H., Knol, L. I., Stroet, T. & Van Baal, G. C. (2002). Netherlands Twin Register: a focus on longitudinal research. Twin Research 5, 401–406.CrossRefGoogle Scholar
Camarena, B., Rinetti, G., Cruz, C., Gomez, A., de La Fuente, J. R. & Nicolini, H. (2001). Additional evidence that genetic variation of MAO-A gene supports a gender subtype in obsessive-compulsive disorder. American Journal of Medical Genetics 105, 279–282.CrossRefGoogle ScholarPubMed
Chabane, N., Delorme, R., Millet, B., Mouren, M. C., Leboyer, M. & Pauls, D. (2005). Early-onset obsessive-compulsive disorder: a subgroup with a specific clinical and familial pattern? Journal of Child Psychology and Psychiatry 46, 881–887.CrossRefGoogle ScholarPubMed
Clifford, C. A., Murray, R. M. & Fulker, D. W. (1984). Genetic and environmental influences on obsessional traits and symptoms. Psychological Medicine 14, 791–800.CrossRefGoogle ScholarPubMed
Cooper, J. (1970). The Leyton obsessional inventory. Psychological Medicine 1, 48–64.CrossRefGoogle ScholarPubMed
Crino, R., Slade, T. & Andrews, G. (2005). The changing prevalence and severity of obsessive-compulsive disorder criteria from DSM-III to DSM-IV. American Journal of Psychiatry 162, 876–882.CrossRefGoogle ScholarPubMed
Delorme, R., Golmard, J. L., Chabane, N., Millet, B., Krebs, M. O., Mouren-Simeoni, M. C. & Leboyer, M. (2005). Admixture analysis of age at onset in obsessive-compulsive disorder. Psychological Medicine 35, 237–243.CrossRefGoogle ScholarPubMed
Derks, E. M., Dolan, C. V. & Boomsma, D. I. (2004). Effects of censoring on parameter estimates and power in genetic modeling. Twin Research 7, 659–669.CrossRefGoogle ScholarPubMed
Dickel, D. E., Veenstra-VanderWeele, J., Cox, N. J., Wu, X., Fischer, D. J., Etten-Lee, M., Himle, J. A., Leventhal, B. L., Cook, E. H. Jr. & Hanna, G. L. (2006). Association testing of the positional and functional candidate gene SLC1A1/EAAC1 in early-onset obsessive-compulsive disorder. Archives of General Psychiatry 63, 778–785.CrossRefGoogle ScholarPubMed
Dolan, C. V., Boomsma, D. I. & Neale, M. C. (1999). A note on the power provided by sibships of sizes 2, 3, and 4 in genetic covariance modeling of a codominant QTL. Behavior Genetics 29, 163–170.CrossRefGoogle Scholar
Eichstedt, J. A. & Arnold, S. L. (2001). Childhood-onset obsessive-compulsive disorder: a tic-related subtype of OCD? Clinical Psychology Review 21, 137–157.CrossRefGoogle ScholarPubMed
Enoch, M. A., Greenberg, B. D., Murphy, D. L. & Goldman, D. (2001). Sexually dimorphic relationship of a 5-HT2A promoter polymorphism with obsessive-compulsive disorder. Biological Psychiatry 49, 385–388.CrossRefGoogle ScholarPubMed
Ferdinand, R. F. & Verhulst, F. C. (1995). Psychopathology from adolescence into young adulthood: an 8-year follow-up study. American Journal of Psychiatry 152, 1586–1594.Google ScholarPubMed
First, M. B., Spitzer, R. L., Gibbon, M. & Williams, J. B. W. (1996). Clinical Interview for DSM-IV Axis I Disorders, Clinician Version (SCID-CV). American Psychiatric Press: Washington, DC.Google Scholar
Geller, D. A., Biederman, J., Faraone, S., Agranat, A., Cradock, K., Hagermoser, L., Kim, G., Frazier, J. & Coffey, B. J. (2001). Developmental aspects of obsessive compulsive disorder: findings in children, adolescents, and adults. Journal of Nervous and Mental Disease 189, 471–477.CrossRefGoogle ScholarPubMed
Geller, D. A., Biederman, J., Jones, J., Shapiro, S., Schwartz, S. & Park, K. S. (1998). Obsessive-compulsive disorder in children and adolescents: a review. Harvard Review of Psychiatry 5, 260–273.CrossRefGoogle ScholarPubMed
Geller, D. A., Doyle, R., Shaw, D., Mullin, B., Coffey, B. J., Petty, C., Vivas, F. & Biederman, J. (2006). A quick and reliable screening measure for OCD in youth: reliability and validity of the Obsessive Compulsive Scale of the Child Behavior Checklist. Comprehensive Psychiatry 47, 234–240.CrossRefGoogle ScholarPubMed
Hanna, G. L., Fingerlin, T. E., Himle, J. A. & Boehnke, M. (2005). Complex segregation analysis of obsessive-compulsive disorder in families with pediatric probands. Human Heredity 60, 1–9.CrossRefGoogle ScholarPubMed
Hemmings, S. M. & Stein, D. J. (2006). The current status of association studies in obsessive-compulsive disorder. Psychiatric Clinics of North America 29, 411–444.CrossRefGoogle ScholarPubMed
Hettema, J. M., Prescott, C. A. & Kendler, K. S. (2001). A population-based twin study of generalized anxiety disorder in men and women. Journal of Nervous and Mental Disease 189, 413–420.CrossRefGoogle ScholarPubMed
Hudziak, J. J., Althoff, R. R., Stanger, C., van Beijsterveldt, C. E., Nelson, E. C., Hanna, G. L., Boomsma, D. I. & Todd, R. D. (2006). The Obsessive Compulsive Scale of the Child Behavior Checklist predicts obsessive-compulsive disorder: a receiver operating characteristic curve analysis. Journal of Child Psychology and Psychiatry 47, 160–166.CrossRefGoogle ScholarPubMed
Hudziak, J. J., van Beijsterveldt, C. E. M., Althoff, R. R., Stanger, C., Rettew, D. C., Nelson, E. C., Todd, R. D., Bartels, M. & Boomsma, D. I. (2004). Genetic and environmental contributions to the Child Behavior Checklist Obsessive-Compulsive Scale: a cross-cultural twin study. Archives of General Psychiatry 61, 608–616.CrossRefGoogle Scholar
Jonnal, A. H., Gardner, C. O., Prescott, C. A. & Kendler, K. S. (2000). Obsessive and compulsive symptoms in a general population sample of female twins. American Journal of Medical Genetics 96, 791–796.3.0.CO;2-C>CrossRefGoogle Scholar
Kendler, K. S. (2005). Psychiatric genetics: a methodologic critique. American Journal of Psychiatry 162, 3–11.CrossRefGoogle ScholarPubMed
Kendler, K. S., Gardner, C. O. & Prescott, C. A. (2001). Panic syndromes in a population-based sample of male and female twins. Psychological Medicine 31, 989–1000.CrossRefGoogle Scholar
Kendler, K. S. & Prescott, C. A. (1999). A population-based twin study of lifetime major depression in men and women. Archives of General Psychiatry 56, 39–44.CrossRefGoogle ScholarPubMed
Lange, J. (1929). The importance of twin pathology for psychiatry [in German]. Allgemeine Zeitschrift für Psychiatrie und psychisch-gerichtliche Medicin 90, 122–142.Google Scholar
Lochner, C., Hemmings, S. M., Kinnear, C. J., Moolman-Smook, J. C., Corfield, V. A., Knowles, J. A., Niehaus, D. J. & Stein, D. J. (2004). Corrigendum to ‘gender in obsessive-compulsive disorder: clinical and genetic findings’ [Eur. Neuropsychopharmacol. 14 (2004) 105–113]. European Neuropsychopharmacology 14, 437–445.CrossRefGoogle ScholarPubMed
Maes, H. H., Neale, M. C., Kendler, K. S., Hewitt, J. K., Silberg, J. L., Foley, D. L., Meyer, J. M., Rutter, M., Simonoff, E., Pickles, A. & Eaves, L. J. (1998). Assortative mating for major psychiatric diagnoses in two population-based samples. Psychological Medicine 28, 1389–1401.CrossRefGoogle ScholarPubMed
Mataix-Cols, D., do Rosario-Campos, M. C. & Leckman, J. F. (2005). A multidimensional model of obsessive-compulsive disorder. American Journal of Psychiatry 162, 228–238.CrossRefGoogle ScholarPubMed
McFall, R. M. & Treat, T. A. (1999). Quantifying the information value of clinical assessments with signal detection theory. Annual Review of Psychology 50, 215–241.CrossRefGoogle ScholarPubMed
Middeldorp, C. M., Cath, D. C., van den Berg, M., Beem, A. L., Van Dyck, R. & Boomsma, D. I. (2006). The association of personality and individual differences. In The Biological Basis of Personality and Individual Differences (ed. Canli, T.), pp. 251–272. Guilford Press: New York.Google Scholar
Miguel, E. C., Leckman, J. F., Rauch, S., do Rosario-Campos, M. C., Hounie, A. G., Mercadante, M. T., Chacon, P. & Pauls, D. L. (2005). Obsessive-compulsive disorder phenotypes: implications for genetic studies. Molecular Psychiatry 10, 258–275.CrossRefGoogle ScholarPubMed
Nance, W. E. & Neale, M. C. (1989). Partitioned twin analysis: a power study. Behavior Genetics 19, 143–150.CrossRefGoogle ScholarPubMed
Neale, M. C., Boker, S. M., Xie, G. & Maes, H. M. (2003). Mx: Statistical Modeling (6th edn). Department of Psychiatry, : Richmond, VA.Google Scholar
Nelson, E. C., Hanna, G. L., Hudziak, J. J., Botteron, K. N., Heath, A. C. & Todd, R. D. (2001). Obsessive-compulsive scale of the child behavior checklist: specificity, sensitivity, and predictive power. Pediatrics 108, E14.CrossRefGoogle ScholarPubMed
Nestadt, G., Bienvenu, O. J., Cai, G., Samuels, J. & Eaton, W. W. (1998). Incidence of obsessive-compulsive disorder in adults. Journal of Nervous and Mental Disease 186, 401–406.CrossRefGoogle ScholarPubMed
Nestadt, G., Lan, T., Samuels, J., Riddle, M., Bienvenu, O. J. III, Liang, K. Y., Hoehn-Saric, R., Cullen, B., Grados, M., Beaty, T. H. & Shugart, Y. Y. (2000 a). Complex segregation analysis provides compelling evidence for a major gene underlying obsessive-compulsive disorder and for heterogeneity by sex. American Journal of Human Genetics 67, 1611–1616.CrossRefGoogle Scholar
Nestadt, G., Samuels, J., Riddle, M., Bienvenu, O. J. III, Liang, K. Y., LaBuda, M., Walkup, J., Grados, M. & Hoehn-Saric, R. (2000 b). A family study of obsessive-compulsive disorder. Archives of General Psychiatry 57, 358–363.CrossRefGoogle ScholarPubMed
Pauls, D. L., Alsobrook, J. P., Goodman, W., Rasmussen, S. & Leckman, J. F. (1995). A family study of obsessive-compulsive disorder. American Journal of Psychiatry 152, 76–84.Google ScholarPubMed
Posthuma, D. & Boomsma, D. I. (2000). A note on the statistical power in extended twin designs. Behavior Genetics 30, 147–158.CrossRefGoogle ScholarPubMed
Sanavio, E. (1988). Obsessions and compulsions: the Padua Inventory. Behaviour Research and Therapy 26, 169–177.CrossRefGoogle ScholarPubMed
Stoel, R. D., de Geus, E. J. & Boomsma, D. I. (2006). Genetic analysis of sensation seeking with an extended twin design. Behavior Genetics 36, 229–237.CrossRefGoogle ScholarPubMed
Storch, E. A., Murphy, T. K., Bagner, D. M., Johns, N. B., Baumeister, A. L., Goodman, W. K. & Geffken, G. R. (2006). Reliability and validity of the Child Behavior Checklist Obsessive-Compulsive Scale. Journal of Anxiety Disorders 20, 473–485.CrossRefGoogle ScholarPubMed
Swets, J. A. (1996). Signal Detection Theory and ROC Analysis in Psychological Diagnostics: Collected Papers. Erlbaum: Mahwah, NJ.Google Scholar
Torres, A. R., Prince, M. J., Bebbington, P. E., Bhugra, D., Brugha, T. S., Farrell, M., Jenkins, R., Lewis, G., Meltzer, H. & Singleton, N. (2006). Obsessive-compulsive disorder: prevalence, comorbidity, impact, and help-seeking in the British National Psychiatric Morbidity Survey of 2000. American Journal of Psychiatry 163, 1978–1985.CrossRefGoogle ScholarPubMed
van den Oord, E. J., Pickles, A. & Waldman, I. D. (2003). Normal variation and abnormality: an empirical study of the liability distributions underlying depression and delinquency. Journal of Child Psychology and Psychiatry 44, 180–192.CrossRefGoogle ScholarPubMed
van Grootheest, D. S., Bartels, M., Cath, D. C., Beekman, A. T., Hudziak, J. J. & Boomsma, D. I. (2007). Genetic and environmental contributions underlying stability in childhood obsessive-compulsive behavior. Biological Psychiatry 61, 308–315.CrossRefGoogle ScholarPubMed
van Grootheest, D. S., Cath, D. C., Beekman, A. T. & Boomsma, D. I. (2005). Twin studies on obsessive-compulsive disorder: a review. Twin Research and Human Genetics 8, 450–458.CrossRefGoogle ScholarPubMed
WHO (1992). Composite International Diagnostic Interview (Version 2.1). World Health Organization: Geneva.Google Scholar
Willemsen, G., Posthuma, D. & Boomsma, D. I. (2005). Environmental factors determine where the Dutch live: results from the Netherlands twin register. Twin Research and Human Genetics 8, 312–317.CrossRefGoogle ScholarPubMed
Wiznitzer, M., Verhulst, F. C., van den Brink, W., Koeter, M., van der Ende, J., Giel, R. & Koot, H. M. (1992). Detecting psychopathology in young adults: the Young Adult Self Report, the General Health Questionnaire and the Symptom Checklist as screening instruments. Acta Psychiatrica Scandinavica 86, 32–37.CrossRefGoogle Scholar