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Repetitive transcranial magnetic stimulation for the treatment of obsessive compulsive disorder: a double-blind controlled investigation

Published online by Cambridge University Press:  26 July 2007

PERMINDER S. SACHDEV ,
COLLEEN K. LOO ,
PHILIP B. MITCHELL ,
TARA F. McFARQUHAR  and
GIN S. MALHI
PERMINDER S. SACHDEV*
Affiliation:
School of Psychiatry, University of New South Wales, Australia Neuropsychiatric Institute, Northern Clinical School, Sydney, Australia
COLLEEN K. LOO
Affiliation:
School of Psychiatry, University of New South Wales, Australia Black Dog Institute, Prince of Wales Hospital; Northern Clinical School, Sydney, Australia
PHILIP B. MITCHELL
Affiliation:
School of Psychiatry, University of New South Wales, Australia Black Dog Institute, Prince of Wales Hospital; Northern Clinical School, Sydney, Australia
TARA F. McFARQUHAR
Affiliation:
School of Psychiatry, University of New South Wales, Australia Black Dog Institute, Prince of Wales Hospital; Northern Clinical School, Sydney, Australia
GIN S. MALHI
Affiliation:
Black Dog Institute, Prince of Wales Hospital; Northern Clinical School, Sydney, Australia Academic Discipline of Psychological Medicine, Northern Clinical School, Sydney, Australia
*
*Address for correspondence: Dr P. S. Sachdev, NPI, Euroa Centre, Prince of Wales Hospital, Barker Street, Randwick NSW 2031, Australia. (Email: [email protected])
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Abstract

Background

To determine the efficacy and tolerability of repetitive transcranial magnetic stimulation (rTMS) as a treatment for obsessive compulsive disorder (OCD) in a double-blind placebo-controlled study.

Method

Subjects with treatment-resistant OCD were randomized to rTMS (n=10) or sham rTMS (n=8) for 10 sessions of daily stimulation over the left dorsolateral prefrontal cortex (DLPFC), with subjects and raters being blind to the treatment. Subjects were offered an open extension of up to 20 sessions of rTMS.

Results

The two groups did not differ on change in Yale–Brown Obsessive Compulsive Scale (YBOCS) or Maudsley Obsessive-Compulsive Inventory scores over 10 sessions, with or without correction for depression ratings. Over 20 sessions, there was a significant reduction in total YBOCS scores, but not after controlling for depression. rTMS over 20 sessions was well tolerated.

Conclusion

Two weeks of rTMS over the left DLPFC is ineffective for treatment-resistant OCD.

Type
Original Article
Information
Psychological Medicine , Volume 37 , Issue 11 , November 2007 , pp. 1645 - 1649
Copyright
Copyright © Cambridge University Press 2007

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