Hostname: page-component-cd9895bd7-8ctnn Total loading time: 0 Render date: 2024-12-22T15:50:02.709Z Has data issue: false hasContentIssue false
  • English
  • Français

Vitamin E: molecular and biological function

Published online by Cambridge University Press:  28 February 2007

Graham W. Burton
Graham W. Burton*
Affiliation:
Steacie Institute for Molecular Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ontario, CanadaKIA OR6
Rights & Permissions [Opens in a new window]

Abstract

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Meeting Report
Information
Proceedings of the Nutrition Society , Volume 53 , Issue 2 , July 1994 , pp. 251 - 262
Copyright
Copyright © The Nutrition Society 1994

References

Adamstone, F. B. & Card, L. E. (1934). The effects of vitamin E deficiency on the testes of the male fowl (Gallus domesticus). Journal of Morphology 56, 339–359.Google Scholar
Ames, B. N., Shigenaga, M. K. & Hagen, T. M. (1993). Oxidants, antioxidants, and the degenerative diseases of aging. Proceedings of the National Academy of Sciences, USA 90, 7915–7922.Google Scholar
Behrens, W. A. & Madère, R. (1982). Occurrence of a rat liver α-tocopherol binding protein in vivo. Nutrition Reports International 25, 107–112.Google Scholar
Behrens, W. A. & Madère, R. (1983). Interrelationship and competition of α- and γ-tocopherol at the level of intestinal absorption, plasma transport and liver uptake. Nutrition Research 3, 891–897.Google Scholar
Bowry, V. W., Ingold, K. U. & Stocker, R. (1992). Vitamin E in human low-density lipoprotein. When and how this antioxidant becomes a pro-oxidant. Biochemical Journal 288, 341–344.Google Scholar
Bowry, V. W. & Stocker, R. (1993). Tocopherol-mediated peroxidation. The prooxidant effect of vitamin E on the radical-initiated oxidation of human low-density lipoprotein. Journal of the American Chemical Society 115, 6029–6044.Google Scholar
Bunyan, J., McHale, D., Green, J. & Marcinkiewicz, S. (1961). Biological potencies of ε- and ξ1-tocopherol and 5-methyltocol. British Journal of Nutrition 15, 253–257.Google Scholar
Burton, G. W., Doba, T., Gabe, E. J., Hughes, L., Lee, F. L., Prasad, L. & Ingold, K. U. (1985). Autoxidation of biological molecules. 4. Maximizing the antioxidant activity of phenols. Journal of the American Chemical Society 107, 7053–7065.Google Scholar
Burton, G. W. & Ingold, K. U. (1993). Biokinetics of vitamin E using deuterated tocopherols. In Vitamin E in Health and Disease, pp. 329–344 [Packer, L., and Fuchs, J., editors]. New York: Marcel Dekker.Google Scholar
Burton, G. W., Ingold, K. U., Zahalka, H., Dutton, P., Hodgkinson, B., Hughes, L., Foster, D. O. & Behrens, W. A. (1993). Biodiscrimination of tocopherols. In Vitamin E. Its Usefulness in Health and in Curing Diseases, pp. 51–61 [Mino, M., Nakamura, H., Diplock, A. T. and Kayden, H. J., editors]. Tokyo: Japan Scientific Society Press.Google Scholar
Burton, G. W., Joyce, A. & Ingold, K. U. (1983). Is vitamin E the only lipid-soluble, chain-breaking antioxidant in human blood plasma and erythrocyte membranes? Archives of Biochemistry and Biophysics 221, 281–290.CrossRefGoogle ScholarPubMed
Burton, G. W., Wronska, U., Stone, L., Foster, D. O. & Ingold, K. U. (1990). Brokinetics of dietary RRR-α-tocopherol in the male guinea pig at three dietary levels of vitamin C and two levels of vitamin E. Evidence that vitamin C does not ‘spare’ vitamin E in vivo. Lipids 25, 199–210.Google Scholar
Carew, T. E., Schwenke, D. C. & Steinberg, D. (1987). Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit. Proceedings of the National Academy of Sciences, USA 84, 7725–7729.Google Scholar
Catignani, G. L. (1975). An α-tocopherol binding protein in rat liver cytoplasm. Biochemical and Biophysical Research Communications 67, 66–72.CrossRefGoogle ScholarPubMed
Century, B. & Horwitt, M. K. (1965). Biological availability of various forms of vitamin E with respect to different indices of deficiency. Federation Proceedings 24, 906–911.Google Scholar
Chatelain, E., Boscoboinik, D. O., Bartoli, G. M., Kagan, V. E., Gey, F. K., Packer, L. & Azzi, A. (1993). Inhibition of smooth muscle cell proliferation and protein kinase C activity by tocopherols and tocotrienols. Biochemica el Biophysica Acta 1176, 83–89.Google Scholar
Cheeseman, K. H., Burton, G. W., Ingold, K. U. & Slater, T. F. (1984). Lipid peroxidation and lipid antioxidants in normal tumor cells. Toxicologic Pathology 12, 235–239.Google Scholar
Diplock, A. T. (1985). Vitamin E. In Fat-soluble Vitamins, pp. 154–224 [Diplock, A. T., editor]. Lancaster, Pennsylvania: Technomic Publishing Co. Google Scholar
Drevon, C. A. (1993). Absorption, metabolism, and excretion of vitamin E. In Vitamin E, pp. 65–83 [Mino, M., Nakamura, H., Diplock, A. T. and Kayden, H. J., editors]. Tokyo: Japan Scientific Society Press.Google Scholar
Eskelson, C. D., Odeleye, O. E., Watson, R. R., Earnest, D. L. & Mufti, S. I. (1993). Modulation of cancer growth by vitamin E and alcohol. Alcohol and Alcoholism 28, 117–125.Google ScholarPubMed
Evans, H. M. & Bishop, K. S. (1922). On the existence of a hitherto unrecognized dietary factor essential for reproduction. Science 56, 650–651.Google Scholar
Fairburn, K., Grootveld, M., Ward, R. J., Abiuka, C., Kus, M., Williams, R. B., Winyard, P. G. & Blake, D. R. (1992). α-Tocopherol, lipids and lipoproteins in knee-joint synovial fluid and serum from patients with inflammatory joint disease. Clinical Science 83, 657–664.Google Scholar
Feingold, I. B., Longhurst, P. A. & Colby, H. D. (1993). Regulation of adrenal and hepatic α-tocopherol content by androgens and estrogens. Biochimica et Biophysica Acta 1176, 192–196.Google Scholar
Gerrish, K. E. & Gender, H. L. (1993). Prevention of photocarcinogenesis by dietary vitamin E. Nutrition and Cancer 19, 125–133.Google Scholar
Gey, K. F., Puska, P., Jordan, P. & Moser, U. K. (1991). Inverse correlation between plasma vitamin E and mortality from ischemic heart disease in cross-cultural epidemiology. American Journal of Clinical Nutrition 53, 326S–334S.Google Scholar
Goettsch, M. & Pappenheimer, A. M. (1931). Nutritional muscular dystrophy in the guinea pig and rabbit. Journal of Experimental Medicine 54, 145–165.Google Scholar
Gotto, A. M., Pownall, H. P. & Havel, R. J. (1986). Introduction to the plasma lipoproteins. In Methods in Enzymology, pp. 3–41 [Segrest, J. P., and Albers, J. J., editors]. New York: Academic Press, Inc. Google Scholar
Ingold, K. U., Bowry, V. W., Stocker, R. & Walling, C. (1993). Autoxidation of lipids and antioxidation by α-tocopherol and ubiquinol in homogeneous solution and in aqueous dispersions of lipids. Unrecognized consequences of lipid particle size as exemplified by oxidation of human low density lipoprotein. Proceedings of the National Academy of Sciences, USA 90, 45–49.Google Scholar
Ingold, K. U., Burton, G. W., Foster, D. O., Hughes, L., Lindsay, D. A. & Webb, A. (1987). Biokinetics of and discrimination between dietary RRR- and SRR-α-tocopherols in the male rat. Lipids 22, 163–172.CrossRefGoogle ScholarPubMed
Kayden, H. J. & Traber, M. G. (1993). Absorption, lipoprotein transport, and regulation of plasma concentrations of vitamin E in humans. Journal of Lipid Research 34, 343–358.Google Scholar
Knekt, P. (1993). Epidemiology of vitamin E: evidence for anticancer effects in humans. In Vitamin E in Health and Disease, pp. 513–527 [Packer, L., and Fuchs, J., editors]. New York: Marcel Dekker.Google Scholar
Mason, K. E. (1933). Differences in testis injury and repair after vitamin A deficiency, vitamin E deficiency and inanition. American Journal of Anatomy 52, 153.Google Scholar
Meydani, M., Meydani, S. N. & Blumberg, J. B. (1993). Modulation by dietary vitamin E and selenium of clotting whole blood thromboxane A2 and aortic prostacyclin synthesis in rats. Journal of Nutritional Biochemistry 4, 322–326.Google Scholar
Meydani, S. N. & Tengerdy, R. P. (1993). Vitamin E and immune response. In Vitamin E in Health and Disease, pp. 549–561 [Packer, L. and Fuchs, J., editors]. New York: Marcel Dekker.Google Scholar
Mitchel, R. E. J. & McCann, R. (1993). Vitamin E is a complete tumor promoter in mouse skin. Carcinogenesis 14, 659–662.Google Scholar
Mowri, H., Nakagawa, Y., Inoue, K. & Nojima, S. (1981). Enhancement of the transfer of α-tocopherol between liposomes and mitochondria by rat-liver protein(s). European Journal of Biochemistry 117, 537–542.Google Scholar
Odeleye, O. E., Eskelson, C. D., Mufti, S. I. & Watson, R. R. (1992). Vitamin E protection against nitrosamine-induced esophageal tumor incidence in mice immunocompromised by retroviral infection. Carcinogenesis 13, 1811–1816.Google Scholar
Olcott, H. S. & Emerson, O. H. (1937). Antioxidants and the autoxidation of fats. IX. The antioxidant properties of the tocopherols. Journal of the American Chemical Society 59, 1008–1009.Google Scholar
Olcott, H. S. & Mattill, H. A. (1931). The unsaponifiable lipids of lettuce. III. Antioxidants. Journal of Biological Chemistry 93, 65–70.Google Scholar
Pappenheimer, A. M. & Goettsch, M. (1931). A cerebellar disorder in chicks, apparently of nutritional origin. Journal of Experimental Medicine 53, 11–16.Google Scholar
Rice-Evans, C. & Burdon, R. (1993). Free radical-lipid interactions and their pathological consequences. Progress in Lipid Research 32, 71–110.Google Scholar
Rimm, E. B., Stampfer, M. J., Ascherio, A., Giovannucci, E., Colditz, G. A. & Willett, W. C. (1993). Vitamin E consumption and the risk of coronary heart disease in men. New England Journal of Medicine 328, 1450–1456.Google Scholar
Sato, Y., Hagiwara, K., Arai, H. & Inoue, K. (1991). Purification and characterization of the α-tocopherol transfer protein from rat liver. FEBS Letters 288, 41–45.Google Scholar
Sawyer, D. T., Kang, C., Llobet, A. & Redman, C. (1993). Fenton reagents (1:l FeIILx/HOOH) react via [LxFeIIOOH(BH+)] (1) as hydroxylases (RH→ROH), not as generators of free hydroxyl radicals (HO·). Journal of the American Chemical Society 115, 5817–5818.Google Scholar
Scott, M. L. (1978). Vitamin E. In The Fat-soluble Vitamins, pp. 133–210 [DeLuca, H. F., editor]. New York: Plenum Press.Google Scholar
Sparrow, C. P., Doebber, T. W., Olszewski, J., Wu, M. S., Ventre, J., Stevens, K. A. & Chao, Y. S. (1992). Low density lipoprotein is protected from oxidation and the progression of atherosclerosis is slowed in cholesterol-fed rabbits by the antioxidant N, N'-diphenylphenylenediamine. Journal of Clinical Investigation 89, 1885–1891.Google Scholar
Stampfer, M. J., Hennekens, C. H., Manson, J. E., Colditz, G. A., Rosner, B. & Willett, W. C. (1993). Vitamin E consumption and the risk of coronary disease in women. New England Journal of Medicine 328, 1444–1449.Google Scholar
Steinberg, D., Berliner, J. A., Burton, G. W., Carew, T. E., Chait, A., Chisolm, G. M., Esterbauer, H., Fogelman, A. M., Fox, P. L., Furberg, C. D., Gaziano, J. M., Gey, K. F., Grundy, S. M., Harlan, W. R., Havel, R. J., Hennekens, C. H., Hoff, H. F., Jackson, R. L., Kayden, H. J. & Keech, A. (1992). Antioxidants in the prevention of human atherosclerosis. Summary of the proceedings of a National Heart, Lung, and Blood Institute Workshop: September 5–6, 1991, Bethesda, Maryland. Circulation 85, 2338–2344.Google Scholar
Steinberg, D., Parthasarathy, S., Carew, T. E., Khoo, J. C. & Witztum, J. L. (1989). Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. New England Journal of Medicine 320, 915–924.Google Scholar
Traber, M. G., Burton, G. W., Hughes, L., Ingold, K. U., Hidaka, H., Malloy, M., Kane, J., Hyams, J. & Kayden, H. J. (1992). Discrimination between forms of vitamin E by humans with and without genetic abnormalities of lipoprotein metabolism. Journal of Lipid Research 33, 1171–1182.Google Scholar
Traber, M. G., Burton, G. W., Ingold, K. U. & Kayden, H. J. (1990 a). RRR- and SRR-α-tocopherols are secreted without discrimination in human chylomicrons, but RRR-α-tocopherol is preferentially secreted in very low density lipoproteins. Journal of Lipid Research 31, 675–685.CrossRefGoogle ScholarPubMed
Traber, M. G., Cohn, W. & Muller, D. P. R. (1993 a). Absorption, transport and delivery to tissues. In Vitamin E in Health and Disease, pp. 35–51 [Packer, L., and Fuchs, J., editors]. New York: Marcel Dekker.Google Scholar
Traber, M. G., Rudel, L. L., Burton, G. W., Hughes, L., Ingold, K. U. & Kayden, H. J. (1990 b). Nascent VLDL from liver perfusions of cynomolgus monkeys are preferentially enriched in RRR- compared with SRR-α tocopherol. Studies using deuterated tocopherols. Journal of Lipid Research 31, 687–694.Google Scholar
Traber, M. G., Sokol, R. J., Kohlschutter, A., Yokota, T., Muller, D. P. R., Dufour, R. & Kayden, H. J. (1993 b). Impaired discrimination between stereoisomers of α-tocopherol in patients with familial isolated vitamin E deficiency. Journal of Lipid Research 34, 201–210.Google Scholar
Verlangieri, A. J. & Bush, M. J. (1992). Effects of d-α-tocopherol supplementation on experimentally induced primate atherosclerosis. Journal of the American College of Nutrition 11, 131–138.CrossRefGoogle ScholarPubMed
Watson, R. R., Odeleye, O. E., Eskelson, C. D. & Mufti, S. I. (1992). Alcohol stimulation of lipid peroxidation and esophageal tumor growth in mice immunocompromised by retrovirus infection. Alcohol 9, 495–500.Google Scholar
Williams, R. J., Motteram, J. M., Sharp, C. H. & Gallagher, P. J. (1992). Dietary vitamin E and the attenuation of early lesion development in modified Watanabe rabbits. Atherosclerosis 94, 153–159.Google Scholar