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Symposium 2 Newer aspects of micronutrients in at risk groups

New metabolic roles for selenium

Published online by Cambridge University Press:  28 February 2007

John R. Arthur
Affiliation:
Division of Biochemical Sciences, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB2 9SB
Geoffrey J. Beckett
Affiliation:
University Department of Clinical Biochemistry, The Royal Infirmary, Edinburgh EH3 9YW
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Abstract

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Type
‘Newer aspects of micronutrients’
Copyright
Copyright © The Nutrition Society 1994

References

Akesson, B., Bellew, T. & Burk, R. F. (1994). Purification of selenoprotein P from human plasma. Biochimica et Biophysica Acta 1204, 243249.CrossRefGoogle ScholarPubMed
Arthur, J. R. (1991). The role of selenium in thyroid hormone metabolism. Canadian Journal of Physiology and Pharmacology 69, 16481652.CrossRefGoogle ScholarPubMed
Arthur, J. R. & Beckett, G. J. (1989). Selenium deficiency and thyroid hormone metabolism. In Selenium in Biology and Medicine, pp. 9095 [Wendel, A., editor]. Heidelberg: Springer-Verlag.CrossRefGoogle Scholar
Arthur, J. R. & Beckett, G. J. (1994). Roles of selenium in type I iodothyronine 5' deiodinase and in thyroid hormone and iodine metabolism. In Selenium in Biology and Human Health, pp. 93115 [Burk, R. F., editor]. New York: Springer-Verlag.CrossRefGoogle Scholar
Arthur, J. R., Boyne, R., Morrice, P. & Nicol, F. (1986). Selenium and neutrophil function in mice. Proceedings of the Nutrition Society 45, 63A.Google Scholar
Arthur, J. R., Morrice, P. C., Nicol, F., Beddows, S. E., Boyd, R., Hayes, J. D. & Beckett, G. J. (1987 a). The effects of selenium and copper deficiencies on glutathione S-transferase and glutathione peroxidase in rat liver. Biochemical Journal 248, 539544.CrossRefGoogle ScholarPubMed
Arthur, J. R., Nicol, F. & Beckett, G. J. (1990 a). Hepatic iodothyronine deiodinase: The role of selenium. Biochemical Journal 272, 537540.CrossRefGoogle ScholarPubMed
Arthur, J. R., Nicol, F. & Beckett, G. J. (1993). Selenium deficiency, thyroid hormone metabolism, and thyroid hormone deiodinases. American Journal of Clinical Nutrition 57, S236S239.CrossRefGoogle ScholarPubMed
Arthur, J. R., Nicol, F., Boyne, R., Allen, K. G. D., Hayes, J. D. & Beckett, G. J. (1987 b). Old and new roles for selenium. In Trace Substances in Environmental Health XXI, pp. 487498 [Hemphill, D. D., editor]. Colombia: University of Missouri.Google Scholar
Arthur, J. R., Nicol, F., Grant, E. & Beckett, G. J. (1991). The effects of selenium deficiency on hepatic type-I iodothyronine deiodinase and protein disulphide-isomerase assessed by activity measurements and affinity labelling. Biochemical Journal 274, 297300.CrossRefGoogle ScholarPubMed
Arthur, J. R., Nicol, F., Hutchinson, A. R. & Beckett, G. J. (1990 b). The effects of selenium depletion and repletion on the metabolism of thyroid hormones in the rat. Journal of Inorganic Biochemistry 39, 101108.CrossRefGoogle Scholar
Avissar, N., Kerl, E. A., Baker, S. S. & Cohen, H. J. (1994 a). Extracellular glutathione peroxidase mRNA and protein in human cell lines. Archives of Biochemistry and Biophysics 309, 239246.CrossRefGoogle ScholarPubMed
Avissar, N., Ornt, D. B., Yagil, Y., Horowitz, S., Watkins, R. H., Kerl, E. A., Takahashi, K., Palmer, I. S. & Cohen, H. J. (1994 b). Human kidney proximal tubules are the main source of plasma glutathione peroxidase. American Journal of Physiology 266, C367C375.CrossRefGoogle ScholarPubMed
Avissar, N., Slemmon, J. R., Palmer, I. S. & Cohen, H. J. (1991). Partial sequence of human plasma glutathione peroxidase and immunologic identification of milk glutathione peroxidase as the plasma enzyme. Journal of Nutrition 121, 12431249.CrossRefGoogle ScholarPubMed
Avissar, N., Whitin, J. C., Allen, P. Z., Wagner, D. D., Liegey, P. & Cohen, H. J. (1989). Plasma selenium-dependent glutathione peroxidase – cell of origin and secretion. Journal of Biological Chemistry 264, 1585015855.CrossRefGoogle ScholarPubMed
Bansal, M. P., Ip, C. & Medina, D. (1991). Levels and Se-75-labeling of specific proteins as a consequence of dietary selenium concentration in mice and rats. Proceedings of the Society for Experimental Biology and Medicine 196, 147154.CrossRefGoogle ScholarPubMed
Bansal, M. P., Mukhopadhyay, T., Scott, J., Cook, R. G., Mukhopadhyay, R. & Medina, D. (1990). DNA sequencing of a mouse liver protein that binds selenium - implications for selenium's mechanism of action in cancer prevention. Carcinogenesis 11, 20712073.CrossRefGoogle ScholarPubMed
Beckett, G. J., Beddows, S. E., Morrice, P. C., Nicol, F. & Arthur, J. R. (1987). Inhibition of hepatic deiodination of thyroxine caused by selenium deficiency in rats. Biochemical Journal 248, 443447.CrossRefGoogle ScholarPubMed
Beckett, G. J., Beech, S., Nicol, F., Walker, S. W. & Arthur, J. R. (1993 a). Species differences in thyroidal iodothyronine deiodinase expression and the effect of selenium deficiency on its activity. Journal of Trace Elements and Electrolytes in Health and Disease 7, 123124.Google Scholar
Beckett, G. J., MacDougall, D. A., Nicol, F. & Arthur, J. R. (1989). Inhibition of type I and type II iodothyronine deiodinase activity in rat liver, kidney and brain produced by selenium deficiency. Biochemical Journal 259, 887892.CrossRefGoogle ScholarPubMed
Beckett, G. J., Nicol, F., Proudfoot, D., Dyson, K., Loucaides, G. & Arthur, J. R. (1990). The changes in hepatic enzyme expression caused by selenium deficiency and hypothyroidism in rats are caused by independent mechanisms. Biochemical Journal 266, 743747.CrossRefGoogle ScholarPubMed
Beckett, G. J., Nicol, F., Rae, P. W. H., Beech, S., Guo, Y. & Arthur, J. R. (1993 b). Effects of combined iodine and selenium deficiency on thyroid hormone metabolism in rats. American Journal of Clinical Nutrition 57, S240S243.CrossRefGoogle ScholarPubMed
Beckett, G. J., Russell, A., Nicol, F., Sahu, P., Wolf, C. R. & Arthur, J. R. (1992). Effect of selenium deficiency on hepatic type-I 5-iodothyronine deiodinase and hepatic thyroid hormone levels in the rat. Biochemical Journal 282, 483486.CrossRefGoogle ScholarPubMed
Beech, S. G., Walker, S. W., Dorrance, A. M., Arthur, J. R., Nicol, F., Lee, D. & Beckett, G. J. (1993). The role of thyroidal type-I iodothyronine deiodinase in tri-iodothyronine production by human and sheep thyrocytes in primary culture. Journal of Endocrinology 136, 361370.CrossRefGoogle ScholarPubMed
Behne, D., Hilmert, H., Scheid, S., Gessner, H. & Elger, W. (1988). Evidence for specific selenium target tissues and new biologically important selenoproteins. Biochimica et Biophysica Acta 966, 1221.CrossRefGoogle ScholarPubMed
Behne, D., Kyriakopoulos, A., Meinhold, H. & Kohrle, J. (1990). Identification of type-I iodothyronine 5'-deiodinase as a selenoenzyme. Biochemical and Biophysical Research Communications 173, 11431149.CrossRefGoogle ScholarPubMed
Benton, D. & Cook, R. (1990). Selenium supplementation improves mood in a double-blind crossover trial. Psychopharmacology 102, 549550.CrossRefGoogle Scholar
Benton, D. & Cook, R. (1991). The impact of selenium supplementation on mood. Biological Psychiatry 29, 10921098.CrossRefGoogle ScholarPubMed
Berry, M. J., Banu, L. & Larsen, P. R. (1991). Type-I iodothyronine deiodinase is a selenocysteine-containing enzyme. Nature 349, 438440.CrossRefGoogle ScholarPubMed
Berry, M. J. & Larsen, P. R. (1992). The role of selenium in thyroid hormone action. Endocrine Reviews 13, 207219.Google ScholarPubMed
Boyne, R. & Arthur, J. R. (1986). The response of selenium deficient mice to Candida albicans infection. Journal of Nutrition 116, 816822.CrossRefGoogle ScholarPubMed
BrigeliusFlohe, R., Aumann, K. D., Blocker, H., Gross, G., Kiess, M., Kloppel, K. D., Maiorino, M., Roveri, A., Schuckelt, R., Ursini, F., Wingender, E. & Flohe, L. (1994). Phospholipid-hydroperoxide glutathione peroxidase – genomic DNA, cDNA, and deduced amino acid sequence. Journal of Biological Chemistry 269, 73427348.CrossRefGoogle ScholarPubMed
Bryant, R. W., Simon, T. C. & Bailey, J. M. (1983). Hydroperoxy fatty acid formation in selenium deficient rat platelets: coupling of glutathione peroxidase to the lipoxygenase pathway. Biochemical and Biophysical Research Communications 117, 183189.CrossRefGoogle Scholar
Burk, R. F. (1989). Recent developments in trace element metabolism and function: Newer roles of selenium in nutrition. Journal of Nutrition 119, 10511054.CrossRefGoogle ScholarPubMed
Burk, R. F. (1991). Molecular biology of selenium with implications for its metabolism. FASEB Journal 5, 22742279.CrossRefGoogle ScholarPubMed
Burk, R. F. & Hill, K. E. (1993). Regulation of selenoproteins. Annual Review of Nutrition 13, 6581.CrossRefGoogle ScholarPubMed
Burk, R. F., Hill, K. E., Read, R. & Bellew, T. (1991). Response of rat selenoprotein-P to selenium administration and fate of its selenium. American Journal of Physiology 261, E26E30.Google ScholarPubMed
Calvin, H. I., Grosshans, K., Musicant-Shikora, S. R. & Turner, S. I. (1987). A developmental study of rat sperm and testis selenoproteins. Journal of Reproduction and Fertility 81, 111.CrossRefGoogle ScholarPubMed
Cao, Y. Z., Maddox, J. F., Mastro, A. M., Scholz, R. W., Hildenbrandt, G. & Reddy, C. C. (1992). Selenium deficiency alters the lipoxygenase pathway and mitogenic response in bovine lymphocytes. Journal of Nutrition 122, 21212127.CrossRefGoogle ScholarPubMed
Chanoine, J. P., Braverman, L. E., Farwell, A. P., Safran, M., Alex, S., Dubord, S. & Leonard, J. L. (1993). The thyroid gland is a major source of circulating-T(3) in the rat. Journal of Clinical Investigation 91, 27092713.CrossRefGoogle Scholar
Chanione, J. P., Safran, M., Farwell, A. P., Dubord, S., Alex, S., Stone, S., Arthur, J. R., Braverman, L. E. & Leonard, J. L. (1992). Effects of selenium deficiency on thyroid hormone economy in rats. Endocrinology 131, 17871792.CrossRefGoogle Scholar
Chu, F. F., Doroshow, J. H. & Esworthy, R. S. (1993). Expression, characterisation and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI. Journal of Biological Chemistry 268, 25712576.CrossRefGoogle ScholarPubMed
Combs, G. F. & Combs, S. B. (1986). The Role of Selenium in Nutrition. New York: Academic Press Inc.Google Scholar
Corvilain, B., Contempre, B., Longombe, A. O., Goyens, P., Gervydecoster, C., Lamy, F., Vanderpas, J. B. & Dumont, J. E. (1993). Selenium and the thyroid: how the relationship was established. American Journal of Clinical Nutrition 57, S244S248.CrossRefGoogle ScholarPubMed
Doroshow, J. H., Akman, S., Esworthy, S., Chu, F. F. & Burke, T. (1991). Doxorubicin resistance conferred by selective enhancement of intracellular glutathione peroxidase or superoxide dismutase content in human MCF-7 breast cancer cells. Free Radical Research Communications 12, 779781.CrossRefGoogle ScholarPubMed
Evenson, J. K. & Sunde, R. A. (1988). Selenium incorporation into selenoproteins in the Se-adequate and Se-deficient rat. Proceedings of the Society for Experimental Biology and Medicine 187, 169180.CrossRefGoogle ScholarPubMed
Geloen, A., Arthur, J. R., Beckett, G. J. & Trayhurn, P. (1990). Effect of selenium and iodine deficiency on the level of uncoupling protein in brown adipose tissue of rats. Biochemical Society Transactions 18, 12691270.CrossRefGoogle ScholarPubMed
Hill, K. E. & Burk, R. F. (1994). Selenoprotein P – an extracellular protein containing multiple selenocysteines. In Selenium in Biology and Human Health, pp. 117131 [Burk, R. F., editor]. New York: Springer-Verlag.CrossRefGoogle Scholar
Hill, K. E., Lloyd, R. S. & Burk, R. F. (1993). Conserved nucleotide sequences in the open reading frame and 3' untranslated region of selenoprotein-P messenger RNA. Proceedings of the National Academy of Sciences, USA 90, 537541.CrossRefGoogle Scholar
Hill, K. E., Lloyd, R. S., Yang, J. G., Read, R. & Burk, R. F. (1991). The cDNA for rat selenoprotein-P contains 10 TGA codons in the opening reading frame. Journal of Biological Chemistry 266, 1005010053.CrossRefGoogle Scholar
Hoekstra, W. G. (1975). Biochemical function of selenium and its relation to vitamin E. Federation Proceedings 34, 20832089.Google ScholarPubMed
Ip, C. & Lisk, D. J. (1994). Characterization of tissue selenium profiles and anticarcinogenic responses in rats fed natural sources of selenium-rich products. Carcinogenesis 15, 573576.CrossRefGoogle ScholarPubMed
Karimpour, I., Cutler, M., Shih, D., Smith, J. & Kleene, K. C., (1992). Sequence of the gene encoding the mitochondrial capsule selenoprotein of mouse sperm: identification of three in-phase TGA selenocysteine codons. DNA and Cell Biology 11, 693699.CrossRefGoogle ScholarPubMed
Lanfear, J., Fleming, J., Walker, M. & Harrison, P. (1993). Different patterns of regulation of the genes encoding the closely related 56-kDa selenium-binding and acetaminophen-binding proteins in normal tissues and during carcinogenesis. Carcinogenesis 14, 335340.CrossRefGoogle Scholar
Maiorino, M., Chu, F. F., Ursini, F., Davies, K. J. A., Doroshow, J. H. & Esworthy, R. S. (1991 a). Phospholipid hydroperoxide glutathione peroxidase is the 18-kDa selenoprotein expressed in human tumor cell lines. Journal of Biological Chemistry 266, 77287732.CrossRefGoogle ScholarPubMed
Maiorino, M., Thomas, J. P., Girotti, A. W. & Ursini, F. (1991 b). Reactivity of phospholipid hydroperoxide glutathione peroxidase with membrane and lipoprotein lipid hydroperoxides. Free Radical Research Communications 12, 131135.CrossRefGoogle ScholarPubMed
Mirault, M. E., Tremblay, A., Beaudoin, N. & Tremblay, M. (1991). Overexpression of seleno-glutathione peroxidase by gene transfer enhances the resistance of T47D human breast cells to clastogenic oxidants. Journal of Biological Chemistry 266, 2075220760.CrossRefGoogle ScholarPubMed
Nicol, F., Lefranc, H., Arthur, J. R. & Trayhurn, P. (1994). Characterisation of Type I deiodinase in goat brown adipose tissue. American Journal of Physiology 267, R144R149.Google Scholar
Reiter, R. & Wendel, A. (1983). Selenium and drug metabolism-I, Multiple modulations of mouse liver enzymes. Biochemical Pharmacology 32, 30633067.CrossRefGoogle ScholarPubMed
Reiter, R. & Wendel, A. (1984). Selenium and drug metabolism-II, Independence of glutathione peroxidase and reversibility of hepatic enzyme modulations in deficient mice. Biochemical Pharmacology 33, 19231928.CrossRefGoogle ScholarPubMed
Reiter, R. & Wendel, A. (1985). Selenium and drug metabolism-III, Relation of glutathione peroxidase and other hepatic enzyme modulations to dietary supplements. Biochemical Pharmacology 34, 22872290.CrossRefGoogle ScholarPubMed
Rotruck, J. T., Pope, A. L., Ganther, H. E., Swanson, A. B., Hafeman, D. G. & Hoekstra, W. G. (1973). Selenium: biochemical role as a component of glutathione peroxidase. Science 179, 588590.CrossRefGoogle ScholarPubMed
Roveri, A., Casasco, A., Maiorino, M., Dalan, P., Calligaro, A. & Ursini, F. (1992). Phospholipid hydroperoxide glutathione peroxidase of rat testis – gonadotropin dependence and immunocytochemical identification. Journal of Biological Chemistry 267, 61426146.CrossRefGoogle ScholarPubMed
Schuckelt, R., BrigeliusFlohe, R., Maiorino, M., Roveri, A., Reumkens, J., Strassburger, W., Ursini, F., Wolf, B. & Flohe, L. (1991). Phospholipid hydroperoxide glutathione peroxidase is a seleno-enzyme distinct from the classical glutathione peroxidase as evident from cDNa and amino acid sequencing. Free Radical Research Communications 14, 343361.CrossRefGoogle Scholar
Sinha, R., Bansal, M. P., Ganther, H. & Medina, D. (1993). Significance of selenium-labelled proteins for selenium's chemopreventive functions. Carcinogenesis 14, 18951900.CrossRefGoogle Scholar
Sunde, R. A. (1990). Molecular biology of selenoproteins. Annual Review of Nutrition 10, 451474.CrossRefGoogle ScholarPubMed
Sunde, R. A. (1994). Intracellular glutathione peroxidases – structure regulation and function. In Selenium in Biology and Human Health, pp. 4577 [Burk, R. F., editor]. New York: Springer-Verlag.CrossRefGoogle Scholar
Sunde, R. A., Dyer, J. A., Moran, T. V., Evenson, J. K. & Sugimoto, M. (1993). Phosopholipid hydroperoxide glutathione peroxidase – full-length pig blastocyst cDNA sequence and regulation by selenium status. Biochemical and Biophysical Research Communications 193, 905911.CrossRefGoogle Scholar
Takahashi, K., Akasaka, M., Yamamoto, Y., Kobayashi, C., Mizoguchi, J. & Koyama, J. (1990). Primary structure of human plasma glutathione peroxidase deduced from cDNA sequences. Journal of Biochemistry 108, 145148.CrossRefGoogle ScholarPubMed
Takahashi, K., Avissar, N., Whitin, J. & Cohen, H. (1987). Purification and characterization of human plasma glutathione peroxidase: A selenoglycoprotein distinct from the known cellular enzyme. Archives of Biochemistry and Biophysics 256, 677686.CrossRefGoogle ScholarPubMed
Takahashi, K. & Cohen, H. J. (1986). Selenium-dependent glutathione peroxidase protein and activity: Immunological investigations on cellular and plasma enzymes. Blood 68, 640645.CrossRefGoogle ScholarPubMed
Thomas, J. P., Maiorino, M., Ursini, F. & Girotti, A. W. (1990). Protective action of phospholipid hydroperoxide glutathione peroxidase against membrane-damaging lipid peroxidation – in situ reduction of phospholipid and cholesterol hydroperoxides. Journal of Biological Chemistry 265, 454461.CrossRefGoogle ScholarPubMed
Turner, R. J. & Finch, J. M. (1990). Immunological malfunctions associated with low selenium vitamin-E diets in lambs. Journal of Comparative Pathology 102, 99109.CrossRefGoogle ScholarPubMed
Turner, R. J. & Finch, J. M. (1991). Selenium and the immune response. Proceedings of the Nutrition Society 50, 275285.CrossRefGoogle ScholarPubMed
Ursini, F., Maiorino, M. & Gregolin, C. (1985). The selenoenzyme phospholipid hydroperoxide glutathione peroxidase. Biochimica et Biophysica Acta 839, 6270.CrossRefGoogle ScholarPubMed
Vanderpas, J. B., Contempre, B., Duale, N. L., Deckx, H., Bebe, N., Longombe, A. O., Thilly, C. H., Diplock, A. T. & Dumont, J. E. (1993). Selenium deficiency mitigates hypothyroxinemia in iodine-deficient subjects. American Journal of Clinical Nutrition 57, S271S275.CrossRefGoogle ScholarPubMed
Vanderpas, J. B., Contempre, B., Duale, N. L., Goossens, W., Bebe, N., Thorpe, R., Ntambue, K., Dumont, J. E., Thilly, C. H. & Diplock, A. T. (1990). Iodine and selenium deficiency associated with cretinism in northern Zaire. American Journal of Clinical Nutrition 52, 10871093.CrossRefGoogle ScholarPubMed
Vendeland, S. C., Beilstein, M. A., Chen, C. L., Jensen, O. N., Barofsky, E. & Whanger, P. D. (1993). Purification and properties of selenoprotein-W from rat muscle. Journal of Biological Chemistry 268, 1710317107.CrossRefGoogle ScholarPubMed
Weitzel, F., Ursini, F. & Wendel, A. (1990). Phospholipid hydroperoxide glutathione peroxidase in various mouse organs during selenium deficiency and repletion. Biochimica et Biophysica Acta 1036, 8894.CrossRefGoogle ScholarPubMed
Weitzel, F. & Wendel, A. (1993). Selenoenzymes regulate the activity of leukocyte 5-lipoxygenase via the peroxide tone. Journal of Biological Chemistry 268, 62886292.CrossRefGoogle ScholarPubMed
Yang, J.-G., Morrison-Plummer, J. & Burk, R. F. (1987). Purification and quantitation of a rat plasma selenoprotein distinct from glutathione peroxidase using monoclonal antibodies. Journal of Biological Chemistry 262, 1337213375.CrossRefGoogle ScholarPubMed
Yoshimura, S., Watanabe, K., Suemizu, H., Onozawa, T., Mizoguchi, J., Tsuda, K., Hatta, H. & Moriuchi, T. (1991). Tissue specific expression of the plasma glutathione peroxidase gene in rat kidney. Journal of Biochemistry 109, 918923.CrossRefGoogle ScholarPubMed