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A specific mixture of short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides induced an anti-allergic Ig profile in infants at risk for allergy

Published online by Cambridge University Press:  12 May 2008

A. J. Nauta ,
S. Arsnalognu ,
G. Boehm ,
G. Moro ,
J. Faber ,
E. Knol ,
B. Ruiter ,
E. van Hoffen ,
L. M'Rabet  and
J. Garssen
A. J. Nauta
Affiliation:
Immunology, Numico-Research BV, Wageningen, The Netherlands
S. Arsnalognu
Affiliation:
Macedonio Melloni Maternity Hospital, Center for Infant Nutrition, Milano, Italy
G. Boehm
Affiliation:
Numico-Research, Friedrichsdorf, Germany
G. Moro
Affiliation:
Macedonio Melloni Maternity Hospital, Center for Infant Nutrition, Milano, Italy
J. Faber
Affiliation:
Immunology, Numico-Research BV, Wageningen, The Netherlands
E. Knol
Affiliation:
Immunology, Numico-Research BV, Wageningen, The Netherlands
B. Ruiter
Affiliation:
Academic Hospital Utrecht, Dermatology, Utrecht, The Netherlands
E. van Hoffen
Affiliation:
Academic Hospital Utrecht, Dermatology, Utrecht, The Netherlands
L. M'Rabet
Affiliation:
Utrecht Institute for Pharmaceutical Sciences, Pharmacology and Pathophysiology, Utrecht, The Netherlands
J. Garssen
Affiliation:
Immunology, Numico-Research BV, Wageningen, The Netherlands Macedonio Melloni Maternity Hospital, Center for Infant Nutrition, Milano, Italy
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Abstract

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Type
1st International Immunonutrition Workshop, Valencia, 3–5 October 2007, Valencia, Spain
Information
Proceedings of the Nutrition Society , Volume 67 , Issue OCE1: 1st International Immunonutrition Workshop, Valencia, 3–5 October 2007, Valencia, Spain , May 2008 , E82
Copyright
Copyright © The Authors 2008

In a prospective study in infants with a family history of atopy a specific prebiotic oligosaccharide mixture (90% short-chain galacto-oligosaccharides and 10% long-chain fructo-oligosaccharides (GOS/FOS; IMMUNOFORTIS) reduced the cumulative incidence of atopic dermatitis at 6 months of age(Reference Moro, Arslanoglu, Stahl, Jelinek, Wahn and Boehm1). In a subgroup of these infants (n 84) it was possible to obtain a blood sample at 6 months of age to analyse the potential effect of these dietary oligosaccharides on the Ig profile.

In this prospective double-blind randomized placebo-controlled study the infants received a hypoallergenic formula with either 8 g GOS/FOS/l or 8 g/ maltodextrin (placebo)/l for 6 months. At 3 months of age children were vaccinated against diphtheria, tetanus and polio (DTP). At 6 months of age total plasma levels of IgE, IgG1, IgG2, IgG3 and IgG4 as well as cow's-milk protein (CMP)- and DTP-specific Ig were measured by ELISA.

Supplementation with GOS/FOS led to a significant reduction in plasma levels of total IgE (P=0.007), IgG2 (P=0.029) and IgG3 (P=0.0343) whereas no significant effect on IgG4 was observed. The plasma levels of CMP-specific IgG1 was significantly decreased (P=0.015) in the GOS/FOS group. The levels of CMP-specific IgE were very low and no effect of GOS/FOS supplementation was observed. CMP-specific IgG4 was not detectable in the samples. No effect of GOS/FOS supplementation on any vaccine-specific antibody isotype levels was found.

Evidently, GOS/FOS supplementation induced an anti-allergic Ig profile in infants at high risk for allergic diseases while the desired specific immune responses were unaffected, indicating the potential role of oral GOS/FOS exposure for primary prevention of allergies.

References

1. Moro, G, Arslanoglu, S, Stahl, B, Jelinek, J, Wahn, U & Boehm, G (2006) Arch Dis Chil 91, 814–819.Google Scholar