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The role of folate in the prevention of neural-tube defects

Published online by Cambridge University Press:  28 February 2007

John Scott
Affiliation:
Department of Biochemistry, Trinity College, Dublin, Republic of Ireland
Peadar Kirke
Affiliation:
Health Research Board, Dublin, Republic of Ireland
Anne Molloy
Affiliation:
Department of Clinical Medicine, Trinity College, Dublin, Republic of Ireland
Leslie Daly
Affiliation:
Department of Public Health Medicine, University College, Dublin, Republic of Ireland
Donald Weir
Affiliation:
Department of Clinical Medicine, Trinity College, Dublin, Republic of Ireland
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Abstract

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Type
‘Newer aspects of micronutrients’
Copyright
Copyright © The Nutrition Society 1994

References

Bailey, L. B. (editor) (1994). Folate requirements and dietary recommendations. In Folate in Health and Disease. New York: Marcel Dekker (In the Press).Google Scholar
Gregory, J. F., Bhandari, S. D., Bailey, L. B., Toth, J. B., Baumgartner, T. G. & Cerda, J. J. (1991). Relative bioavailability of deuterium-labeled monoglutamyl and hexaglutamyl folates in human subjects. American Journal of Clinical Nutrition 53, 736740.CrossRefGoogle ScholarPubMed
Hoffbrand, A. V., Newcombe, B. F. A. & Mollin, D. L. (1966). Method of assay of red cell folate activity and the value of the assays as a test for folate deficiency. Journal of Clinical Pathology 19, 1728.CrossRefGoogle ScholarPubMed
Hoppner, K., Lampi, B. & Smith, D. C. (1977). Data on folacin activity in foods: availability, applications and limitations. Folic Acid, Biochemistry and Physiology in Relation to Human Nutrition Requirements, pp. 6981. Washington DC: National Academy of Sciences.Google Scholar
Kirke, P. N., Molloy, A. M., Daly, L. E., Burke, H., Weir, D. G. & Scott, J. M. (1993). Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects. Quarterly Journal of Medicine 86, 703708.Google ScholarPubMed
Mills, J. L., Rhoads, G. G., Simpson, J. L., Cunningham, G. C., Conlon, M. R., Lassman, M. R., Walden, M. E., Depp, O. R. & Hoffman, H. J. (1989). The absence of a relation between the periconceptional use of vitamins and neural tube defects. New England Journal of Medicine 321, 430435.CrossRefGoogle ScholarPubMed
O'Rahilly, R. & Muller, F. (1994). Neurulation in the normal human embryo. CIBA Foundation Symposium 181, 7089.Google ScholarPubMed
Wald, N. J. (1994). Folic acid and neural tube defects: the current evidence and implications for prevention. CIBA Foundation Symposium 181, 192211.Google ScholarPubMed