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The Relationship between Serum Zinc Levels and Myopia (short-sightedness) in Korean Adolescents

Published online by Cambridge University Press:  24 July 2019

Niamh Burke
Affiliation:
Centre for Eye Research Ireland, GW205-207 Greenway Hub, Environmental Sustainability and Health Institute, Technological University Dublin, Grangegorman, Dublin 7, Ireland;
John S Butler
Affiliation:
Centre for Eye Research Ireland, GW205-207 Greenway Hub, Environmental Sustainability and Health Institute, Technological University Dublin, Grangegorman, Dublin 7, Ireland; School of Mathematical Sciences, College of Sciences & Health, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland;
Ian Flitcroft
Affiliation:
Centre for Eye Research Ireland, GW205-207 Greenway Hub, Environmental Sustainability and Health Institute, Technological University Dublin, Grangegorman, Dublin 7, Ireland; Temple Street Children's University Hospital, Temple Street, Dublin 1, Ireland
James Loughman
Affiliation:
Centre for Eye Research Ireland, GW205-207 Greenway Hub, Environmental Sustainability and Health Institute, Technological University Dublin, Grangegorman, Dublin 7, Ireland; African Vision Research Institute, University of KwaZulu Natal, Durban, South Africa
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Abstract

Type
Abstract
Copyright
Copyright © The Authors 2019 

Myopia, or short-sightedness is one of the leading causes of preventable blindness in the world today. Its prevalence has risen drastically over past decades, with no sign of slowing.(Reference Holden, Fricke and Wilson1) It has been suggested that low serum zinc levels may contribute to the development of myopia,(Reference Fedor, Socha and Urban2, Reference Wang3) and therefore, the aim of this present study is to examine the relationship between serum zinc status and myopia, in adolescents, using a large nationally representative dataset.

Data from 304 adolescents aged 12–19 years, who participated in the Korean National Health and Nutrition Examination Study (KNHANES) from 2010 was used in this study. Multivariate logistic regression analysis was performed to examine the relationship between serum zinc status and myopia after adjustment for potential confounders. Additionally, the association between serum zinc and spherical equivalent refractive error (SER) was examined in the myopia group, through multiple linear regression

Among study participants, 84% were found to be myopic (<=−0.5 dioptres [D]). Although mean serum zinc was higher in the non-myopes [139.3 μg/dL] relative to myopes [138.1 μg/dL], the difference was not statistically significant (p = 0.809). In multiple logistic regression analyses, serum zinc was not significantly associated with myopia, after adjustment for age, gender, residence, body mass index (BMI), family income, and recreational activity. In multiple linear regression, SER was not associated with serum zinc in the myopic group, after adjustment for confounding factors (p = 0.629).

In contrast to previous Asian studies, lower serum zinc is not associated with the presence of myopia in Korean adolescents. However, further well-designed prospective studies should be performed in a large cohort of various ethnic groups.

References

1.Holden, BA, Fricke, TR, Wilson, DA et al. (2016) Global Prevalence of Myopia and High Myopia and Temporal Trends from 2000 through 2050. Ophthalmology 123(5), 10361042.10.1016/j.ophtha.2016.01.006Google Scholar
2.Fedor, M, Socha, K, Urban, B et al. (2017) Serum Concentration of Zinc, Copper, Selenium, Manganese, and Cu/Zn Ratio in Children and Adolescents with Myopia. Biol Trace Elem Res 176(1), 19.10.1007/s12011-016-0805-1Google Scholar
3.Wang, L (2009) Variation analysis of six kinds of common micro- elements contents of blood in myopic primary school students in Dongguan district. Cent Chin Med J 1, 20–2.10.1186/1749-8546-4-20Google Scholar