Hostname: page-component-cd9895bd7-jkksz Total loading time: 0 Render date: 2024-12-22T16:45:05.696Z Has data issue: false hasContentIssue false

Modern fat technology: what is the potential for heart health?

Published online by Cambridge University Press:  07 March 2007

J. E. Upritchard*
Affiliation:
Unilever Health Institute, Unilever Research and Development, PO Box 114, 3130 AC, Vlaardingen, The Netherlands
M. J. Zeelenberg
Affiliation:
Unilever Health Institute, Unilever Research and Development, PO Box 114, 3130 AC, Vlaardingen, The Netherlands
H. Huizinga
Affiliation:
Unilever Health Institute, Unilever Research and Development, PO Box 114, 3130 AC, Vlaardingen, The Netherlands
P. M. Verschuren
Affiliation:
Unilever Health Institute, Unilever Research and Development, PO Box 114, 3130 AC, Vlaardingen, The Netherlands
E. A. Trautwein
Affiliation:
Unilever Health Institute, Unilever Research and Development, PO Box 114, 3130 AC, Vlaardingen, The Netherlands
*
*Corresponding author: Dr Jane Upritchard, fax + 31 104 605 993, [email protected]
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Saturated and trans-fatty acids raise total cholesterol and LDL-cholesterol and are known to increase the risk of CHD, while dietary unsaturated fatty acids play important roles in maintaining cardiovascular health. Replacing saturated fats with unsaturated fats in the diet often involves many complex dietary changes. Modifying the composition of foods high in saturated fat, particularly those foods that are consumed daily, can help individuals to meet the nutritional targets for reducing the risk of CHD. In the 1960s the Dutch medical community approached Unilever about the technical feasibility of producing margarine with a high-PUFA and low-saturated fatty acid composition. Margarine is an emulsion of water in liquid oil that is stabilised by a network of fat crystals. In-depth expertise of fat crystallisation processes allowed Unilever scientists to use a minimum of solid fat (saturated fatty acids) to structure a maximum level of PUFA-rich liquid oil, thus developing the first blood-cholesterol-lowering product, Becel. Over the years the composition of this spread has been modified to reflect new scientific findings and recommendations. The present paper will briefly review the developments in fat technology that have made these improvements possible. Unilever produces spreads that are low in total fat and saturated fat, virtually free of trans-fatty acids and with levels of n-3 and n-6 PUFA that are in line with the latest dietary recommendations for the prevention of CHD. Individuals with the metabolic syndrome have a 2–4-fold increased risk of developing CHD; therefore, these spreads could make a contribution to CHD prevention in this group. In addition, for individuals with the metabolic syndrome the spreads could be further modified to address their unique dyslipidaemia, i.e. elevated blood triacylglycerols and low HDL-cholesterol. Research conducted in the LIPGENE study and other dietary intervention studies will deliver the scientific evidence to justify further modifications in the composition of spreads that are healthy for the heart disease risk factors associated with the metabolic syndrome.

Type
Meeting Report
Copyright
Copyright © The Nutrition Society 2005

References

Ascherio, A, Rimm, EB, Giovannucci, EL, Spiegelman, D, Stampfer, M, Willett, WC (1996) Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States. British Medical Journal 313, 8490 CrossRefGoogle ScholarPubMed
Assmann, G, Schulte, H, von Eckardstein, A, Huang, Y (1996) High-density lipoprotein cholesterol as a predictor of coronary heart disease risk. The PROCAM experience and pathophysiological implications for reverse cholesterol transport. Atherosclerosis 124, S11S20 Suppl. CrossRefGoogle ScholarPubMed
Austin, MA, Hokanson, JE, Edwards, KL (1998) Hypertriglyceridemia as a cardiovascular risk factor. American Journal of Cardiology 81, 7B12B CrossRefGoogle ScholarPubMed
British Heart, Foundation Statistics (2004) CHD 2004: Mortality chapter http://www.heartstats.org/temp/Mortalityspchapter.pdf Google Scholar
Bucher, HC, Hengstler, P, Schindler, C, Meier, G (2002) N-3 polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials. American Journal of Medicine 112, 298304 CrossRefGoogle ScholarPubMed
Burr, ML, Fehily, AM, Gilbert, JF, Rogers, S, Holliday, RM, Sweetnam, PM, Elwood, PC, Deadman, NM (1989) Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). Lancet ii, 757761 CrossRefGoogle Scholar
Clarke, R, Frost, C, Collins, R, Appleby, P, Peto, R (1997) Dietary lipids and blood cholesterol: quantitative meta-analysis of metabolic ward studies. British Medical Journal 314, 112117 CrossRefGoogle ScholarPubMed
Dayton, S, Pearce, ML (1969) Prevention of coronary heart disease and other complications of arteriosclerosis by modified diet. American Journal of Medicine 46, 751762 CrossRefGoogle ScholarPubMed
Dayton, S, Pearce, M, Hashimoto, S (1969) A controlled clinical trial of a diet high in unsaturated fat in preventing complications of atherosclerosis. Circulation 40, S11S63 CrossRefGoogle Scholar
De Lorgeril, M, Salen, P, Martin, JL, Monjaud, I, Delaye, J, Mamelle, N (1999) Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. Circulation 99, 779785 CrossRefGoogle ScholarPubMed
Department of HealthDepartment of Health (2005) Dietary guidelines for Americans. http://www.healthierus.gov/dietaryguidelines/ (accessed February 2005).Google Scholar
Djousse, L, Folsom, AR, Province, MA, Hunt, SC, Ellison, RC (2003) Dietary linolenic acid and carotid atherosclerosis: the National Heart, Lung, and Blood Institute Family Heart Study. American Journal of Clinical Nutrition 77, 819825 CrossRefGoogle ScholarPubMed
Dolecek, TA (1992) Epidemiological evidence of relationships between dietary polyunsaturated fatty acids and mortality in the multiple risk factor intervention trial. Proceedings of the Society for Experimental Biology and Medicine 200, 177182 CrossRefGoogle ScholarPubMed
Eurodiet (2001) Eurodiet core report. Nutrition and diet for healthy lifestyles in Europe: science and policy implications. Public Health Nutrition 4, 265273 CrossRefGoogle Scholar
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Journal of the American Medical Association 285, 24862497 CrossRefGoogle Scholar
Finnegan, YE, Howarth, D, Minihane, AM, Kew, S, Miller, GJ, Calder, PC, Williams, CM (2003) Plant and marine derived (n-3) polyunsaturated fatty acids do not affect blood coagulation and fibrinolytic factors in moderately hyperlipidemic humans. Journal of Nutrition 133, 22102213 CrossRefGoogle Scholar
Food Standards AgencyFood Standards Agency (2004) European Food Standards Agency Opinion. EFSA-Q-2003–022 – London FSA.Google Scholar
Frankel, E (1998) Lipid Oxidation Bridgewater, Somerset PJ Barnes & AssociatesGoogle Scholar
Frantz, ID, Jr, Dawson, EA, Ashman, PL, Gatewood, LC, Bartsch, GE, Kuba, K Brewer, ER (1989) Test of effect of lipid lowering by diet on cardiovascular risk. The Minnesota Coronary Survey. Arteriosclerosis 9, 129135 CrossRefGoogle ScholarPubMed
German Nutrition Society (2000) Referenzwertefür die Nährstoffzuhr (Reference Values for Nutrient Intake Bonn, Germany: DGE-Medien ServiceGoogle Scholar
Goyens, PL, Spilker, ME, Zock, PL, Katan, MB, Mensink, RP (2005) Development of a compartmental model to quantify alpha-linolenic acid conversion after longer-term intake of multiple tracer boluses Journal of Lipid Research Google Scholar
Hegsted, DM, Ausman, LM, Johnson, JA, Dallal, GE (1993) Dietary fat and serum lipids: an evaluation of the experimental data. American Journal of Clinical Nutrition 57, 875883 CrossRefGoogle ScholarPubMed
Hjermann, I, Velve, BK, Holme, I, Leren, P (1981) Effect of diet and smoking intervention on the incidence of coronary heart disease. Report from the Oslo Study Group of a randomised trial in healthy men. Lancet ii, 13031310 CrossRefGoogle Scholar
Hooper, L, Thompson, RL, Harrison, RA, Summerbell, CD, Moore, H, Worthington, HV et al. (2004) Omega 3 fatty acids for prevention and treatment of cardiovascular disease. The Cochrane Database of Systematic Reviews 2004 4 http://www.mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD003177/frame.html Google Scholar
Howell, WH, McNamara, DJ, Tosca, MA, Smith, BT, Gaines, JA (1997) Plasma lipid and lipoprotein responses to dietary fat and cholesterol: a meta-analysis. American Journal of Clinical Nutrition 65, 17471764 CrossRefGoogle ScholarPubMed
Hu, FB, Stampfer, MJ, Manson, JE, Rimm, E, Colditz, GA, Rosner, BA, Hennekens, CH, Willett, WC (1997) Dietary fat intake and the risk of coronary heart disease in women. New England Journal of Medicine 337, 14911499 CrossRefGoogle ScholarPubMed
Hulshof, KFAM, van Erp-Baart, MA, Anttolainen, M, Becker, W, Church, SM, Couet, C et al. . (1999) Intake of fatty acids in Western Europe with emphasis on trans fatty acids: The TRANSFAIR study. European Journal of Clinical Nutrition 53, 143157 CrossRefGoogle ScholarPubMed
Institute of, Nutritional Sciences (2003) Austrian Nutrition Report. Vienna, Austria: Federal Ministry of Health and Women.Google Scholar
Jousilahti, P, Vartiainen, E, Pekkanen, J, Tuomilehto, J, Sundvall, J, Puska, P (1998) Serum cholesterol distribution and coronary heart disease risk: observations and predictions among middle-aged population in eastern Finland. Circulation 97, 10871094 CrossRefGoogle ScholarPubMed
Kannel, WB, Castelli, WP, Gordon, T (1979) Cholesterol in the prediction of atherosclerotic disease. New perspectives based on the Framingham study. Annals of Internal Medicine 90, 8591 CrossRefGoogle ScholarPubMed
Keys, A (1965) Effects of different dietary fats on plasma lipid levels. Lancet i, 318319 CrossRefGoogle Scholar
Kris-Etherton, PM, Harris, WS, Appel, LJ (2003) Omega-3 fatty acids and cardiovascular disease: new recommendations from the American Heart Association. Arteriosclerosis, Thrombosis, and Vascular Biology 23, 151152 CrossRefGoogle ScholarPubMed
Law, MR, Wald, NJ, Thompson, SG (1994) By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease. British Medical Journal 308, 367373 CrossRefGoogle ScholarPubMed
Leren, P (1970) The Oslo diet-heart study. Eleven-year report. Circulation 42, 935942 CrossRefGoogle ScholarPubMed
Marchioli, R, Barzi, F, Bomba, E, Chieffo, C, Di, Gregorio, D, Di, Mascio, R et al. . (2002) Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione. Circulation 105, 18971903 CrossRefGoogle ScholarPubMed
Martin, MJ, Hulley, SB, Browner, WS, Kuller, LH, Wentworth, D (1986) Serum cholesterol, blood pressure, and mortality: implications from a cohort of 361, 662 men. Lancet ii, 933936 CrossRefGoogle Scholar
Mensink, RP, Zock, PL, Kester, AD, Katan, MB (2003) Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. American Journal of Clinical Nutrition 77, 11461155 CrossRefGoogle ScholarPubMed
Miettinen, M, Turpeinen, O, Karvonen, MJ, Pekkarinen, M, Paavilainen, E, Elosuo, R (1983) Dietary prevention of coronary heart disease in women: the Finnish mental hospital study. International Journal of Epidemiology 12, 1725 CrossRefGoogle ScholarPubMed
National, Council, on, Nutrition (1997) Voedingesaanbe Verlingen voor België (Dietary Recommendation for Belgium). Ministry of Social Affairs, Public Health and Environment Publication no. D/1996/7795/12 Brussels, Belgium Ministry of Social Affairs, Public Health and EnvironmentGoogle Scholar
National Health and, Medical Research Council (2003) Dietary Guidelines for Australian Adults Canberra, ACT National Health and Medical Research CouncilGoogle Scholar
National Institutes, of Health (1998) Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults Bethesda, MA NIH, National Heart, Lung and Blood InstituteGoogle Scholar
National Nutrition Council (1999) Finnish Nutritional Recommendations Helsinki, Finland Ministry of Agriculture and ForestryGoogle Scholar
Nishida, C, Uauy, R, Kumanyika, S, Shetty, P (2004) The Joint WHO/FAO Expert Consultation on diet, nutrition and the prevention of chronic diseases: process, product and policy implications. Public Health Nutrition 7, 245250 CrossRefGoogle ScholarPubMed
Pedersen, TR, Olsson, AG, Faergeman, O, Kjekshus, J, Wedel, H, Berg, K et al. . (1998) Lipoprotein changes and reduction in the incidence of major coronary heart disease events in the Scandinavian Simvastatin Survival Study (4S). Circulation 97, 14531460 CrossRefGoogle ScholarPubMed
Pietinen, P, Ascherio, A, Korhonen, P, Hartman, AM, Willett, WC, Albanes, D, Virtamo, J (1997) Intake of fatty acids and risk of coronary heart disease in a cohort of Finnish men. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. American Journal of Epidemiology 145, 876887 CrossRefGoogle Scholar
Sandström, B, Lyhne, N, Petersen, JI, Aro, A, Thorsdóttir, I, Becker, W (1996) Nordic nutrition recommendations. Scandinavian Journal of Nutrition 40, 161165 Google Scholar
Singh, RB, Niaz, MA, Sharma, JP, Kumar, R, Rastogi, V, Moshiri, M (1997) Randomized, double-blind, placebo-controlled trial of fish oil and mustard oil in patients with suspected acute myocardial infarction: the Indian experiment of infarct survival-4. Cardiovascular Drugs and Therapy 11, 485491 CrossRefGoogle ScholarPubMed
Turpeinen, O (1979) Effect of cholesterol-lowering diet on mortality from coronary heart disease and other causes. Circulation 59, 17 CrossRefGoogle ScholarPubMed
Turpeinen, O, Karvonen, MJ, Pekkarinen, M, Miettinen, M, Elosuo, R, Paavilainen, E (1979) Dietary prevention of coronary heart disease: the Finnish Mental Hospital Study. International Journal of Epidemiology 8, 99118 CrossRefGoogle ScholarPubMed
US Department of AgricultureUS Department of Agriculture (2002) USDA National Nutrient Database for Standard Reference, release 15. http://www.nal.usda.gov/fnic/foodcomp (accessed January 2005).Google Scholar
Willett, WC, Stampfer, MJ, Manson, JE, Colditz, GA, Speizer, FE, Rosner, BA, Sampson, LA, Hennekens, CH (1993) Intakes of trans fatty acids and risk of coronary heart disease among women. Lancet 341, 581585 CrossRefGoogle ScholarPubMed
World Health OrganizationWorld Health Organization (2003) Diet, Nutrition and the Prevention of Chronic Diseases. Joint WHO/FAO Expert Consultation. WHO Technical Report Series no. 916. Geneva: WHO.Google Scholar
Yu-Poth, S, Zhao, G, Etherton, T, Naglak, M, Jonnalagadda, S, Kris-Etherton, PM (1999) Effects of the National Cholesterol Education Program's Step I and Step II dietary intervention programs on cardiovascular disease risk factors: a meta-analysis. American Journal of Clinical Nutrition 69, 632646 CrossRefGoogle ScholarPubMed