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Influence of triacylglycerol structure of stearic acid-rich fats on postprandial lipaemia

Published online by Cambridge University Press:  07 March 2007

Sarah E. E. Berry*
Affiliation:
Nutrition Food and Health Research Centre, King's College London, Franklin Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK
Thomas A. B. Sanders
Affiliation:
Nutrition Food and Health Research Centre, King's College London, Franklin Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK
*
*Corresponding author: Dr Sarah Berry, fax +44 20 7848 4185, email [email protected]
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Abstract

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Exaggerated postprandial lipaemia may increase the risk of CHD by contributing to both thrombotic and atherogenic processes. Previous research has focused on the quantity and composition of dietary fat, whereas the effect of triacylglycerol (TAG) structure on postprandial lipaemia and clotting factor VII activity has received little attention. TAG with similar fatty acid composition may have different biochemical and physical properties that are dependent on their TAG structure, and these differences may affect lipid metabolism. Recent findings suggest that differences in the physical properties of stearic acid-rich fats are associated with differences in postprandial lipaemia, and may play an important role in determining their rates of digestion and absorption.

Type
Postgraduate Symposium
Copyright
Copyright © The Nutrition Society 2005

References

Berry, SE & Sanders, TA (2003a) Physical properties of stearic-acid-rich triacylglycerols modulate effects on postprandial lipaemia. Proceedings of the Nutrition Society 62, 47AGoogle Scholar
Berry, SE & Sanders, TA (2003b) Postprandial lipaemia induced by cocoabutter compared with an inter-esterified blend of totally hydrogenated and unhydrogenated high oleic sunflower oil. Proceedings of the Nutrition Society 62, 41AGoogle Scholar
Bonanome, A & Grundy, SM (1988) Effect of dietary stearic acid on plasma cholesterol and lipoprotein levels. New England Journal of Medicine 318, 12441248.CrossRefGoogle ScholarPubMed
Bracco, U (1994) Effect of triglyceride structure on fat absorption. American Journal of Clinical Nutrition 60, 1002S1009S.CrossRefGoogle ScholarPubMed
Carnielli, VP, Luijendijk, IH, van Goudoever, JB, Sulkers, EJ, Boerlage, AA, Degenhart, HJ & Sauer, PJ (1995) Feeding premature newborn infants palmitic acid in amounts and stereoisomeric position similar to that of human milk: effects on fat and mineral balance. American Journal of Clinical Nutrition 61, 10371042.CrossRefGoogle ScholarPubMed
Chen, YD, Skowronski, R, Coulston, AM, Pietarinen, J, Hollenbeck, CB & Reaven, GM (1992) Effect of acute variations in dietary fat and carbohydrate intake on retinyl ester content of intestinally derived lipoproteins. Journal of Clinical Endocrinology and Metabolism 74, 2832.Google ScholarPubMed
Cheng, AL, Morehouse, MG & Deuel, HJ (1949) The effect of the level of dietary calcium and magnesium on the digestibility of fatty acids, simple triglycerides, and some natural and hydrogenated fats. Journal of Nutrition 37, 237CrossRefGoogle ScholarPubMed
Cohen, JC, Noakes, TD & Benade, AJ (1988) Serum triglyceride responses to fatty meals: effects of meal fat content. American Journal of Clinical Nutrition 47, 825827.CrossRefGoogle ScholarPubMed
Connor, WE, Witiak, DT, Stone, DB & Armstrong, ML (1969) Cholesterol balance and fecal neutral steroid and bile acid excretion in normal men fed dietary fats of different fatty acid composition. Journal of Clinical Investigation 48, 13631375.CrossRefGoogle ScholarPubMed
Decker, EA (1996) The role of stereospecific saturated fatty acid positions on lipid nutrition. Nutrition Reviews 54, 108110.CrossRefGoogle ScholarPubMed
Denke, MA & Grundy, SM (1991) Effects of fats high in stearic acid on lipid and lipoprotein concentrations in men. American Journal of Clinical Nutrition 54, 10361040.CrossRefGoogle ScholarPubMed
Dougherty, RM, Allman, MA & Iacono, JM (1995) Effects of diets containing high or low amounts of stearic acid on plasma lipoprotein fractions and fecal fatty acid excretion of men. American Journal of Clinical Nutrition 61, 11201128.CrossRefGoogle ScholarPubMed
Dubois, C, Beaumier, G, Juhel, C, Armand, M, Portugal, H, Pauli, AM, Borel, P, Latge, C & Lairon, D (1998) Effects of graded amounts (0–50 g) of dietary fat on postprandial lipemia and lipoproteins in normolipidemic adults. American Journal of Clinical Nutrition 67, 3138.CrossRefGoogle ScholarPubMed
Emken, EA (1992) What is the metabolic fate of dietary long-chain fatty acids (especially stearic acid) in normal physiological states, and how might this relate to thrombosis. American Journal of Clinical Nutrition 56, 798S Suppl.CrossRefGoogle ScholarPubMed
Emken, EA, Adlof, RO, Rohwedder, WK & Gulley, RM (1993) Influence of linoleic acid on desaturation and uptake of deuterium-labeled palmitic and stearic acids in humans. Biochimica et Biophysica Acta 1170, 173181.CrossRefGoogle ScholarPubMed
Finley, JW, Klemann, LP, Leveille, GA, Otterburn, MS & Walchak, CG (1994) Caloric availability of salatrim in rats and humans. Journal of Agricultural and Food Chemistry 42, 495499.CrossRefGoogle Scholar
Gianturco, SH & Bradley, WA (1999) Pathophysiology of triglyceride-rich lipoproteins in atherothrombosis: cellular aspects. Clinical Cardiology 22, Suppl., II7II14.CrossRefGoogle ScholarPubMed
Griffin, BA (1999) Lipoprotein atherogenicity: an overview of current mechanisms. Proceedings of the Nutrition Society 58, 163169.CrossRefGoogle ScholarPubMed
Hegsted, DM, McGandy, RB, Myers, ML & Stare, FJ (1965) Quantitative effects of dietary fat on serum cholesterol in man. American Journal of Clinical Nutrition 17, 281295.CrossRefGoogle ScholarPubMed
Hodge, J, Li, D, Redgrave, TG & Sinclair, AJ (1999) The metabolism of native and randomized butterfat chylomicrons in the rat is similar. Lipids 34, 579582.CrossRefGoogle Scholar
Innis, SM, Dyer, R & Nelson, CM (1994) Evidence that palmitic acid is absorbed as sn-2 monoacylglycerol from human milk by breast-fed infants. Lipids 29, 541545.CrossRefGoogle ScholarPubMed
Jackson, KG, Robertson, MD, Fielding, BA, Frayn, KN & Williams, CM (2002) Olive oil increases the number of triacylglycerol-rich chylomicron particles compared with other oils: an effect retained when a second standard meal is fed. American Journal of Clinical Nutrition 76, 942949.CrossRefGoogle Scholar
Jung, HR, Turner, SM, Neese, RA, Young, SG & Hellerstein, MK (1999) Metabolic adaptations to dietary fat malabsorption in chylomicron-deficient mice. Biochemical Journal 343, 473478.CrossRefGoogle ScholarPubMed
Keys, A, Anderson, JT & Grande, F (1965) Serum cholesterol response to changes in the diet. IV. Particular saturated fatty acids in the diet. Metabolism: Clinical and Experimental 14, 776786.CrossRefGoogle ScholarPubMed
Kris-Etherton, PM, Derr, J, Mitchell, DC, Mustad, VA, Russell, ME, McDonnell, ET, Salabsky, D & Pearson, TA (1993) The role of fatty acid saturation on plasma lipids, lipoproteins, and apolipoproteins: I. Effects of whole food diets high in cocoa butter, olive oil, soybean oil, dairy butter, and milk chocolate on the plasma lipids of young men. Metabolism 42, 121129.CrossRefGoogle ScholarPubMed
Kritchevsky, D (1995) Fatty acids, triglyceride structure, and lipid metabolism. Journal of Nutritional Biochemistry 6, 172178.CrossRefGoogle Scholar
Langworthy, CF (1923) The digestibilty of fats. Industrial and Engineering Chemistry 15, 276278.CrossRefGoogle Scholar
McFarlane, I (1994) Instrumentation. In Industrial Chocolate Manufacture and Use, 2nd ed., p. 299 [Beckett, ST, editors] London: Blackie Academic & ProfessionalGoogle Scholar
Mattil, KF & Higgins, JW (1945) The relationship of glyceride structure in fat digestibility. Synthetic glycerides of 18:0 and 18:1 acids. Journal of Nutrition 29, 225260.CrossRefGoogle Scholar
Mattson, FH (1959) The absorbability of stearic acid when fed as a simple or mixed triglyceride. Journal of Nutrition 69, 338342.CrossRefGoogle Scholar
Mattson, FH, Nolen, GA & Webb, MR (1979) The absorbability by rats of various triglycerides of stearic and oleic acid and the effect of dietary calcium and magnesium. Journal of Nutrition 109, 16821687.CrossRefGoogle ScholarPubMed
Mitchell, DC, McMahon, KE, Shively, CA, Apgar, JL, Kris-Etherton, PM (1989) Digestibility of cocoa butter and corn oil in human subjects: a preliminary study. American Journal of Clinical Nutrition 50, 983986.CrossRefGoogle ScholarPubMed
Mortimer, BC, Holthouse, DJ, Martins, IJ, Stick, RV & Redgrave, TG (1994) Effects of triacylglycerol-saturated acyl chains on the clearance of chylomicron-like emulsions from the plasma of the rat. Biochimica et Biophysica Acta 1211, 171180.CrossRefGoogle ScholarPubMed
Mortimer, BC, Kenrick, MA, Holthouse, DJ, Stick, RV & Redgrave, TG (1992) Plasma clearance of model lipoproteins containing saturated and polyunsaturated monoacylglycerols injected intravenously in the rat. Biochimica et Biophysica Acta 1127, 6773.CrossRefGoogle ScholarPubMed
Mortimer, BC, Simmonds, WJ, Joll, CA, Stick, RV & Redgrave, TG (1988) Regulation of the metabolism of lipid emulsion model lipoproteins by a saturated acyl chain at the 2-position of triacylglycerol. Journal of Lipid Research 29, 713720.CrossRefGoogle Scholar
Nilsson-Ehle, P, Egelrud, T, Belfrage, P, Olivecrona, T & Borgstrom, B (1973) Positional specificity of purified milk lipoprotein lipase. Journal of Biological Chemistry 248, 67346737.CrossRefGoogle ScholarPubMed
Oakley, FR, Sanders, TA & Miller, GJ (1998) Postprandial effects of an oleic acid-rich oil compared with butter on clotting factor VII and fibrinolysis in healthy men. American Journal of Clinical Nutrition 68, 12021207.CrossRefGoogle ScholarPubMed
Ong, PJ, Dean, TS, Della Hayward, CS, Monica, PL, Sanders, TA, Collins, P (1999) Effect of fat and carbohydrate consumption on endothelial function. Lancet 354, 2134CrossRefGoogle ScholarPubMed
Patsch, JR, Miesenbock, G, Hopferwieser, T, Muhlberger, V, Knapp, E, Dunn, JK, Gotto, AM Jr, Patsch, W (1992) Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state. Arteriosclerosis and Thrombosis 12, 13361345.CrossRefGoogle ScholarPubMed
Pufal, DA, Quinlan, PT & Salter, AM (1995) Effect of dietary triacylglycerol structure on lipoprotein metabolism: a comparison of the effects of dioleoylpalmitoylglycerol in which palmitate is esterified to the 2- or 1(3)-position of the glycerol. Biochimica et Biophysica Acta 1258, 4148.CrossRefGoogle ScholarPubMed
Redgrave, TG, Kodali, DR & Small, DM (1988) The effect of triacyl-sn-glycerol structure on the metabolism of chylomicrons and triacylglycerol-rich emulsions in the rat. Journal of Biological Chemistry 263, 51185123.CrossRefGoogle Scholar
Roche, HM, Zampelas, A, Jackson, KG, Williams, CM & Gibney, MJ (1998) The effect of test meal monounsaturated fatty acid:saturated fatty acid ratio on postprandial lipid metabolism. British Journal of Nutrition 79, 419424.CrossRefGoogle ScholarPubMed
Sanders, TA (2003) Dietary fat and postprandial lipids. Current Atherosclerosis Reports 5, 445451.CrossRefGoogle ScholarPubMed
Sanders, TA, Berry, SE & Miller, GJ (2003a) Influence of triacylglycerol structure on the postprandial response of factor VII to stearic acid-rich fats. American Journal of Clinical Nutrition 77, 777782.CrossRefGoogle ScholarPubMed
Sanders, TA, de Grassi, T, Miller, GJ & Morrissey, JH (2000) Influence of fatty acid chain length and cis/trans isomerization on postprandial lipemia and factor VII in healthy subjects (postprandial lipids and factor VII). Atherosclerosis 149, 413420.CrossRefGoogle ScholarPubMed
Sanders, TA, Oakley, FR, Cooper, JA & Miller, GJ (2001) Influence of a stearic acid-rich structured triacylglycerol on postprandial lipemia, factor VII concentrations, and fibrinolytic activity in healthy subjects. American Journal of Clinical Nutrition 73, 715721.CrossRefGoogle ScholarPubMed
Sanders, TA, Oakley, FR, Crook, D, Cooper, JA & Miller, GJ (2003b) High intakes of trans monounsaturated fatty acids taken for 2 weeks do not influence procoagulant and fibrinolytic risk markers for CHD in young healthy men. British Journal of Nutrition 89, 767776.CrossRefGoogle Scholar
Sanders, TA, Oakley, FR, Miller, GJ, Mitropoulos, KA, Crook, D & Oliver, MF (1997) Influence of n -6 versus n -3 polyunsaturated fatty acids in diets low in saturated fatty acids on plasma lipoproteins and hemostatic factors. Arteriosclerosis, Thrombosis and Vascular Biology 17, 34493460.CrossRefGoogle Scholar
Schneider, CL, Cowles, RL, Stuefer-Powell, CL & Carr, TP (2000) Dietary stearic acid reduces cholesterol absorption and increases endogenous cholesterol excretion in hamsters fed cereal-based diets. Journal of Nutrition 130, 12321238.CrossRefGoogle ScholarPubMed
Shahkhalili, Y, Duruz, E & Acheson, K (2000) Digestibility of cocoa butter from chocolate in humans: a comparison with corn-oil. European Journal of Clinical Nutrition 54, 120125.CrossRefGoogle ScholarPubMed
Small, DM (1991) The effects of glyceride structure on absorption and metabolism. Annual Review of Nutrition 11, 413434.CrossRefGoogle ScholarPubMed
Snook, JT, Park, S, Williams, G, Tsai, Y-H & Lee, N (1999) Effect of synthetic triglycerides of myristic, palmitic, and stearic acid on serum lipoprotein metabolism. European Journal of Clinical Nutrition 53, 597605.CrossRefGoogle ScholarPubMed
Summers, LK, Fielding, BA, Herd, SL, Ilic, V, Clark, ML, Quinlan, PT & Frayn, KN (1999) Use of structured triacylglycerols containing predominantly stearic and oleic acids to probe early events in metabolic processing of dietary fat. Journal of Lipid Research 40, 18901898.CrossRefGoogle ScholarPubMed
Talbot, G (1994) Instrumentation. In Industrial Chocolate Manufacture and Use, 2nd ed., 243246 [Beckett, ST, editors] London: Blackie Academic & ProfessionalGoogle Scholar
Tholstrup, T, Sandstrom, B, Bysted, A & Holmer, G (2001) Effect of 6 dietary fatty acids on the postprandial lipid profile, plasma fatty acids, lipoprotein lipase, and cholesterol ester transfer activities in healthy young men. American Journal of Clinical Nutrition 73, 198208.CrossRefGoogle ScholarPubMed
Timms, RE (1984) Phase behaviour of fats and their mixtures. Progress in Lipid Research 23, 138.CrossRefGoogle ScholarPubMed
Tomarelli, RM, Meyer, BJ, Weaber, JR & Bernhart, FW (1968) Effect of positional distribution on the absorption of the fatty acids of human milk and infant formulas. Journal of Nutrition 95, 583590.CrossRefGoogle ScholarPubMed
Weintraub, MS, Zechner, R, Brown, A, Eisenberg, S & Breslow, JL (1988) Dietary polyunsaturated fats of the W-6 and W-3 series reduce postprandial lipoprotein levels. Chronic and acute effects of fat saturation on postprandial lipoprotein metabolism. Journal of Clinical Investigation 82, 18841893.CrossRefGoogle ScholarPubMed
Yang, LY & Kuksis, A (1991) Apparent convergence (at 2-monoacylglycerol level) of phosphatidic acid and 2-monoacylglycerol pathways of synthesis of chylomicron triacylglycerols. Journal of Lipid Research 32, 11731186.CrossRefGoogle ScholarPubMed
Yli-Jokipii, K, Kallio, H, Schwab, U, Mykkanen, H, Kurvinen, JP, Savolainen, MJ & Tahvonen, R (2001) Effects of palm oil and transesterified palm oil on chylomicron and VLDL triacylglycerol structures and postprandial lipid response. Journal of Lipid Research 42, 16181625.CrossRefGoogle ScholarPubMed
Yli-Jokipii, KM, Schwab, US, Tahvonen, RL, Kurvinen, JP, Mykkanen, HM & Kallio, HP (2002) Triacylglycerol molecular weight and to a lesser extent, fatty acid positional distribution, affect chylomicron triacylglycerol composition in women. Journal of Nutrition 132, 924929.CrossRefGoogle ScholarPubMed
Zampelas, A, Murphy, M, Morgan, LM & Williams, CM (1994a) Postprandial lipoprotein lipase, insulin and gastric inhibitory polypeptide responses to test meals of different fatty acid composition: comparison of saturated, n -6 and n -3 polyunsaturated fatty acids. European Journal of Clinical Nutrition 48, 849858.Google ScholarPubMed
Zampelas, A, Williams, CM, Morgan, LM, Wright, J & Quinlan, PT (1994b) The effect of triacylglycerol fatty acid positional distribution on postprandial plasma metabolite and hormone responses in normal adult men. British Journal of Nutrition 71, 401410.CrossRefGoogle ScholarPubMed
Zilversmit, DB (1979) Atherogenesis: a postprandial phenomenon. Circulation 60, 473485.CrossRefGoogle ScholarPubMed