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Discussion: Aims and Achievements of The Reductionist Approach in Biochemistry/Molecular Biology/Cell Biology: A Response to Kincaid

Published online by Cambridge University Press:  01 April 2022

Joseph D. Robinson*
Affiliation:
Department of Pharmacology, SUNY Health Science Center at Syracuse

Abstract

Kincaid argues that molecular biology provides little support for the reductionist program, that biochemistry does not reveal common mechanisms, indeed that biochemical theory obstructs discovery. These assertions clash with biologists' stated advocacy of reductionist programs and their claims about the consequent unity of experimental biology. This striking disagreement goes beyond differences in meaning granted to the terms. More significant is Kincaid's misunderstanding of what biochemists do, for a closer look at scientific practice— and one of Kincaid's examples—reveals substantial progress toward explaining biological function with biochemical models. With the molecular detail emerge unifying generalizations as well as further aspects of the functional processes.

Type
Research Article
Copyright
Copyright © 1992 by the Philosophy of Science Association

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Footnotes

I thank an anonymous referee for valuable suggestions on restructuring and reorganizing the arguments.

Send reprint requests to the author, Department of Pharmacology, SUNY Health Science Center at Syracuse, Syracuse, New York 13210, USA.

References

Alberts, B.; Bray, D.; Lewis, J.; Raff, M.; Roberts, K.; and Watson, J. (1983), Molecular Biology of the Cell. New York: Garland.Google Scholar
Darnell, J.; Lodish, H.; and Baltimore, D. (1990), Molecular Cell Biology. 2d ed. New York: Freeman.Google Scholar
Gilbert, W. (1991), “Towards a Paradigm Shift in Biology”, Nature 349: 99.CrossRefGoogle ScholarPubMed
Gilman, A. G.; Rall, T. W.; Nies, A. S.; and Taylor, P. (1990), The Pharmacological Basis of Therapeutics. 8th ed. New York: Pergamon Press.Google Scholar
Karnovsky, M. L. (1991), “Book Review: Molecular Cell Biology”, New England Journal of Medicine 324: 6465.CrossRefGoogle Scholar
Kincaid, H. (1990), “Molecular Biology and the Unity of Science”, Philosophy of Science 57: 575593.CrossRefGoogle Scholar
Mayr, E. (1982), The Growth of Biological Thought: Diversity, Evolution, and Inheritance. Cambridge, MA: Harvard University Press.Google Scholar
Morimoto, B. H. and Koshland, D. E. Jr. (1991), “Short-Term and Long-Term Memory in Single Cells”, FASEB Journal 5: 20612067.CrossRefGoogle ScholarPubMed
Nagel, E. (1979), The Structure of Science. Indianapolis: Hacker.Google Scholar
Robinson, J. D. (1986), “Reduction, Explanation, and the Quests of Biological Research”, Philosophy of Science 53: 333353.CrossRefGoogle Scholar
Sokoloff, P.; Giros, B.; Martres, M. P.; Bouthenet, M. L.; and Schwartz, J. C. (1990), “Molecular Cloning and Characterization of a Novel Dopamine Receptor (D3) as a Target for Neuroleptics”, Nature 347: 146151.CrossRefGoogle ScholarPubMed
Stryer, L. (1988), Biochemistry. 3rd ed. New York: Freeman.Google Scholar
Weinberg, S. (1987), “Newtonianism, Reductionism and the Art of Congressional Testimony”, Nature 330: 433437.CrossRefGoogle Scholar
White, A.; Handler, P.; Smith, E. L.; and Stetten, D. (1954), Principles of Biochemistry. New York: McGraw-Hill.Google Scholar
Wimsatt, W. C. (1976), “Reductive Explanation: A Functional Account”, Boston Studies in the Philosophy of Science, vol. 32. Dordrecht: Reidel, pp. 671710.Google Scholar