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The Wellcome Trust Lecture: Genes for antigens of Plasmodium falciparum

Published online by Cambridge University Press:  23 August 2011

D. J. Kemp ,
R. L. Coppel ,
H. D. Stahl ,
A. E. Bianco ,
L. M. Corcoran ,
P. McIntyre ,
C. J. Langford ,
J. M. Favaloro ,
P. E. Crewther  and
G. V. Brown
...Show all authors
D. J. Kemp
Affiliation:
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
R. L. Coppel
Affiliation:
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
H. D. Stahl
Affiliation:
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
A. E. Bianco
Affiliation:
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
L. M. Corcoran
Affiliation:
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
P. McIntyre
Affiliation:
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
C. J. Langford
Affiliation:
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
J. M. Favaloro
Affiliation:
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
P. E. Crewther
Affiliation:
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
G. V. Brown
Affiliation:
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
G. F. Mitchell
Affiliation:
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
J. G. Culvenor
Affiliation:
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
R. F. Anders
Affiliation:
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
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Extract

Sporozoites of P. falciparum and other Plasmodia appear to be fairly simple antigenically, in that there is a dominant antigen, the circumsporozoite (CS) protein that forms the sporozoite surface coat (Potocnjak, Yoshida, Nussenzweig & Nussensweig, 1980; Santoro et al. 1983). Consequently, the CS protein and the gene encoding it have now been studied in considerable detail (Ellis et al. 1983; Godson et al. 1983; Ozaki et al. 1983; Dame et al. 1984; Enea et al. 1984). In contrast to sporozoites, the asexual blood stages of P. falciparum are antigenically complex. Two-dimensional gel analyses of immunoprecipitated, biosynthetically labelled antigens indicate that repeated infection with P. falciparum results in the synthesis of antibodies against a large number of distinct antigens (Perrin & Dayal, 1982; Brown et al. 1981, 1983). In further contrast to the sporozoite, the asexual blood stages of different P. falciparum isolates exhibit a high degree of antigenic heterogeneity (Brown et al. 1983; Hall et al. 1983; McBride, Walliker & Morgan, 1982). Much of this antigenic diversity is no doubt due to allelic differences but clonal populations of parasites may also have the capacity to undergo antigenic variation (Hommel, David & Oligino, 1983).

Type
Research Article
Information
Parasitology , Volume 92 , supplement S1: Symposia of the British Society for Parasitology Volume 23 Parasites and molecular biology: applications of new techniques , January 1986 , pp. S83 - S108
Copyright
Copyright © Cambridge University Press 1986

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