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Vaccination of young lambs by means of a protein fraction extracted from adult Haemonchus contortus

Published online by Cambridge University Press:  06 April 2009

E. A. Munn ,
C. A. Greenwood  and
W. J. Coadwell
E. A. Munn
Affiliation:
Agricultural and Food Research Council, Institute of Animal Physiology, Babraham, Cambridge CB2 4AT
C. A. Greenwood
Affiliation:
Agricultural and Food Research Council, Institute of Animal Physiology, Babraham, Cambridge CB2 4AT
W. J. Coadwell
Affiliation:
Agricultural and Food Research Council, Institute of Animal Physiology, Babraham, Cambridge CB2 4AT
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Summary

Lambs aged 48–150 days which had been injected with extracts enriched in a functional antigen (contortin) obtained from adult Haemonchus contortus developed specific circulating antibodies and were less susceptible to haemonchosis when challenged 1 month later with a single dose of 20000–25000 infective 3rd-stage larvae. Sera from 18 out of a total of 19 lambs injected with the extract contained precipitating antibodies to 2–5 components of the extract. None of these lambs died. The one extract-injected lamb which did not develop antibodies and 9 of the 13 lambs used as controls died of haemonchosis. The average weight of worms recovered was 1·45 g from the immune lambs and 5·72 g from the non-immune lambs.

Type
Research Article
Information
Parasitology , Volume 94 , Issue 2 , April 1987 , pp. 385 - 397
Copyright
Copyright © Cambridge University Press 1987

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