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Vaccination of langur monkeys (Presbytis entellus) against Leishmania donovani with autoclaved L. major plus BCG

Published online by Cambridge University Press:  01 March 1998

ANURADHA DUBE ,
P. SHARMA ,
J. K. SRIVASTAVA ,
A. MISRA ,
S. NAIK  and
J. C. KATIYAR
ANURADHA DUBE
Affiliation:
Division of Parasitology, Central Drug Research Institute, PO Box 173, Lucknow – 226001, India
P. SHARMA
Affiliation:
Division of Parasitology, Central Drug Research Institute, PO Box 173, Lucknow – 226001, India
J. K. SRIVASTAVA
Affiliation:
Division of Parasitology, Central Drug Research Institute, PO Box 173, Lucknow – 226001, India
A. MISRA
Affiliation:
Division of Parasitology, Central Drug Research Institute, PO Box 173, Lucknow – 226001, India
S. NAIK
Affiliation:
Department of Immunology, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow – 226014, India
J. C. KATIYAR
Affiliation:
Division of Parasitology, Central Drug Research Institute, PO Box 173, Lucknow – 226001, India
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Abstract

The protective potential of killed Leishmania major (ALM) along with BCG was evaluated against L. donovani in Indian langur monkeys in single and triple dose schedules. A delayed protection was observed in monkeys after a single dose schedule of ALM (3 mg)+BCG (3 mg) given intradermally 2 months before intravenous challenge with L. donovani. Triple dose schedule each of 1 mg ALM+1 mg BCG was more effective. The status remained unchanged until the end of the experiment (approximately 8 months). The study indicates that a combination of ALM+BCG may be a good candidate vaccine for exploiting against human Kala-azar.

Keywords

Leishmania majorBCGL. donovaniIndian langur monkeyscross-protectionvaccination
Type
Research Article
Information
Parasitology , Volume 116 , Issue 3 , March 1998 , pp. 219 - 221
Copyright
1998 Cambridge University Press

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