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Uptake of [14C]oxamniquine by Schistosoma mansoni

Published online by Cambridge University Press:  06 April 2009

N. M. Woolhouse  and
B. Kaye
N. M. Woolhouse
Affiliation:
Department of Drug Metabolism, Pfizer Central Research, Sandwich, Kent CT13 9NJ
B. Kaye
Affiliation:
Department of Drug Metabolism, Pfizer Central Research, Sandwich, Kent CT13 9NJ
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Extract

The uptake and retention of drug-related material by Schistosoma mansoni was studied in the mouse host following a single oral or intramuscular does (50 mg/kg) of [14C]oxamniquine. Male worms took up more labelled material than did female worms but the amount in each particular sex of worm was found to be similar after both routes of administration. Exposure of worms was therefore independent of the route of administration. Six days after drug administration, at the time of an hepatic shift, significantly more drug-related material* was present in male worms than in female worms. Examination of worms recovered from mice 4 h after treatment showed that metabolites of oxamniquine constituted 70–90% of the drug-related material present in the worms. Both sexes of worms were able to take up matebolites of oxamniquine win vitro.

Type
Research Article
Information
Parasitology , Volume 75 , Issue 1 , August 1977 , pp. 111 - 118
Copyright
Copyright © Cambridge University Press 1977

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