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Trypanosoma cruzi–Trypanosoma rangeli co-infection ameliorates negative effects of single trypanosome infections in experimentally infected Rhodnius prolixus

Published online by Cambridge University Press:  13 May 2016

JENNIFER K. PETERSON ,
ANDREA L. GRAHAM ,
RYAN J. ELLIOTT ,
ANDREW P. DOBSON  and
OMAR TRIANA CHÁVEZ
JENNIFER K. PETERSON*
Affiliation:
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA
ANDREA L. GRAHAM
Affiliation:
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA
RYAN J. ELLIOTT
Affiliation:
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA
ANDREW P. DOBSON
Affiliation:
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA
OMAR TRIANA CHÁVEZ
Affiliation:
Grupo BCEI, Universidad de Antioquia, Calle 70 No. 52-21, Medellín, Colombia
*
*Corresponding author: Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA. E-mail: [email protected]
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Summary

Trypanosoma cruzi, causative agent of Chagas disease, co-infects its triatomine vector with its sister species Trypanosoma rangeli, which shares 60% of its antigens with T. cruzi. Additionally, T. rangeli has been observed to be pathogenic in some of its vector species. Although T. cruzi–T. rangeli co-infections are common, their effect on the vector has rarely been investigated. Therefore, we measured the fitness (survival and reproduction) of triatomine species Rhodnius prolixus infected with just T. cruzi, just T. rangeli, or both T. cruzi and T. rangeli. We found that survival (as estimated by survival probability and hazard ratios) was significantly different between treatments, with the T. cruzi treatment group having lower survival than the co-infected treatment. Reproduction and total fitness estimates in the T. cruzi and T. rangeli treatments were significantly lower than in the co-infected and control groups. The T. cruzi and T. rangeli treatment group fitness estimates were not significantly different from each other. Additionally, co-infected insects appeared to tolerate higher doses of parasites than insects with single-species infections. Our results suggest that T. cruzi–T. rangeli co-infection could ameliorate negative effects of single infections of either parasite on R. prolixus and potentially help it to tolerate higher parasite doses.

Keywords

Trypanosoma cruziTrypanosoma rangeliRhodnius prolixusT. cruzi–T. rangeli co-infectionChagas diseaseinfected-vector fitness
Type
Research Article
Information
Parasitology , Volume 143 , Issue 9 , August 2016 , pp. 1157 - 1167
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Copyright © Cambridge University Press 2016 

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