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Trichinella pseudospiralis overcomes innate resistance of the chinese hamster to Trichinella spiralis

Published online by Cambridge University Press:  06 April 2009

E. Larsen ,
G. L. Stewart  and
J. Y. Niederkorn
E. Larsen
Affiliation:
Center for Parasitology, Department of Biology, Box 19498, The University of Texas at Arlington, Arlington, Texas 76019, USA
G. L. Stewart
Affiliation:
Center for Parasitology, Department of Biology, Box 19498, The University of Texas at Arlington, Arlington, Texas 76019, USA
J. Y. Niederkorn
Affiliation:
Center for Parasitology, Department of Biology, Box 19498, The University of Texas at Arlington, Arlington, Texas 76019, USA
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Extract

Infectivity of Trichinella pseudospiralis in Chinese hamsters was greater than that of Trichinella spiralis. Concurrent infection with these two species of parasite was accompanied by an increase in infectivity of T. spiralis. The infectivity of T. pseudospiralis, but not that of T. spiralis, was significantly influenced by host age. Regardless of host age, T. pseudospiralis was more infective for the Chinese hamster than was T. spiralis. Early during infection, enteritis (myeloperoxidase activity) in hamsters infected with T. pseudospiralis alone was significantly less than that seen in animals infected with T. spiralis alone or with both species concurrently. Myositis in hamsters infected with T. pseudospiralis alone was significantly less on days 14, 17 and 25 post-infection (p.i.) than that observed in concurrently infected or T. spiralis-infected animals. On days 11 and 14 p.i. inflammation in diaphragm muscle from concurrently infected hamsters was significantly less than that seen in animals infected with T. spiralis alone. Muscle histology supported these chemical data on myositis. Suppression of the host inflammatory response against early muscle-stage larvae of T. pseudospiralis underlies the greater infectivity of this parasite for the Chinese hamster.

Keywords

Trichinella spiralisTrichinella pseudospiralismyositisenteritisChinese hamster
Type
Research Article
Information
Parasitology , Volume 103 , Issue 3 , December 1991 , pp. 465 - 470
Copyright
Copyright © Cambridge University Press 1991

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References

Concannon, J. & Ritterson, A. L. (1965). Comparative recoveries of adult worms from Chinese and golden hamsters fed known doses of Trichinella spiralis. Journal of Parasitology 51, 938–41.CrossRefGoogle ScholarPubMed
Dick, T. A. (1983). Species, and intraspecific variation. In Trichinella and Trichinosis (ed. Campbell, W. C.), pp. 31–73. New York: Plenum Press.CrossRefGoogle Scholar
Esch, G. W., Hazen, T. C. & Aho, J. M. (1977). Parasitism and r- and k-selection. In Regulation of Parasite Populations (ed. Esch, G. W.), pp. 9–62. New York: Academic Press.Google Scholar
Garkavi, B. L. (1972). Species of Trichinella isolated from wild animals. Veterinariya 10, 90–1.Google Scholar
Klebanoff, S. J., Waltersdorph, A. M. & Rosen, H. (1984). Antimicrobial activity of myeloperoxidase. In Methods In Enzymology, Vol. 105 (ed. Gallin, J. I. & Fauci, A. S.), pp. 399–403. New York: Academic Press.Google Scholar
Kramar, M., Stewart, G. L. & Charniga, L. (1981). Comparative study of Trichinella spiralis (Owen, 1835) and Trichinella pseudospiralis (Garkavi, 1972). Journal of Parasitology 67, 911–16.CrossRefGoogle ScholarPubMed
Maehly, A. C. & Chance, B. (1954). The assay of catalases and peroxidases. In Methods of Biochemical Analysis (ed. Glick, D.), pp. 357–408. New York: Interscience.CrossRefGoogle Scholar
Pryzjalkowski, Z. W., Cabaj, W. & Rykalo, R. (1983). Intestinal Trichinella spiralis and Trichinella pseudospiralis in germ-free and conventional mice. Progress in Food and Nutrition Science 7, 117–26.Google Scholar
Ritterson, A. L. (1957). The Chinese hamster (Crisetulus griseus) as an experimental host for Trichinella spiralis. Journal of Parasitology 43, 542–7.CrossRefGoogle Scholar
Ritterson, A. L. (1959). Innate resistance of hamsters to Trichinella spiralis and its reversal by cortisone. Journal of Infectious Diseases 105, 253–66.CrossRefGoogle ScholarPubMed
Sedmak, J. J. & Grossberg, S. F. (1977). A rapid, sensitive and versatile assay for protein using Coomassie Brilliant blue G-250. Analytical Biochemistry 79, 544–52.CrossRefGoogle Scholar
Smith, A. L., Rosenberg, I., Averill, D. R., Moxon, E. R., Stoessel, T. & Smith, D. H. (1974). Brain polymorphonuclear leukocyte quantitation by peroxidase assay. Infection and Immunity 10, 356–60.CrossRefGoogle ScholarPubMed
Smith, J. W. & Castro, G. A. (1978). Relation of peroxidase activity in gut mucosa to inflammation. American Journal of Physiology 234, R72–R79.Google ScholarPubMed
Stewart, G. L. (1989). Biological and immunological characteristics of Trichinella pseudospiralis. Parasitology Today 5, 344–9.CrossRefGoogle ScholarPubMed
Stewart, G. L., Charniga, L. & Boley, R. B. (1982 a). Myositis in mouse trichinellosis. Journal of Parasitology 68, 730–2.CrossRefGoogle ScholarPubMed
Stewart, G. L. & Deford, J. E. (1989). Nonenzymatic isolation of Trichinella pseudospiralis infective L1 larvae at pH 7.4. Journal of Parasitology 75, 171–3.CrossRefGoogle ScholarPubMed
Stewart, G. L., Kennedy, R. R. & Larsen, E. (1990). Alterations in the longevity and fecundity of adult Trichinella pseudospiralis related to method of isolation of infective larvae. Journal of Parasitology 76, 297–301.CrossRefGoogle ScholarPubMed
Stewart, G. L., Kramar, G. W., Kramar, M. & Charniga, L. (1982 b). The effects of cortisone on fecundity, number and distribution of adult Trichinella spiralis and trichinous enteritis in the host. Journal of Parasitology 68, 909–15.CrossRefGoogle ScholarPubMed
Stewart, G. L. & Larsen, E. (1989). Infection of the Chinese hamster with Trichinella pseudospiralis. Journal of Parasitology 75, 1006–7.CrossRefGoogle ScholarPubMed
Stewart, G. L., Mann, M. A., Ubelaker, J. E., McCarthy, J. L. & Wood, B. G. (1988). A role of elevated plasma corticosterone in modulation of host response during infection with Trichinella pseudospiralis. Parasite Immunology 10, 139–50.CrossRefGoogle ScholarPubMed
Stewart, G. L., Niederkorn, J. Y., Kennedy, R. R. & Mayhew, E. (1991). Effect of acute versus chronic Trichinella pseudospiralis infections on systemic cell-mediated immunity. International Journal for Parasitology (in the Press).CrossRefGoogle ScholarPubMed
Stewart, G. L., Wood, B. G. & Boley, R. B. (1985). Modulation of host response by Trichinella pseudospiralis. Parasite Immunology 7, 223–33.CrossRefGoogle ScholarPubMed