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Treatment efficacy and regulatory host responses in chronic experimental Schistosoma bovis infections in goats

Published online by Cambridge University Press:  20 April 2006

J. MONRAD ,
K. SÖRÉN ,
M. V. JOHANSEN ,
R. LINDBERG  and
N. ØRNBJERG
J. MONRAD
Affiliation:
Danish Centre for Experimental Parasitology, Royal Veterinary and Agricultural University, Dyrlaegevej 100, DK-1870 Frederiksberg C, Denmark
K. SÖRÉN
Affiliation:
Department of Biomedical Sciences and Veterinary Public Health, Division of Pathology, Pharmacology and Toxicology, Swedish University of Agricultural Sciences, S-75007 Uppsala, Sweden
M. V. JOHANSEN
Affiliation:
DBL-Institute for Health Research and Development, Jaegersborg Alle 1D, DK-2920 Charlottenlund, Denmark
R. LINDBERG
Affiliation:
Department of Biomedical Sciences and Veterinary Public Health, Division of Pathology, Pharmacology and Toxicology, Swedish University of Agricultural Sciences, S-75007 Uppsala, Sweden
N. ØRNBJERG
Affiliation:
DBL-Institute for Health Research and Development, Jaegersborg Alle 1D, DK-2920 Charlottenlund, Denmark
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Abstract

The aim of this study was to elucidate the regulatory responses and the long-term effect of praziquantel treatment in chronically Schistosoma bovis-infected West African Dwarf goats. Forty-two goats were used and the design comprised a primary infection followed by treatment at week 13, challenge infection at week 36 and termination at week 52. Dependent variables included clinico-pathological data, worm numbers, faecal and tissue egg counts, and gross pathology of the liver. The results showed that primary infections remained suppressed for up to 52 weeks and, although challenge infections imposed on 36-week-old primary infections established fully, the impairment of their egg production capacity provided protection against clinico-pathological consequences measured by body weight and haemoglobin levels. The study also confirmed a high efficacy (97·7%) of praziquantel for treatment of S. bovis infection in goats and showed that anthelminthic removal of primary infections does not interfere with the ability of the goat to elicit a marked resistance to a subsequent challenge infection. Although treated goats had more fibrous scarring of livers than untreated goats, no negative effects of liver lesions were reflected in weight gains of treated goats. This study provides strong evidence for the beneficial effects of anthelminthic treatment of young domestic stock as an element of treatment and preventive programmes.

Keywords

Schistosoma bovischronic infectionspraziquantel treatmentresistancegoats
Type
Research Article
Information
Parasitology , Volume 133 , Issue 2 , August 2006 , pp. 151 - 158
Copyright
2006 Cambridge University Press

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