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Subversion of host cell signalling by the protozoan parasite Leishmania

Published online by Cambridge University Press:  11 November 2005

D. J. GREGORY  and
M. OLIVIER
D. J. GREGORY
Affiliation:
Centre for the Study of Host Resistance at the Research Institute of the McGill University Health Centre, and Departments of Microbiology and Immunology, McGill University, Montréal, Québec, Canada
M. OLIVIER
Affiliation:
Centre for the Study of Host Resistance at the Research Institute of the McGill University Health Centre, and Departments of Microbiology and Immunology, McGill University, Montréal, Québec, Canada Experimental Medicine, McGill University, Montréal, Québec, Canada
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Abstract

The protozoa Leishmania spp. are obligate intracellular parasites that inhabit the macrophages of their host. Since macrophages are specialized for the identification and destruction of invading pathogens, both directly and by triggering an innate immune response, Leishmania have evolved a number of mechanisms for suppressing some critical macrophage activities. In this review, we discuss how various species of Leishmania distort the host macrophage's own signalling pathways to repress the expression of various cytokines and microbicidal molecules (nitric oxide and reactive oxygen species), and antigen presentation. In particular, we describe how MAP Kinase and JAK/STAT cascades are repressed, and intracellular Ca2+ and the activities of protein tyrosine phosphatases, in particular SHP-1, are elevated.

Keywords

LeishmaniamacrophageSHP-1PTPSTAT1nitric oxideMHC class II
Type
Research Article
Information
Parasitology , Volume 130 , Issue S1 , March 2005 , pp. S27 - S35
Copyright
© 2005 Cambridge University Press

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