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A study of acetylcholinesterase throughout the life cycle of Nippostrongylus brasiliensis

Published online by Cambridge University Press:  06 April 2009

Barbara E. Sanderson  and
Bridget M. Ogilvie
Barbara E. Sanderson
Affiliation:
The Research Laboratories, May and Baker Ltd, Dagenham, Essex and National Institute for Medical Research, Mill Hill, London, N. W. 7
Bridget M. Ogilvie
Affiliation:
The Research Laboratories, May and Baker Ltd, Dagenham, Essex and National Institute for Medical Research, Mill Hill, London, N. W. 7
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Extract

Acetylcholinesterase activity, measured per unit wet weight, is relatively low in the eggs and infective larvae of N. brasiliensis. It increases rapidly during the parasitic phase, especially in the late 3rd- and early 4th-larval stages. Activity in normal adults is extremely high (× 15 egg activity) and this is doubled again in immune-damaged adults. Possible functions of N. brasiliensis acetylcholinesterase are discussed.

It is a pleasure to acknowledge the technical assistance of Miss Anne Cronin and Miss Beryl Crooks.

Type
Research Article
Information
Parasitology , Volume 62 , Issue 3 , June 1971 , pp. 367 - 373
Copyright
Copyright © Cambridge University Press 1971

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References

REFERENCES

Bawden, R. J. (1970). The effects of nematode parasitism on the rate of passage of food residues through the alimentary tract of sheep. British Journal of Nutrition 24, 291–6.CrossRefGoogle ScholarPubMed
Crofton, H. D. (1966). Nematodes. London: Hutchinson University Library.Google Scholar
Edwards, A. J., Burt, J. S. & Ogilvie, B. M. (1971). The effect of immunity upon some enzymes of the parasitic nematode, Nippostrongylus brasiliensis. Parasitology, 62, 339–47.CrossRefGoogle ScholarPubMed
Erlanger, M. & Gershon, D. (1970). Studies on aging in nematodes. II. Studies of the activities of several enzymes as a function of age. Experimental Gerontology 5, 13–19.CrossRefGoogle ScholarPubMed
Gershon, D. (1970). Studies on aging in nematodes. I. The nematode as a model organism for aging research. Experimental Gerontology 5, 7–12.Google Scholar
Hart, R. J. & Lee, R. M. (1966). Cholinesterase activities of various nematode parasites and their inhibition by the organophosphate anthelmintic Haloxon. Experimental Parasitology 18, 332–7.CrossRefGoogle ScholarPubMed
Hestrin, S. (1949). The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application. Journal of Biological Chemistry 180, 249–61.CrossRefGoogle ScholarPubMed
Keeling, J. E. D. (1960). The effects of ultraviolet radiation on Nippostrongylus muris. I. Irradiation of infective larvae: lethal and sublethal effects. Annals of Tropical Medicine and Parasitology 54, 182–91.Google Scholar
Lee, D. L. (1969 a). Nippostrongylus brasiliensis: some aspects of the fine structure and biology of the infective larva and the adult. Symposia of the British Society for Parasitology 7, 3–16.Google Scholar
Lee, D. L. (1969 b). Changes in adult Nippostrongylus brasiliensis during the development of immunity to this nematode in rats. I. Changes in ultrastructure. Parasitology 59, 29–39.CrossRefGoogle Scholar
Lee, D. L. (1970). The fine structure of the excretory system in adult Nippostrongylus brasiliensis (Nematoda) and a suggested function for the ‘excretory glands’. Tissue and Cell 2, 225–31.Google Scholar
Lee, R. M. & Hodden, M. R. (1963). Cholinesterase activity in Haemonchus contortus and its inhibition by organophosphorus anthelmintics. Biochemical Pharmacology 12, 1241–52.Google Scholar
Michel, J. F. (1968). Immunity to helminths associated with the tissues. Symposia of the British Society for Parasitology 6, 67–89.Google Scholar
Nachmansohn, D. (1959). Chemical and Molecular Basis of Nerve activity. New York and London: Academic Press.Google Scholar
Nachmansohn, D. & Rothenberg, M. A. (1945). Studies on cholinesterase. Journal of Biological Chemistry 158, 653–66.Google Scholar
Ogilvie, B. M. & Hockley, D. J. (1968). Effects of immunity on Nippostrongylus brasiliensis adult worms: reversible and irreversible changes in infectivity, reproduction, and morphology. Journal of Parasitology 54, 1073–84.CrossRefGoogle ScholarPubMed
Ogilvie, B. M. & Jones, V. E. (1971). Nippostrongylus brasiliensis; a review of immunity and the host/parasite relationship in the rat. Experimental Parasitology (in the Press).CrossRefGoogle ScholarPubMed
Polyakova, O. I. (1967). (Cholinesterase activity in helminths). Zhurnal Evoljutionnoj Biokhimii i Fiziologii 3, 124–7. (In Russian.)Google Scholar
Sanderson, B. E. (1969). Acetylcholinesterase activity in Nippostrongylus brasiliensis (Nematoda). Comparative Biochemistry and Physiology 29, 1207–13.CrossRefGoogle ScholarPubMed
Snedecor, G. W. (1957). Statistical Methods, 5th ed.Ames, Iowa: Iowa State College Press.Google Scholar
Srivastava, V. K. & Subramanian, G. (1969). Studies on Bunostomum trigonocephalum (Rudolphi, 1808). III. Reinfection immunity in lambs. Indian Journal of Animal Sciences 39, 317–20.Google Scholar
Symons, L. E. A. (1966). Digestion and absorption of maltose in rats infected by the nematode Nippostrongylus brasiliensis. Experimental Parasitology 18, 12–24.Google Scholar