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Studies on the transmission and course of infection of a Kenyan strain of Theileria mutans

Published online by Cambridge University Press:  06 April 2009

A. S. Young ,
R. E. Purnell ,
R. C. Payne ,
C. G. D. Brown  and
G. K. Kanhai
A. S. Young*
Affiliation:
Immunological Research on Tick-borne Cattle Diseases and Tick Control Projectφ, East African Veterinary Research Organization, Muguga, P.O. Box 32, Kikuyu, Kenya
R. E. Purnell*
Affiliation:
Immunological Research on Tick-borne Cattle Diseases and Tick Control Projectφ, East African Veterinary Research Organization, Muguga, P.O. Box 32, Kikuyu, Kenya
R. C. Payne*
Affiliation:
Immunological Research on Tick-borne Cattle Diseases and Tick Control Projectφ, East African Veterinary Research Organization, Muguga, P.O. Box 32, Kikuyu, Kenya
C. G. D. Brown*
Affiliation:
Immunological Research on Tick-borne Cattle Diseases and Tick Control Projectφ, East African Veterinary Research Organization, Muguga, P.O. Box 32, Kikuyu, Kenya
G. K. Kanhai*
Affiliation:
Immunological Research on Tick-borne Cattle Diseases and Tick Control Projectφ, East African Veterinary Research Organization, Muguga, P.O. Box 32, Kikuyu, Kenya
*
*FAO Staff members.
†On ODM secondment from the ARC, Institute for Research on Animal Disease, Compton, Nr Newbury, Berkshire, to which he has now returned.
‡On ODM secondment from the Central Veterinary Laboratory, MAFF, New Haw, Weybridge, Surrey, to which he has now returned.
*FAO Staff members.
*FAO Staff members.
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Summary

Theileria mutans (Aitong) isolated from cattle exposed in the Narok District of Kenya and blood-passaged through cattle 8 times, appeared to have lost its original pathogenicity for cattle. It was demonstrated that the parasite was trans-stadially transmissible by the tick Amblyomma variegatum but not by Rhipicephalus appendiculatus. Four tick–bovine passages were made using A. variegatum, and infective parasites were also harvested from A. variegatum nymphs which had been fed for 5 days on rabbits. Blood containing piroplasms, or lymphoid cells infected with schizonts taken from cattle, at the 2nd tick–bovine passage were shown to be infective on inoculation.

The course of the T. mutans infections in the cattle was studied. In tick-induced infections macroschizonts occurred transiently, persisting longest in circulating lymphoid cells. Microschizonts were rarely detected. The macroschizonts were morphologically distinct from those of other Theileria species described from East Africa.

In tick-induced infections, the piroplasm parasitaemia increased rapidly and there was evidence of restored pathogenicity of the parasite since high piroplasm parasitaemias were associated with a marked anaemia.

Type
Research Article
Information
Parasitology , Volume 76 , Issue 1 , February 1978 , pp. 99 - 115
Copyright
Copyright © Cambridge University Press 1978

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References

REFERENCES

Bailey, K. P. (1960). Notes on the rearing of Rhipicephalus appendiculatus and their infection with Theileria parva for experimental transmission. Bulletin of Epizootic Diseases of Africa 8, 33–43.Google Scholar
Barnett, S. F. (1960). Connective tissue reaction in acute fatal East Coast fever (Theileria parva) of cattle. Journal of Infectious Diseases 107, 253–82.Google Scholar
Barnett, S. F. (1968). Theileriosis. In Infectious Blood Diseases of Man and Animals, vol. II (ed. Weinman, D. and Ristic, M.), pp. 269–328. London and New York: Academic Press.Google Scholar
Brocklesby, D. W. (1965). A new theilerial parasite of the African buffalo (Syncerus caffer). Bulletin of Epizootic Diseases of Africa 13, 325–30.Google ScholarPubMed
Brown, C. G. D., Stagg, D. A., Purnell, R. E., Kanhai, G. K. & Payne, R. C. (1973). Infection and transformation of bovine lymphoid cell in vitro by the infective particles of Theileria parva. Nature, London 245, 101–3.CrossRefGoogle ScholarPubMed
Brumpt, E. (1923). Les theileriosies mortelles du Bassin Méditeranéen sont dues a Theileria mutans. Annales de Parasitologie Humaine et Comparée 1, 16–53.CrossRefGoogle Scholar
Burridge, M. J. & Kimber, C. D. (1972). The indirect fluorescent antibody test for experimental East Coast fever (Theileria parva infection of cattle). Evaluation of a cell culture schizont antigen. Research in Veterinary Science 13, 451–5.CrossRefGoogle ScholarPubMed
Cunningham, M. P., Brown, C. G. D., Burridge, M. J. & Purnell, R. E. (1973). Cryopreservation of infective particles of Theileria parva. International Journal for Parasitology 3, 583–7.CrossRefGoogle ScholarPubMed
De Kock, G., Van Heerden, C. J., Du Toit, R. & Neitz, W. O. (1937). Bovine theileriasis in South Africa with special reference to Theileria mutans. Onderstepoort Journal of Veterinary Research 8, 9–125.Google Scholar
Du Toit, P. J. (1918). Zür Systematik der Piroplasmen. Archiv für Protistenkunde 39, 84–104.Google Scholar
França, C. (1912). Quelques consideration sur le genre Theileria et description d'une nouvelle éspece de ce genre (Theileria stordii) Zentralblatt für Bakteriologie, Parasitenkunde, Infektions-krankheiten und Hygiene 67, 171–5.Google Scholar
Hulliger, L., Wilde, J. K. H., Brown, C. G. D. & Turner, L. (1964). Mode of multiplication of Theileria in cultures of bovine lymphocytic cells. Nature, London 203, 728–30.CrossRefGoogle ScholarPubMed
Irvin, A. D., Brown, C. G. D., Burridge, M. J., Cunningham, M. P., Musoke, A. J., Peirce, M. A., Purnell, R. E. & Radley, D. E. (1972). A pathogenic theilerial syndrome of cattle in the Narok District of Kenya. I. Transmission studies. Tropical Animal Health and Production 4, 220–9.Google Scholar
Jarrett, W. F. H., Crighton, G. W. & Pirie, H. M. (1969). Theileria parva: kinetics of replication. Experimental Parasitology 24, 9–25.CrossRefGoogle ScholarPubMed
Kimber, C. D. & Young, A. S. (1977). Serological studies on strains of Theileria mutans isolated in East Africa using the indirect fluorescent antibody technique. Annals of Tropical Medicine and Parasitology 71, 1–10.Google Scholar
Kuttler, K. L., Robson, R. M. & Bell, R. R. (1967). Tick transmission of theileriosis in a white-tailed deer. Bulletin of the Wildlife Diseases Association 3, 182–3.CrossRefGoogle Scholar
Malmquist, W. A., Nyindo, M. B. A. & Brown, C. G. D. (1970). East Coast fever: cultivation in vitro of bovine spleen cell lines infected and transformed by Theileria parva. Tropical Animal Health and Production 2, 139–45.Google Scholar
Morzaria, S. P., Young, A. S., Kimber, C. D. & Brocklesby, D. W. (1977). The serological relationship of a British Theileria with other Theileria species using the indirect fluorescent antibody test. Research in Veterinary Science 22, 330–3.CrossRefGoogle ScholarPubMed
Neitz, W. O. (1955). Corridor disease, a fatal form of bovine theileriosis encountered in Zululand. Bulletin of Epizootic Diseases of Africa 3, 121–3.Google Scholar
Neitz, W. O. (1957). Theileriosis, gonderioses and cytauxzoonoses. A review. Onderstepoort Journal of Veterinary Research 27, 275–430.Google Scholar
Neitz, W. O. (1962). Review of recent developments in the protozoology of tick-borne disease. Report of the 2nd meeting of FAO/OIE Panel on tick-borne diseases of livestock, Cairo, 1962, pp. 34–5.Google Scholar
Oteng, A. K. (1972). Development of schizonts directly from the blood piroplasms of the Australian Theileria mutans. British Veterinary Journal 128, 23–xxv.Google ScholarPubMed
Purnell, R. E., Branagan, P. & Brown, C. G. D. (1970). Attempted transmission of some piroplasms by rhipicephalid ticks. Tropical Animal Health and Production 2, 146–50.CrossRefGoogle Scholar
Purnell, R. E., Young, A. S., Payne, R. C. & Mwangi, J. M. (1975). Development of Theileria mutans (Aitong) in the tick Amblyomma variegatum compared to that of Theileria parva (Muguga) in Rhipicephalus appendiculatus. Journal of Parasitology 61, 725–9.CrossRefGoogle Scholar
Radley, D. E., Brown, C. G. D., Burridge, M. J., Cunningham, M. P., Kirimi, I. M., Purnell, R. E. & Young, A. S. (1975). East Coast fever: 1. Chemoprophylactic immunization of cattle against Theileria parva (Muguga) and five theilerial strains. Veterinary Parasitology 1, 35–41.CrossRefGoogle Scholar
Radley, D. E., Brown, C. G. D., Burridge, M. J., Cunningham, M. P., Peirce, M. A. & Purnell, R. E. (1974). East Coast fever: quantitative studies of Theileria parva in cattle. Experimental Parasitology 36, 278&87.Google Scholar
Stagg, D. A., Kanhai, G. K., Young, A. S. & Brown, C. G. D. (1976). The establishment of Theileria-infected cell lines from an eland (Taurotragus oryx, Lydekker, 1906). Research in Veterinary Science 20, 122–6.CrossRefGoogle ScholarPubMed
Theiler, A. (1904). Some observations and experiments in connection with bovine piroplasmosis (East Coast fever or Rhodesian redwater). Journal of Comparative Pathology and Therapeutics 17, 193–203.CrossRefGoogle Scholar
Theiler, A. (1906). Piroplasma mutans (n. spec.) of South African cattle. Journal of Comparative Pathology and Therapeutics 19, 292–300.CrossRefGoogle Scholar
Theiller, A. (1907). Piroplasma mutans n. spec. A new species of Piroplasma and the disease caused by it. Report of Government Bacteriologist, Transvaal 1905–6, pp. 33–64.Google Scholar
Theiler, A. (1909). Transmission des spirilles et des piroplasmes par differentes épeces de tiques. Bulletin de la Société de Pathologie Exotique 2, 293–4.Google Scholar
Theiler, A. & Graf, H. (1928). Quelques observations récentes sur la nature de Gonderia mutans. Annales de Parasitologie Humaine et Comparée 6, 4–17.CrossRefGoogle Scholar
Uilenberg, G., McGregor, W., Mpangala, C., Callow, L. L. & De Vos, A. J. (1977). Relationship of some Theileria species of cattle. In Proceedings of the International Conference on Tick-borne Diseases and their Vectors.Edinburgh (in the Press).Google Scholar
Uilenberg, G., Robson, J. & Pedersen, V. (1974). Some experiments on the transmission of Theileria mutans (Theiler 1906) and Theileria parva (Theiler 1904) by the ticks Amblyomma variegatum (Fabricus 1794), and Rhipicephalus appendiculatus Neumann, 1901, in Uganda. Tropenmedizin und Parasitologie 25, 207–16.Google Scholar
Uilenberg, G., Schreuder, B. E. C. & Mpangala, C. (1976). Studies on Theileriidae (Sporozoa) in Tanzania. III Experiments on the transmission of Theileria mutans by Rhipicephalus appendiculatus and Amblyomma variegatum (Acarina Ixodidae). Tropenmedizin und Parasitologie 27, 323–8.Google ScholarPubMed
Walker, J. B. (1974). The Ixodid Ticks of Kenya. London: Commonwealth Agricultural Bureaux.Google Scholar
Wenyon, C. M. (1926). Protozoology. Vol. 2. London: Bailliere, Tiridal and Cox.Google Scholar
Yeoman, G. H. & Walker, J B. (1967). The Ixodid Ticks of Tanzania London: Commonwealth Institute of Entomology.Google Scholar
Young, A. S., Branagan, D., Brown, C. G. D., Burridge, M. J., Cunningham, M. P. & Purnell, R. E. (1973). Preliminary observations on a theilerial species pathogenic to cattle isolated from buffalo (Syncerus caffer) in Tanzania. British Veterinary Journal 129, 382–9.CrossRefGoogle ScholarPubMed
Young, A. S., Burridge, M. J. & Payne, R. C. (1977). Transmission of a Theileria species to cattle by the ixodid tick Amblyomma cohaerens Donitz, 1909. Tropical Animal Health and Production 9, 37–45.CrossRefGoogle ScholarPubMed
Young, A. S., Purnell, R. E., Payne, R. C. & Kimber, C. D. (1975). Correlation between the morphology and infectivity of Theileria lawrencei developing in the tick Rhipicephalus appendiculatus. Parasitology 71, 27–34.CrossRefGoogle ScholarPubMed