Hostname: page-component-586b7cd67f-dlnhk Total loading time: 0 Render date: 2024-11-28T05:46:53.644Z Has data issue: false hasContentIssue false
  • English
  • Français

Studies on the immunity of albino mice to Trichuris muris Suppression of immunity by cortisone acetate

Published online by Cambridge University Press:  06 April 2009

D. Wakelin
D. Wakelin
Affiliation:
Department of Zoology, Bedford College, London, N.W.1
Get access Rights & Permissions [Opens in a new window]

Summary

Cortisone acetate, given to mice on two days during a primary infection with the nematode Trichuris muris, suppressed the development of acquired immunity to the parasite. The proportion of mice in which suppression occurred was greatest when the drug was given (at 2.5 mg per mouse) on days 14 and 15 of the infection. Suppression of the response prevented the elimination of larvae, which otherwise occurs during the third week, and allowed the parasite population to mature and survive for at least a further 3 weeks. Similar treatment given during a challenge infection in resistant mice prevented the elimination of the challenge larvae for 2 or 3 days only. Mice in which cortisone treatment had prevented the elimination of a primary infection were not only found to be fully susceptible to subsequent challenge, but showed no development of immunity to the challenge infection itself. This long-lasting suppression of the immune response to T. muris is discussed and the possibility of the induction of a specific immunological unresponsiveness to the parasite is considered.

Type
Research Article
Information
Parasitology , Volume 60 , Issue 2 , April 1970 , pp. 229 - 237
Copyright
Copyright © Cambridge University Press 1970

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Berglund, K. (1962). Inhibition of antibody formation by prednisolone: location of a short sensitive period. Acta pathologica et microbiologica scandinavica 55, 187–202.Google Scholar
Campbell, W. C. (1963). Spontaneous cure in Trichuris muris infections in albino mice and its suppression by cortisone. Journal of Parasitology 49, 628–32.Google Scholar
Campbell, W. C. (1968). Effect of anti-inflammatory agents on spontaneous cure of Trichinella and Trichuris in mice. Journal of Parasitology 54, 452–6.CrossRefGoogle ScholarPubMed
Campbell, W. C. & Collette, J. V. (1962). Effect of cortisone upon infection with Trichuris muris in albino mice. Journal of Parasitology 48, 933–4.Google Scholar
Coker, C. M. (1955). Effects of cortisone on Trichinella spiralis infections in non-immunized mice. Journal of Parasitology 41, 498–504.CrossRefGoogle Scholar
Coker, C. M. (1956). Some effects of cortisone in mice with acquired immunity to Trichinella spiralis. Journal of Infectious Diseases 98, 39–44.CrossRefGoogle ScholarPubMed
Cross, J. H. (1960). The natural resistance of the white rat to Nematospiroides dubius and the effect of cortisone on this resistance. Journal of Parasitology 46, 175–85.CrossRefGoogle ScholarPubMed
Cross, J. H. (1963). Nematospiroides dubius in the abnormal host. Annals of the New York Academy of Sciences 113, 88–99.CrossRefGoogle ScholarPubMed
Darrach, M. (1959). Effect of steroids on antibody production in vivo. In The mechanisms of Hypersensitivity. Pp. 613–22. Eds. Shaffer, J. H., LoGrippo, G. A. and Chase, M. W.. Henry Ford Symposium. London: Churchill.Google Scholar
Gabrielson, A. E. & Good, R. A. (1966). Chemical suppression of adaptive immunity. Advances in Immunology 6, 92–231.Google Scholar
Jarrett, E. E. E., Jarrett, W. F. H. & Urquhart, G. M. (1966). Immunological unresponsiveness in adult rats to the nematode Nippostrongylus brasiliensis induced by infection in early life. Nature 211, 1310–11.Google Scholar
Kaliss, N., Hoeker, G. & Bryant, B. F. (1956). The effect of cortisone upon isohaemagglutinin production in mice. Journal of Immunology 76, 83–8.Google Scholar
Kassai, T. & Aitken, I. D. (1967). Induction of immunological tolerance in rats to Nippostrongylus brasiliensis infection. Parasitology 57, 403–18.Google Scholar
Markell, E. K. & Lewis, W. P. (1957). Effect of cortisone treatment on immunity to subsequent reinfection with Trichinella in the rat. American Journal of Tropical Medicine and Hygiene 6, 553–61.CrossRefGoogle ScholarPubMed
Mathies, A. W. (1962). Certain aspects of the host-parasite relationship of Aspiculuris tetraptera, a mouse pinworm. III. Effect of cortisone. Journal of Parasitology 48, 244–8.Google Scholar
Moriarty, K. M. (1966). Immunological unresponsiveness in the rat to cestode antigens. Experimental Parasitology 19, 25–33.Google Scholar
Ogilvie, B. M. (1965). Use of cortisone derivatives to inhibit resistance to Nippostrongylus brasiliensis and to study the fate of parasites in resistant hosts. Parasitology 55, 723–30.CrossRefGoogle Scholar
Olivier, L. (1962). Studies on natural resistance to Taenia taeniaeformis in mice. II. The effect of cortisone. Journal of Parasitology 48, 758–62.Google Scholar
Powers, K. G. (1962). Bionomics of the genus Trichuris Roederer, 1761, in sheep. Dissertation Abstracts 22, 2116–17.Google Scholar
Roman, E. (1956). Spécificit'infestation d'autres rongeurs par ce nématode. Annales de parasitologie humaine et comparée 31, 552–71.Google Scholar
Urquhart, G. M., Mulligan, W., Eadie, R. M. & Jennings, F. W. (1965). Immunological studies on Nippostrongylus brasiliensis infection in the rat: the role of local anaphylaxis. Experimental Parasitology 17, 210–17.CrossRefGoogle ScholarPubMed
Wakelin, D. (1967). Acquired immunity to Trichuris muris in the albino laboratory mouse. Parasitology 57, 515–24.CrossRefGoogle ScholarPubMed
Wakelin, D. (1969). Studies on the immunity of albino mice to Trichuris muris. The stimulation of immunity by chemically abbreviated infections. Parasitology 59, 549–55.Google Scholar