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Studies of antigens in Plasmodium yoelii

I. Antigenic differences between parasite lines detected by crossed immunoelectrophoresis

Published online by Cambridge University Press:  06 April 2009

Lindsey J. Panton ,
G. Knowles  and
D. Walliker
Lindsey J. Panton
Affiliation:
Department of Genetics, University of Edinburgh, West Mains Road, Edinburgh EH9 3JN
G. Knowles
Affiliation:
Department of Genetics, University of Edinburgh, West Mains Road, Edinburgh EH9 3JN
D. Walliker
Affiliation:
Department of Genetics, University of Edinburgh, West Mains Road, Edinburgh EH9 3JN
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Summary

Antigens of three lines of the rodent malaria parasite Plasmodium yoelii have been studied using crossed immunoelectrophoresis. P. y. yoelii line A1 is a mild line which is restricted to reticulocytes. P. y. yoelii line YM and P. y. nigeriensis line D1 are virulent infections which multiply in both immature and mature erythrocytes. One antigen, designated Py-1, was found to differ in its electrophoretic mobility between the lines, being fast (F) in lines A1 and YM and slow (S) in line D1. Antigen Py-1 also varied in quantity among the three lines; greater amounts were detected in parasites inhabiting mature erythrocytes than in those in reticulocytes. These characters were stable during blood and mosquito passage.

Type
Research Article
Information
Parasitology , Volume 89 , Issue 1 , August 1984 , pp. 17 - 26
Copyright
Copyright © Cambridge University Press 1984

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