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Studies of antigens in Plasmodium yoelii

II. Inheritance and recombination of antigenic characters

Published online by Cambridge University Press:  06 April 2009

Lindsey J. Panton ,
G. Knowles  and
D. Walliker
Lindsey J. Panton
Affiliation:
Department of Genetics, University of Edinburgh, West Mains Road, Edinburgh EH9 3JN
G. Knowles
Affiliation:
Department of Genetics, University of Edinburgh, West Mains Road, Edinburgh EH9 3JN
D. Walliker
Affiliation:
Department of Genetics, University of Edinburgh, West Mains Road, Edinburgh EH9 3JN
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Summary

The inheritance of an antigen designated Py-1 in the rodent malaria parasite Plasmodium yoelii has been investigated. A cross was made between 2 lines differing in the electrophoretic mobility and quantity of Py-1 detected by crossed immunoelectrophoresis. In 10 clones isolated from the progeny of the cross the level of Py-1 always correlated with the virulence of the infection and it was concluded that these characters were different phenotypic effects of the same gene mutation. The electrophoretic mobility of Py-1 segregated independently of the virulence character and was therefore controlled by a different gene. These two antigenic markers also recombined with isoenzyme and drug-sensitivity characters distinguishing the parent lines.

Type
Research Article
Information
Parasitology , Volume 89 , Issue 1 , August 1984 , pp. 27 - 34
Copyright
Copyright © Cambridge University Press 1984

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