Hostname: page-component-cd9895bd7-gvvz8 Total loading time: 0 Render date: 2024-12-26T00:45:19.431Z Has data issue: false hasContentIssue false
  • English
  • Français

Strongyloides ratti: the effect of betamethasone on the course of infection in rats

Published online by Cambridge University Press:  06 April 2009

R. Moqbel  and
D. A. Denham
R. Moqbel
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT
D. A. Denham
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT
Get access Rights & Permissions [Opens in a new window]

Summary

Rats were treated with betamethasone at different stages of infection with Strongyloides ratti. Treatment caused a diminution in the number of adult worms recovered but this residual population was not expelled as were worms from untreated rats. If treatment was started after expulsion had already begun adult worm numbers increased – suggesting that auto-infection occurred. Treatment throughout a primary infection prevented the development of an immune response which expelled, or killed, a challenge infection. Treatment, just before and just after challenge, prevented the expulsion of the challenge infection. Worm expulsion up to day 35 was prevented by treating rats with betamethasone 4, 6, 8 and 10 days after infection.

Type
Research Article
Information
Parasitology , Volume 76 , Issue 3 , June 1978 , pp. 289 - 298
Copyright
Copyright © Cambridge University Press 1978

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Behnke, J. M. (1975). Suppression of expulsion of Aspiculuris tetraptera in hydrocortisone and methotrexate treated mice. Parasitology 71, 109–16.CrossRefGoogle ScholarPubMed
Campbell, W. C. (1963). Spontaneous cure in Trichuris muris infections in albino mice and its suppression by cortisone. Journal of Parasitology 49, 628–32.CrossRefGoogle ScholarPubMed
Civantos, F. & Robinson, M. J. (1969). Fatal strongyloidiasis following corticosteroid therapy. American Journal of Digestive Diseases 14, 643.CrossRefGoogle ScholarPubMed
Coker, C. M. (1956). Some effects of cortisone in mice with acquired immunity to Trichinella spiralis. Journal of Infectious Diseases 98, 39–44.CrossRefGoogle ScholarPubMed
Cookson, J. B., Montgomery, R. D., Morgan, H. V. & Tudor, R. W. (1972). Fatal paralytic ileus due to strongyloidiasis. British Medical Journal 4, 771–2.CrossRefGoogle ScholarPubMed
Cruz, T., Rebougas, G. & Rocha, H. (1966). Fatal strongyloidiasis in patients receiving corticosteroids. New England Journal of Medicine 275, 1093–6.CrossRefGoogle ScholarPubMed
Markel, E. K. (1958). The effect of cortisone treatment upon the longevity and productivity of Trichinella spiralis in the rat. Journal of Infectious Diseases 102, 158–61.CrossRefGoogle Scholar
Markel, E. K. & Lewis, W. P. (1957). Effect of cortisone on immunity to subsequent reinfections with Trichinella in the rat. American Journal of Tropical Medicine and Hygiene 6, 553–61.CrossRefGoogle Scholar
Moqbel, R. & Denham, D. A. (1977). Strongyloides ratti: 1. parasitological observations on primary and secondary infections in the small intestine of rats. Journal of Helminthology 51, 301–7.CrossRefGoogle ScholarPubMed
North, R. J. (1972). The action of cortisone on cell-mediated immunity to infection: histogenesis of the lymphoid cell response and selective elimination of committed lymphocytes. Cellular Immunology 3, 501–5.CrossRefGoogle ScholarPubMed
Ogilvie, B. M. (1965). Use of cortisone derivatives to inhibit resistance to Nippostrongylus brasiliensis and to study the fate of parasites in resistant hosts. Parasitology 55, 723–30.CrossRefGoogle Scholar
Olivier, L. (1962). Studies on natural resistance to Taenia taeniaeformis in mice. II. The effect of cortisone. Journal of Parasitology 48, 758–62.CrossRefGoogle ScholarPubMed
Purtilo, D. T., Meyers, W. M. & Connor, D. H. (1974). Fatal strongyloidiasis in immunosuppressed patients. American Journal of Medicine 56, 488–93.CrossRefGoogle ScholarPubMed
Rivera, E., Madonado, M., Velez-Garcia, E., Grillo, A. J. & Malaret, G. (1970). Hyperinfection syndrome with Strongyloides stercoralis. Annals of Internal Medicine 72, 199–204.CrossRefGoogle ScholarPubMed
Rogers, W. A. Jr & Nelson, B. (1966). Strongyloidiasis and malignant lymphoma, ‘opportunistic infection’ by a nematode. Journal of the American Medical Association 195, 685–7.CrossRefGoogle ScholarPubMed
Wakelin, D. (1970). Studies on the immunity of albino mice to Trichuris muris; suppression of immunity by cortisone acetate. Parasitology 60, 229–37.CrossRefGoogle ScholarPubMed
Wakelin, D. & Selby, G. R. (1974). The induction of immunological tolerance to the parasitic nematode Trichuris muris in cortisone-treated mice. Immunology 26, 1–10.Google Scholar
Weinstein, P. P. (1955). The effect of cortisone on the immune response of the white rat to Nippostrongylus muris. American Journal of Tropical Medicine and Hygiene 14, 61–74.CrossRefGoogle Scholar
Yim, Y., Kikkawa, Y., Tanowitz, H. & Wittner, M. (1970). Fatal strongyloidiasis in Hodgkin's disease after immunosuppressive therapy. Journal of Tropical Medicine and Hygiene 73, 245–9.Google ScholarPubMed