Hostname: page-component-586b7cd67f-dsjbd Total loading time: 0 Render date: 2024-11-24T12:43:33.671Z Has data issue: false hasContentIssue false
  • English
  • Français

Strain variation in Entamoeba histolytica I. Correlation of invasiveness in rats with the clinical history and treatment of the experimental infections

Published online by Cambridge University Press:  06 April 2009

R. A. Neal  and
Patricia Vincent
R. A. Neal
Affiliation:
The Wellcome Laboratories of Tropical Medicine, London
Patricia Vincent
Affiliation:
The Wellcome Laboratories of Tropical Medicine, London
Get access Rights & Permissions [Opens in a new window]

Extract

1. Eleven strains of Entamoeba histolytica were isolated from contact carriers and all proved non-invasive to rats.

2. Three strains from cases showing symptoms proved invasive to rats.

3. The treatment of murine infection with non-invasive strains with emetine hydrochloride shows that most of them were successfully cured with six daily oral doses of 2 mg./kg., though one was not susceptible to this dose. Another proved refractory to 4 mg./kg.

4. The results of previous work with kittens are discussed in the light of the present observations.

Type
Research Article
Information
Parasitology , Volume 45 , Issue 1-2 , May 1955 , pp. 152 - 162
Copyright
Copyright © Cambridge University Press 1955

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Anderson, H. H., Bostick, W. L. & Johnstone, H. G. (1953). Amebiasis. Springfield, Illinois. C. C. Thomas.Google Scholar
Bond, V. P., Bostick, W., Hansen, E. L. & Anderson, H. H. (1946). Pathologic study of natural amebic infections in macaques. Amer. J. Trop. Med. 26, 625.CrossRefGoogle ScholarPubMed
Brumpt, E. (1928). Differentiation of the human intestinal amoebae with four-nucleated cysts. Trans. R. Soc. Trop. Med. Hyg. 22, 101.CrossRefGoogle Scholar
Brumpt, M. E. (1925). Étude sommaire de l'Entamoeba dispar n.sp. Amibe àkystes quadrinueléés, parasite de l'homme. Bull. Acad. Méd. Paris, 94, 943.Google Scholar
Burova, L. F. (1939). [Experimental study of histolytica-like amoebae in lower monkeys.] Bull. Biol. Méd. exp. URSS. 7, 249.Google Scholar
Burova, L. F. & Kakabadse, M. G. (1941). [Experimental study of strains of Entamoeba histolytica.] Trav. Acad. milit. Méd. 25, 360.Google Scholar
Dale, H. H. & Dobell, C. (1917). Experiments on the therapeutics of amoebic dysentery. J. Pharmacol. 10, 399.Google Scholar
Dobell, C. (1931). Researches on the intestinal Protozoa of monkey and man. IV. An experimental study of the histolytica-like species of Entamoeba living naturally in macaques. Parasitology, 23, 1.CrossRefGoogle Scholar
Faust, E. C., Heilbhunn, I., Lewis, R. & Murray, M. L. (1946). Differences in culturability, infectivity and pathogenicity of human strains of Endamoeba histolytica. Proc. Soc. Exp. Biol., N.Y., 63, 270.CrossRefGoogle ScholarPubMed
Hoare, C. A. (1950). Amoebiasis in Great Britain with special reference to carriers. Brit. Med. J. ii, 238.CrossRefGoogle Scholar
Hoare, C. A. (1952). The commensal phase of Entamoeba histolytica. Exp. Parasit. 1, 411.CrossRefGoogle Scholar
Ishii, Y. (1951). On the ulcer formation in the caecum at the site of experimental injection of Entamoeba histolytica. Kitasato Arch. 24, 235.Google Scholar
Johnson, C. M. (1941). Observations on natural infections of Endamoeba histolytica in Ateles and rhesus monkeys. Amer. J. Trop. Med. 21, 49.CrossRefGoogle Scholar
Jones, W. R. (1946). The experimental infection of rats with Entamoeba histolytica; with a method for evaluating the anti-amoebic properties of new compounds. Ann. Trop. Med. Parasit. 40, 130.CrossRefGoogle ScholarPubMed
Jones, W. R. (1947). The therapeutic action of some known amoebicides in rats. Brit. J. Pharmacol. 2, 217.Google ScholarPubMed
Kessel, J. F. (1928). Amoebiasis in kittens infected with amoebae from acute and ‘carrier’ human cases and with the tetranucleate amoebae of the monkey and of the pig. Amer. J. Hyg. 8, 311.Google Scholar
Matevossian, S., Sarkissian, M. & Markaryon, A. (1941). [Existence of strains of Entamoeba histolytica with different virulence.] Med. Parasitol., Moscow, 10, 264.Google Scholar
Meleney, H. E. & Frye, W. W. (1933). Studies of Endamoeba histolytica and other intestinal protozoa in Tennessee. V. A comparison of five strains of E. histolytica with reference to their pathogenicity for kittens. Amer. J. Hyg. 17, 637.Google Scholar
Meleney, H. E. & Frye, W. W. (1935). IX. Further observations on the pathogenicity of certain strains of E. histolytica for kittens. Amer. J. Hyg. 21, 422.Google Scholar
Meleney, H. E. & Frye, W. W. (1937). The pathogenicity of four strains of Endamoeba histolytica from Chicago. Amer. J. Dig. Dis. 4, 37.CrossRefGoogle Scholar
Meleney, H. E., Frye, W. W. & Leathers, W. S. (1939). The effect of prolonged cultivation on the pathogenicity of various strains of Endamoeba histolytica for kittens. Amer. J. Hyg. 29, C, 61.Google Scholar
Miller, M. J. (1952). The experimental infection of Macaca mulatta with human strains of Entamoeba histolytica. Amer. J. Trop. Med. Hyg. 1, 417.CrossRefGoogle ScholarPubMed
Morton, T. C., Stamm, W. P. & Seidelin, R. (1952). Indigenous amoebiasis: a recent outbreak in England. Brit. Med. J. ii, 114.CrossRefGoogle Scholar
Neal, R. A. (1951 a). Some observations on the variation of virulence and response to chemotherapy of strains of Entamoeba histolytica in rats. Trans. R. Soc. Trop. Med. Hyg. 44, 439.CrossRefGoogle ScholarPubMed
Neal, R. A. (1951 b). The duration and epidemiological significance of Entamoeba histolytica infections in rats. Trans. R. Soc. Trop. Med. Hyg. 45, 363.CrossRefGoogle ScholarPubMed
Neal, R. A. (1954). The influence of encystation upon the virulence of Entamoeba histolytica to rats. Trans. R. Soc. Trop. Med. Hyg. 48, 533.CrossRefGoogle ScholarPubMed
Okamoto, J. (1953). A comparison of strains of Entamoeba histolytica with special reference to their pathogenicity. II. On the rate of infection and ulcer formation in albino rats which were orally administered with cysts. Kitasato Arch. 26, 93.Google ScholarPubMed
Sarkissjan [ = Sarkissian], M. A. (1938). [Pathogénité des souches d'Entamoeba histolytica provenant de porteurs sains pour les chatons.] Med. Parasit., Moscow, 7, 123.Google Scholar
Simic, T. (1931). Étude experimentale complémentaire de l'Entamoeba dispar Brumpt, de Skopljie, sur le chat. Ann. Parasit. hum. comp. 9, 497.CrossRefGoogle Scholar
Simic, T. (1933). L'infection du chien par l'Entamoeba dispar Brumpt. Ann. Parasit. hum. comp. 11, 117.CrossRefGoogle Scholar
Ter-Matevossian, C., Sarkissian, M. & Zaturian, A. (1936). [Rôle pathogène de différentes souehes d'Entamoeba histolytica rencontrées en Armenie.] Med. Parasit., Moscow, 5, 108.Google Scholar
Tobie, J. E. (1940). Pathogenicity of “carrier” strains of Endamoeba histolytica in the experimental dog. Proc. Soc. exp. Biol., N.Y., 45, 691.CrossRefGoogle Scholar
Wagener, E. H. & Thomson, M. D. (1924). Experimental amoebiasis in cats from acute and chronic human cases. Univ. Calif. Publ. Zool. 26, 267.Google Scholar