Hostname: page-component-586b7cd67f-t7fkt Total loading time: 0 Render date: 2024-11-30T23:39:27.039Z Has data issue: false hasContentIssue false
  • English
  • Français

The stability of resistance to diminazene aceturate and quinapyramine sulphate in a strain of Trypanosoma vivax during cyclical transmission through antelope

Published online by Cambridge University Press:  06 April 2009

A. R. Gray  and
C. J. Roberts
A. R. Gray
Affiliation:
The Nigerian Institute for Trypanosomiasis Research, VomBenue-Plateau State, Nigeria
C. J. Roberts
Affiliation:
The Nigerian Institute for Trypanosomiasis Research, VomBenue-Plateau State, Nigeria
Get access Rights & Permissions [Opens in a new window]

Extract

A drug-resistant strain of T. vivax was transmitted through a series of four duikers (S. grimmia) and a gazelle (G. rufifrons) by G. palpalis and G. tachinoides. The cyclical transmission of the strain in cattle, started in earlier work, was continued for control purposes. Infections with the drug-resistant strain in the antelope were of the same type as those produced by field strains of T. vivax in the same host species, and infection rates in tsetse flies fed at early stages of infection on the antelope were similar to those found in flies fed on cattle infected with the drug-resistant strain. The strain retained resistance to diminazene aceturate at a dose rate of 7-0 mg/kg and quinapyramine sulphate at 5'0 mg/kg in the absence of the drugs for 7 months in tsetse flies and antelope, and for a total period of 29 months in tsetse flies and cattle.

We wish to thank Dr A. A. Amodu, Director of the Nigerian Institute for Trypanosomiasis Research, for permission to publish this paper.

Type
Research Article
Information
Parasitology , Volume 63 , Issue 1 , August 1971 , pp. 163 - 168
Copyright
Copyright © Cambridge University Press 1971

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Ashcroft, M. T. (1959). The importance of African wild animals as reservoirs of trypanosomiasis. East African Medical Journal 36, 289–97.Google Scholar
Cunningham, M. P., Van Hoeve, K. & Lumsden, W.H.R. (1966). A bio-assay technique for determination of trypanocidal drug levels, and its application in estimating the duration of activity of Berenil in treated cattle. In Proceedings of the 1st international Congress of Parasitology, pp. 301–3. Ed. Corradetti, A.Oxford: Pergamon Press.Google Scholar
Desowitz, R. S. (1959). Studies on immunity and host-parasite relationships. II. The immune response of antelope to trypanosomal challenge. Annals of Tropical Medicine and Parasitology 54, 281–92.Google Scholar
Finelle, P. & Yvore, P. (1962). Quelques observations sur la chimiorésistance. In International Scientific Committee for Trypanosomiasis Research, Ninth meeting, Conakry. C.C.T.A. Publication No. 88, pp. 107–10.Google Scholar
Fussganger, R. & Bauer, F. (1960). Investigations on Berenil resistance of trypanosomes. Veterinary Record 72, 1118–21.Google Scholar
Gray, A. R. & Roberts, C. J. (1971). The cyclical transmission of strains of Trypanosona congolense and T. vivax resistant to normal therapeutic doses of trypanocidal drugs. Parasitology 63, 67–90.Google Scholar
Lloyd, LI. & Johnson, W. B. (1924). The trypanosome infections of tsetse flies in Northern Nigeria and a new method of estimation. Bulletin of Entomological Research 14, 265–88.CrossRefGoogle Scholar
Weitz, B. (1963). The feeding habits of Glossina. Bulletin of the World Health Organization 28, 711–29.Google Scholar
Whiteside, E.F. (1960). Recent work in Kenya on the control of drug-resistant cattle trypanosomiasis. In International Scientific Committee for Trypanosomiasis Research, Eighth meeting, Joe. C.C.T.A. Publication No. 62, pp. 141–54.Google Scholar