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Specific immunosuppression by Trichinella: fine specificity and effect on lymphocyte function in vivo

Published online by Cambridge University Press:  06 April 2009

P. Baltar ,
J. Leiro ,
M. T. Santamarina ,
M. L. Sanmartín ,
M. C. Porto  and
F. M. Ubeira
P. Baltar
Affiliation:
Departamento de Microbiología y Parasitología, Universidad de Santiago de Compostela, Spain
J. Leiro
Affiliation:
Departamento de Microbiología y Parasitología, Universidad de Santiago de Compostela, Spain
M. T. Santamarina
Affiliation:
Departamento de Microbiología y Parasitología, Universidad de Santiago de Compostela, Spain
M. L. Sanmartín
Affiliation:
Departamento de Microbiología y Parasitología, Universidad de Santiago de Compostela, Spain
M. C. Porto
Affiliation:
Departamento de Radiologíay Radioterapia, Hospital Clínico, Santiago de Compostela, Spain
F. M. Ubeira
Affiliation:
Departamento de Microbiología y Parasitología, Universidad de Santiago de Compostela, Spain
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Extract

Muscle-phase Trichinella larvae depress the immune response of mice to the phosphorylcholine (PC)-bearing Trichinella antigen FCp without affecting responses to other PC-bearing or non-PC antigens. The depressive activity is independent of antigen dose and Trichinella species and, in adoptive cell transfer experiments with lethally irradiated recipient mice, depended on the state of the recipient (infected recipients had a depressed response even a month after their encysted larvae had been killed and regardless of whether the donor had been exposed to FCp) but not on the state of the transferred cells. We conclude that lymphocytes are not permanently altered by the depressive action, that the agent responsible persists in the host at least a month after the death of the encysted Trichinella larvae, and that the alteration does not eliminate lymphocyte immunological memory.

Keywords

Trichinella spp.lymphocyte functionimmunosuppression
Type
Research Article
Information
Parasitology , Volume 102 , Issue 3 , June 1991 , pp. 411 - 418
Copyright
Copyright © Cambridge University Press 1991

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