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Serine protease inhibitors of parasitic helminths

Published online by Cambridge University Press:  06 February 2012

ADEBAYO J. MOLEHIN ,
GEOFFREY N. GOBERT  and
DONALD P. McMANUS
ADEBAYO J. MOLEHIN*
Affiliation:
Molecular Parasitology Laboratory, Department of Biology, Queensland Institute of Medical Research, 300 Herston Road, Herston, Queensland, Australia 4006 School of Population Health, The University of Queensland, Herston Road, Herston, Queensland, Australia4006
GEOFFREY N. GOBERT
Affiliation:
Molecular Parasitology Laboratory, Department of Biology, Queensland Institute of Medical Research, 300 Herston Road, Herston, Queensland, Australia 4006
DONALD P. McMANUS
Affiliation:
Molecular Parasitology Laboratory, Department of Biology, Queensland Institute of Medical Research, 300 Herston Road, Herston, Queensland, Australia 4006
*
*Corresponding author: Molecular Parasitology Laboratory, Department of Biology, Queensland Institute of Medical Research, 300 Herston Road, Herston, Queensland, Australia4006. Tel: +61 73362 0405. Fax: +61 73362 0104. E-mail: [email protected]
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Summary

Serine protease inhibitors (serpins) are a superfamily of structurally conserved proteins that inhibit serine proteases and play key physiological roles in numerous biological systems such as blood coagulation, complement activation and inflammation. A number of serpins have now been identified in parasitic helminths with putative involvement in immune regulation and in parasite survival through interference with the host immune response. This review describes the serpins and smapins (small serine protease inhibitors) that have been identified in Ascaris spp., Brugia malayi, Ancylostoma caninum Onchocerca volvulus, Haemonchus contortus, Trichinella spiralis, Trichostrongylus vitrinus, Anisakis simplex, Trichuris suis, Schistosoma spp., Clonorchis sinensis, Paragonimus westermani and Echinococcus spp. and discusses their possible biological functions, including roles in host-parasite interplay and their evolutionary relationships.

Keywords

serine protease inhibitorsserpinssmall serine protease inhibitorssmapins biochemical characterizationparasitic helminths
Type
Review Article
Information
Parasitology , Volume 139 , Issue 6 , May 2012 , pp. 681 - 695
Copyright
Copyright © Cambridge University Press 2012

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