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Schistosoma mansoni: a histological study of migration in the laboratory mouse

Published online by Cambridge University Press:  06 April 2009

P.R. Wheater  and
R. A. Wilson
P.R. Wheater
Affiliation:
Department of Pathology, Medical School, University of Nottingham
R. A. Wilson
Affiliation:
Department of Biology, University of York
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Summary

Quantitative histological methods were applied in a study of the migratory route of schistosomula within the definitive mammal host. The observations are consistent with an entirely intravascular mode of migration in the direction of blood flow. They do not support a trans-diaphragm route. Schistosomula can be identified in low numbers in systemic organs, in the left side of the heart and in the venous compartment of the pulmonary circulation. They were not observed penetrating the diaphragm or the capsule of the liver. No histopathological evidence was found to suggest that the tissue responses of previously unexposed hosts affect migrating schistosomula at any stage during migration. These non-specific tissue responses were marked only in the skin phase of migration.

Type
Research Article
Information
Parasitology , Volume 79 , Issue 1 , August 1979 , pp. 49 - 62
Copyright
Copyright © Cambridge University Press 1979

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References

REFERENCES

Abboud, J. A., Hanna, L. S. & Ragab, H. A. A. (1971). Experimental ocular schistosomiasis. British Journal of Opthalmology 55, 106–15.CrossRefGoogle ScholarPubMed
Blahitka, J. & Rakusan, K. (1977). Blood flow in rats during haemorrhagic shock: differences between surviving and dying animals. Circulatory Shock 4, 79–93.Google ScholarPubMed
Cort, W. W. (1921). The development of the Japanese blood fluke Schistosoma japonicum Katsurada, in its final host. American Journal of Hygiene 1, 1–38.Google Scholar
Faust, E. C. (1948). An enquiry into the ectopic lesions in schistosomiasis. American Journal of Tropical Medicine 28, 175–99.Google Scholar
Faust, E. C., Jones, C. A. & Hoffman, W. A. (1934). Studies on schistosomiasis mansoni in Puerto Rico. III Biological studies. 2. The mammalian phase of the life cycle. Puerto Rico Journal of Public Health and Tropical Medicine 10, 133–96.Google Scholar
Faust, E. C. & Meleney, H. E. (1924). Studies on schistosomiasis japonica. American Journal of Hygiene, Monographic Series 3, 1–339.Google Scholar
Gordon, R. M. & Griffiths, R. B. (1951). Observations on the means by which cercariae of Schistosoma mansoni penetrate mammalian skin. Annals of Tropical Medicine and Parasitology 45, 227–43.CrossRefGoogle ScholarPubMed
Griffiths, R. B. (1953). Further observations on the penetration of mammalian skin by the cercariae of Schistosoma mansoni, with special reference to the effects of mass invasion. Annals of Tropical Medicine and Parasitology 47, 86–94.CrossRefGoogle Scholar
Kagan, I. C. & Meranze, O. R. (1955). The histopathology of immune and normal mouse skin exposed to the cercariae of Schistosomatium douthitti, Trematoda, Schistosomatidae. Journal of Infectious Diseases 97, 187–93.CrossRefGoogle Scholar
Kane, L. A. & Most, H. (1948). Schistosomiasis of the central nervous system: experiences in World War II and a review of the literature. Archives of Neurology and Psychiatry 59, 141–83.CrossRefGoogle Scholar
Koppisch, E. (1937). Studies on schistosomiasis mansoni in Puerto Rico IV. The pathological anatomy of experimental schistosomiasis mansoni in the rabbit and albino rat. Puerto Rico Journal of Public Health and Tropical Medicine 13, 1–54.Google Scholar
Kruger, S. P., Heitman, L. P., Van Wyk, J. A. & McCully, R. M. (1969). The route of migration of Schistosoma mattheei from lungs to liver in sheep. Journal of South African Veterinary Medical Association 40, 39–43.Google Scholar
Miller, P. (1976). Migration of the human blood fluke, Schistosoma mansoni and its subsequent development in the mammalian host. D.Phil. thesis, University of York.Google Scholar
Miller, P. & Wilson, R. A. (1978). Migration of the schistosomulum of Schistosoma mansoni from skin to lungs. Parasitology 77, 281–302.CrossRefGoogle Scholar
Miyagawa, Y. & Takemoto, S. (1921). The mode of infection of Schistosoma japonicum and the principal route of its journey from the skin to the portal vein of its host. Journal of Pathology and Bacteriology 24, 168–74.CrossRefGoogle Scholar
Sadun, E. H., Lin, S. S. & Williams, J. E. (1958). Studies on the host–parasite relationship to Schistosoma japonicum. I. The effect of single graded infections and the route of migration of schistosomula. American Journal of Tropical Medicine and Hygiene 7, 494–9.CrossRefGoogle ScholarPubMed
Smithers, S. R. & Terry, R. J. (1965). The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of adult worms. Parasitology 55, 695–700.CrossRefGoogle ScholarPubMed
Standen, O. D. (1953). The penetration of the cercariae of Schistosoma mansoni into the skin and lymphatics of the mouse. Transactions of the Royal Society of Tropical Medicine and Hygiene 47, 292–8.CrossRefGoogle ScholarPubMed
Standen, O. D. (1971). Drug activity against trematodes. Journal of Parasitology 57, Section II, 108–15.Google ScholarPubMed
Stirewalt, M. A. (1959). Chronological analysis, pattern, and route of migration of cercariae of Schistosoma mansoni in body, ear and tail skin of mice. Annals of Tropical Medicine and Parasitology 53, 400–13.CrossRefGoogle Scholar
Stirewalt, M. A. & Hackey, J. R. (1956). Penetration of host skin by cercariae of Schistosoma mansoni. I. Observed entry into skin of mouse, hamster, rat, monkey and man. Journal of Parasitology 42, 565–80.CrossRefGoogle Scholar
Stirewalt, M. A. & Dorsey, C. H. (1974). Schistosoma mansoni: cercarial penetration of host epidermis at the ultrastruetural level. Experimental Parasitology 35, 1–15.CrossRefGoogle Scholar
Tang, C. C., Tang, C. T. & Tang, C. (1973). Studies on the migratory route of Schistosoma japonicum in its final host. Acta zoologica sinica 19, 323–40.Google Scholar
Wilks, N. E. (1967). Lungs to liver migration of schistosomes in the laboratory mouse. American Journal of Tropical Medicine and Hygiene 16, 599–605.CrossRefGoogle ScholarPubMed
Wilson, R. A., Draskau, T., Miller, P. & Lawson, J. R. (1978). Schistosoma mansoni: the activity and development of the schistosomulum during migration from the skin to the hepatic portal system. Parasitology 77, 57–73.CrossRefGoogle Scholar
Yolles, T. K., Moore, D. V. & Meleney, H. E. (1949). Post-cercarial development of Schistosoma mansoni in the rabbit and hamster after intra-peritoneal and percutaneous infection. Journal of Parasitology 35, 276–94.CrossRefGoogle Scholar