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Retarded development of Schistosoma mansoni in immunosuppressed mice

Published online by Cambridge University Press:  06 April 2009

R. A. Harrison  and
M. J. Doenhoff
R. A. Harrison
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, 395 Hatfield Road, St Albans, Herts AL4 0XQ
M. J. Doenhoff
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, 395 Hatfield Road, St Albans, Herts AL4 0XQ
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Summary

Previous observations, which showed that treatment of mice with hydrocortisone acetate around the time of their infection with Schistosoma mansoni reduced the mature worm burden, have been confirmed. The number of eggs produced by the surviving worms during early patency was also significantly reduced. Cyclophosphamide and another steroid immunosuppressant, betamethasone, also caused a reduction in fecundity of S. mansoni when given at the time of infection, as did T-cell deprivation of the mice by adult thymectomy and injection of anti-thymocyte serum 1 month before infection. There was no effect of these three treatments on worm numbers. In contrast, injection of mice with anti-thymocyte serum at the time of infection marginally increased the size of the mature worm burden. The deleterious effects of hydrocortisone acetate on S. mansoni worm numbers and fecundity were only apparent if the steroid was given within 1 week of infection. Indomethacin, a compound which inhibits tissue inflammatory reactions by inhibiting prostaglandin synthesis, and which therefore mimics one of the actions of corticosteroids, had no effect on S. mansoni worm maturation and fecundity.

Type
Research Article
Information
Parasitology , Volume 86 , Issue 3 , June 1983 , pp. 429 - 438
Copyright
Copyright © Cambridge University Press 1983

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References

REFERENCES

Abdel-Wahab, M. F., Warren, K. S. & Levy, R. P. (1971). Function of the thyroid and the host-parasite relation in murine schistosomiasis mansoni. Journal of Infectious Diseases 124, 161–71.CrossRefGoogle Scholar
Bruce, J. I., Pezzlo, F., McCarty, J. E. & Yajima, Y. (1970). An electron microscope study of Schistosoma mansoni migration through mouse tissue. Ultrastructure of host skin and integument of migrating larva following cercarial penetration. American Journal of Tropical Medicine and Hygiene 19, 959–81.CrossRefGoogle Scholar
Bueding, E., Hawkins, J. & Cha, Y.-N. (1981). Antischistosomal effects of cyclosporin A. Agents and Actions 11, 380–3.CrossRefGoogle ScholarPubMed
Catto, B. A., Lewis, F. A. & Ottesen, E. A. (1980). Cercaria-induced histamine release. A factor in the pathogenesis of schistosome dermatitis. American Journal of Tropical Medicine and Hygiene 29, 886–9.CrossRefGoogle ScholarPubMed
Cheever, A. W. (1968). Conditions affecting the accuracy of potassium hydroxide digestion techniques for counting Schistosoma mansoni eggs in tissue. Bulletin of the World Health Organization 39, 328–31.Google Scholar
Coker, C. M. (1957). Effect of cortisone on natural immunity to Schistosoma mansoni in mice. Proceedings of the Society for Experimental Biology and Medicine 96, 1–3.CrossRefGoogle ScholarPubMed
Cruz, T., Reboucas, G. & Rocha, H. (1966). Fatal strongyloidiasis in patients receiving corticosteroids. New England Journal of Medicine 275, 1093–6.CrossRefGoogle ScholarPubMed
Doenhoff, M., Bickle, Q., Long, E., Bain, J. & McGregor, A. (1978). Factors affecting the acquisition of resistance against Schistosoma mansoni in the mouse. I. Demonstration of resistance to reinfection using a model system that involves perfusion of mice within three weeks of challenge. Journal of Helminthology 52, 173–86.CrossRefGoogle Scholar
Doenhoff, M., Harrison, R., Sabah, A., Murare, H., Dunne, D. & Hassounah, O. (1982). Schistosomiasis in the immunosuppressed host: studies on the host-parasite relationship of Schistosoma mansoni and S. bovis in T-cell deprived and hydrocortisone-treated mice. In Animal Models in Parasitology, (ed. Owen, D.), pp. 155–169. London: Macmillan.CrossRefGoogle Scholar
Doenhoff, M. & Leuchars, E. (1977). Effects of irradiation, anti-thymocyte serum and corticosteroids on PHA and LPS responsive cells of the mouse. International Archives of Allergy and Applied Immunology 53, 505–14.CrossRefGoogle ScholarPubMed
Doenhoff, M. & Long, E. (1978). Factors affecting the acquisition of resistance against Schistosoma mansoni in the mouse. IV. The inability of T-cell deprived mice to resist reinfection, and other in vivo studies on the mechanisms of resistance. Parasitology 78, 171–83.CrossRefGoogle Scholar
Doenhoff, M., Musallam, R., Bain, J. & McGregor, A. (1978). Studies on the host–parasite relationship in Schistosoma mansoni-infected mice: The immunological dependence of parasite egg excretion. Immunology 35, 771–8.Google ScholarPubMed
Doenhoff, M., Musallam, R., Bain, J. & McGregor, A. (1979). Schistosoma mansoni infections in T-cell deprived mice, and the ameliorating effect of administering chronic infection serum. I. Pathogenesis. American Journal of Tropical Medicine and Hygiene 28, 260–73.CrossRefGoogle ScholarPubMed
Kelly, J. D. (1972). Immunological suppression of parasite rejection by removal of selected lymphocyte populations; the effect of neonatal thymectomy and anti-lymphocyte serum administration on the resistance of rats to infection with the nematode Nippostrongylus brasiliensis. Australian Journal of Experimental Biology and Medical Science 50, 477–89.CrossRefGoogle Scholar
Knauft, R. F. & Warren, K. S. (1969). The effect of calorie and protein malnutrition on both the parasite and the host in acute murine schistosomiasis mansoni. Journal of Infectious Diseases 120, 560–75.CrossRefGoogle Scholar
Knopf, P. M. & Soliman, M. (1980). Effects of host endocrine gland removal on the permissive status of laboratory rodents to infections by Schistosoma mansoni. International Journal for Parasitology 10, 197–204.CrossRefGoogle ScholarPubMed
Kuehl, F. A. & Egan, R. W. (1980). Prostaglandins, arachidonic acid, and inflammation. Science 210, 978–84.CrossRefGoogle ScholarPubMed
Law, L. W., Bradley, T. R. & Rose, S. (1963). Reversal of the thymus dependent influence in radiation leukemagenesis of C57 Bl mice. Journal of the National Cancer Institute 31, 1461–77.Google Scholar
Levey, R. H. & Medawar, P. B. (1966). Some experiments on the action of antilymphoid antisera. Annals of the New York Academy of Sciences 129, 164–77.CrossRefGoogle Scholar
Lewert, R. M. & Mandlowitz, S. (1963). Innate immunity to Schistosoma mansoni relative to the state of the connective tissue. Annals of the New York Academy of Sciences 113, 54–62.CrossRefGoogle Scholar
Lewis, G. P. (1977). Prostaglandins in inflammation. Journal of the Reticuloendothelial Society 22, 389–402.Google ScholarPubMed
Lucas, S. B., Hassounah, O., Muller, R. & Doenhoff, M. J. (1980). Abnormal development of Hymenolepis nana larvae in immunosuppressed mice. Journal of Helminthology 54, 75–82.CrossRefGoogle ScholarPubMed
Moore, P. K. & Hoult, J. R. S. (1980). Anti-inflammatory steroids reduce tissue PG synthetase activity and enhance PG breakdown. Nature, London 288, 269–70.CrossRefGoogle ScholarPubMed
Robinson, E. J. (1960). Survival and developmental aberrations in Schistosoma mansoni following administration of Silbestrol to hosts. Journal of Helminthology 34, 81–4.CrossRefGoogle Scholar
Ruitenberg, E. J., Elgersama, A., Kruizinga, W. & Leenstra, F. (1977). Trichinella spiralis infection in congenitally athymic (nude) mice: Parasitological, serological and haematological studies with observations on intestinal pathology. Immunology 33, 581–7.Google ScholarPubMed
Rumjanek, F. D. & Cesari, I. M. (1981). The effects of indomethacin on lipid metabolism of Schistosoma mansoni. Biochemical Pharmacology 30, 3337–40.CrossRefGoogle ScholarPubMed
Smithers, S. R. & Terry, R. J. (1965). The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of adult worms. Parasitology 55, 695–700.CrossRefGoogle ScholarPubMed
Stirewalt, M. A. & Dorsey, C. A. (1974). Schistosoma mansoni: cercarial penetration of host epidermis at the ultrastructural level. Experimental Parasitology 35, 1–15.CrossRefGoogle ScholarPubMed
Torpier, G., Hirn, M., Nirde, P., de Reggi, M. & Capron, A. (1982). Detection of ecdysteroids in the human trematode Schistosoma mansoni. Parasitology 84, 123–30.CrossRefGoogle ScholarPubMed
Vane, J. B. (1971). Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature (New Biology) 231, 232–5.CrossRefGoogle ScholarPubMed
Weinmann, C. J. & Hunter, G. W. (1960). Studies on schistosomiasis. XIV. Effects of cortisone upon the Schistosoma mansoni burden in mice. Experimental Parasitology 9, 239–42.CrossRefGoogle Scholar
Wheater, P. R. & Wilson, R. A. (1979). Schistosoma mansoni: histological study of migration in the laboratory mouse. Parasitology 79, 49–62.CrossRefGoogle ScholarPubMed