Hostname: page-component-cd9895bd7-8ctnn Total loading time: 0 Render date: 2024-12-26T00:34:59.607Z Has data issue: false hasContentIssue false
  • English
  • Français

Resistance to primaquine in Plasmodium gallinaceum, and the problem of resistance to quinoline compounds in malaria parasites*

Published online by Cambridge University Press:  06 April 2009

Ann Bishop
Ann Bishop
Affiliation:
The Molteno Institute, University of Cambridge
Get access Rights & Permissions [Opens in a new window]

Extract

A tenfold enhancement of resistance to primaquine was obtained by maintaining a strain of Plasmodium gallinaceum in a state of acute infection by serial passage of infected blood through young chicks treated with gradually increasing doses of the drug.

No loss in resistance to primaquine was observed when the resistant strain was transmitted through mosquitoes, though there was some loss in resistance to the maximum tolerated dose, but not to lower doses, when the strain was maintained in a state of acute infection through untreated chicks for 41 weeks.

The primaquine-resistant strain was cross-resistant to lower effective doses of pamaquin, and slightly less sensitive to quinine than the parent strain but the loss in sensitivity to chloroquine was only marginal. Sensitivity to proguanil, dihydrotriazine and pyrimethamine was normal.

Attempts were made to produce a chloroquine-resistant strain of P. gallinaceum using different doses of the drug but no change in sensitivity was observed though the experiments were continued for more than a year. An attempt to produce a chloroquine-resistant strain by treatment of a proguanil-resistant strain with chloroquine also failed.

The problem of resistance to quinoline compounds in different species of Plasmodium is discussed.

Type
Research Article
Information
Parasitology , Volume 57 , Issue 4 , November 1967 , pp. 755 - 770
Copyright
Copyright © Cambridge University Press 1967

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Arnold, J., Alving, A. S., Clayman, C. B. & Hochwald, R. S. (1961). Induced primaquine resistance in vivax malaria. Trans. R. Soc. trop. Med. Hyg. 55, 345–50.CrossRefGoogle ScholarPubMed
Bishop, A. (1954). The effect of sulphadiazine, proguanil and 2:4-diamino-6:7-diisopro-pylpteridine upon gametocyte production in Plasmodium gallinaceum (Brumpt, 1935). Parasitology 44, 120–31.CrossRefGoogle ScholarPubMed
Bishop, A. (1958). An analysis of the development of resistance to metachloridine in clones of Plasmodium gallinaceum. Parasitology 48, 210–34.CrossRefGoogle ScholarPubMed
Bishop, A. (1962). An analysis of the development of resistance to proguanil and pyrimethamine in Plasmodium gallinaceum. Parasitology 52, 495–518.CrossRefGoogle Scholar
Bishop, A. & Birkett, B. (1948). Drug-resistance in Plasmodium gallinaceum and the persistence of paludrine-resistance after mosquito transmission. Parasitology 39, 125–37.CrossRefGoogle ScholarPubMed
Bishop, A. & McConnachie, E. W. (1950 a). The stability of paludrine resistance in Plasmodium gallinaceum. Parasitology 40, 159–62.CrossRefGoogle ScholarPubMed
Bishop, A. & McConnachie, E. W. (1950 b). Sulphadiazine-resistance in Plasmodium gallinaceum and its relation to other antimalarial compounds. Parasitology 40, 163–74.CrossRefGoogle ScholarPubMed
Bishop, A. & McConnachie, E. W. (1952 a). Failure to produce resistance to chloroquine in Plasmodium gallinaceum in chicks. Parasitology 42, 52–6.CrossRefGoogle ScholarPubMed
Bishop, A. & McConnachie, E. W. (1952 b). Pamaquin resistance in a strain of Plasmodium gallinaceum and its relationship to other antimalarial drugs. Parasitology 42, 57–64.CrossRefGoogle Scholar
Ciak, J. & Hahn, F. E. (1966). Chloroquine: mode of action. Science N.Y. 151, 347–9.CrossRefGoogle ScholarPubMed
Coatney, G. R. (1963). Pitfalls in a discovery: the chronicle of chloroquine. Am. J. trop. Med. Hyg. 12, 121–8.CrossRefGoogle Scholar
Contacos, P. G., Lunn, J. S. & Coatney, R. (1963). Drug-resistant falciparum malaria from Cambodia and Malaya. Trans. R. Soc. trop. Med. 57, 417–24.CrossRefGoogle ScholarPubMed
DeGowin, R. L., Eppes, R. B., Carson, P. E. & Powell, R. D. (1966). The effect of diaphenylsulfone (DDS) against chloroquine-resistant Plasmodium falciparum. Bull. Wld. Hlth. Org. 34, 671–81.Google ScholarPubMed
DeGowin, R. L. & Powell, R. D. (1965). Drug resistance of a strain of Plasmodium falciparum from Malaya. Am. J. trop. Med. Hyg. 14, 519–28.CrossRefGoogle Scholar
Edeson, J. F. D. & Field, J. W. (1950). Proguanil-resistant falciparum malaria in Malaya. Br. med. J. 1, 147–51.CrossRefGoogle ScholarPubMed
Eyles, D. E., Hoo, C. C., Warren, McW. & Sandosham, A. A. (1963). Plasmodium falciparum resistant to chloroquine in Cambodia. Am. J. trop. Med. Hyg. 12, 840–3.CrossRefGoogle ScholarPubMed
Fairley, N. H. (1946). Atebrin susceptibility of the Aitaipe-Wewak strains of P. falciparum and P. vivax; a field and experimental investigation by L.H.Q. Medical Research Unit Cairns. Trans. B. Soc. trop. Med. Hyg. 40, 229.CrossRefGoogle Scholar
Fulton, J. D. & Yorke, W. (1941). Studies in chemotherapy. XXIX. The development of plasmoquine-resistance in Plasmodium knowlesi. Ann. trop. Med. Parasit. 35, 233–9.CrossRefGoogle Scholar
Hawking, F. (1966 a). Arsenical resistance and tartar emetic resistance. Trans. R. Soc. trop. Med. 60, 123–4.CrossRefGoogle Scholar
Hawking, F. (1966 b). Chloroquine resistance in Plasmodium berghei. Am. J. trop. Med. Hyg. 15, 287–93.CrossRefGoogle ScholarPubMed
Hawking, F. & Gammage, K. (1962). Chloroquine resistance produced in Plasmodium berghei. Trans. R. Soc. trop. Med. Hyg. 56, 263.CrossRefGoogle Scholar
Jacobs, R. L. (1965). Selection of strains of Plasmodium berghei resistant to quinine, chloroquine and pyrimethamine. J. Parasit. 51, 481–2.CrossRefGoogle Scholar
James, S. P., Nicol, W. D. & Shute, P. G. (1932). A study of induced malignant tertian malaria. Proc. R. Soc. Med. 25, 1153.Google ScholarPubMed
Knoppers, A. T. (1947). Acquired resistance (twofold) to quinine in Plasmodium gallinaceum. Nature, Lond. 160, 606–7.CrossRefGoogle ScholarPubMed
Knoppers, A. T. (1949). Twofold quinine resistance of Plasmodium gallinaceum induced by regular administration of the drug. Docum. neerl. indones. Morb. trop. 1, 55–66.Google ScholarPubMed
Macomber, P. B., O'Brien, R. L. & Hahn, F. E. (1966). Physiological basis of drug resistance in Plasmodium berghei. Science N.Y. 152, 1374–5.CrossRefGoogle ScholarPubMed
Mesnil, F. & Brimont, E. (1908). Sur une race de trypanosomes résistante à 1'émétique et sur l'évaluation in vitro de sa résistance. C.r. Séanc. Soc. Biol. 64, 820–3.Google Scholar
Montgomery, R. & Eyles, D. E. (1963). Chloroquine resistant falciparum malaria in Malaya. Trans. R. Soc. trop. Med. Hyg. 57, 409–16.CrossRefGoogle ScholarPubMed
Moore, D. V. & Lanier, J. E. (1961). Observations on two Plasmodium falciparum infections with an abnormal response to chloroquine. Am. J. trop. Med. Hyg. 10, 5–9.CrossRefGoogle ScholarPubMed
Nauck, E. G. (1934). Chemotherapeutische Versuche bei Affenmalaria (Pl. knowlesi). Arch. Schiffs-u. Tropenhyg. 38, 313–26.Google Scholar
Newton, B. A. (1964). Mechanisms of action of phenanthridine and aminoquinaldine trypanocides. Adv. Chemother. 1, 36–83.Google Scholar
Peters, W. (1965 a). Mepacrine- and primaquine-resistant strains of Plasmodium berghie Vincke and Lips, 1948. Nature, Lond. 208, 693–4.CrossRefGoogle Scholar
Peters, W. (1965 b). Drug resistance in Plasmodium berghei Vincke and Lips, 1948. I. Chloroquine resistance. Expl Parasit. 17, 80–9.CrossRefGoogle ScholarPubMed
Peters, W. (1965 c). Drug resistance in Plasmodium berghei Vincke and Lips, 1948. II. Triazine resistance. Expl Parasit. 17, 90–6.CrossRefGoogle ScholarPubMed
Peters, W. (1965 d). Drug resistance in Plasmodium berghei Vincke and Lips, 1948. III. Multiple drug resistance. Expl Parasit. 17, 97–102.CrossRefGoogle Scholar
Peters, W. (1966). Drug responses of mepacrine- and primaquine-resistant strains of Plasmodium berghei Vincke & Lips, 1948. Ann. trop. Med. Parasit. 60, 25–30.CrossRefGoogle ScholarPubMed
Powell, R. D., Brewer, G. J. & Alving, A. S. (1963). Studies on a strain of chloroquine resistant Plasmodium falciparum from Colombia, South America. Am. J. trop. Med. Hyg. 12, 509–12.CrossRefGoogle ScholarPubMed
Prakash, S., Chakrabarti, A. K. & Choudhury, D. S. (1961). Studies on Plasmodium berghei Vincke and Lips, 1948. XXXI. Selection of a primaquine resistant strain. Indian J. Malar. 15, 115–22.Google ScholarPubMed
Ramakrishnan, S. P., Prakash, S. & Choudhury, D. S. (1957). Studies on Plasmodium berghei Vineke and Lips, 1948. XXIV. Selection of a chloroquine resistant strain. Indian J. Malar. 11, 213–20.Google Scholar
Ray, A. P., Sharma, G. K. & Misra, B. G. (1956). Screening of antimalarials against P. gallinaceum in chicks. Part V. Evidence of two-fold acquired resistance to chloroquine diphosphate in a strain of P. gallinaceum in chicks. Indian J. Malar. 10, 299–304.Google Scholar
Sautet, J., Aldighieri, J. & Aldighieri, R. (1959). Etudes sur la production expérimentale de la résistance à divers produits antimalariques d'une souche de Plasmodium berghei. Bull. Soc. Path. exot. 52, 331–44.Google Scholar
Schellenberg, K. A. & Coatney, G. R. (1961). The influence of antimalarial drugs on nucleic acid synthesis in Plasmodium gallinaceum and Plasmodium berghei. Biochem. Pharmac. 6, 143–52.CrossRefGoogle ScholarPubMed
Schmidt, L. H., Genther, C. S., Fradkin, R. & Squires, W. (1949). Development of resistance to chlorguanide (paludrine) during treatment of infections with Plasmodium cynomolgi. J. Pharmac. exp. Ther. 95, 382–98.Google ScholarPubMed
Seaton, D. R. (1951). Failure to induce chloroquine-resistance in Plasmodium gallinaceum. Ann. trop. Med. Parasit. 45, 99–100.CrossRefGoogle ScholarPubMed
Williamson, J. & Lourie, E. M. (1947). Acquired paludine-resistance in Plasmodium gallinaceum. I. Development of resistance to paludrine and failure to develop resistance to certain other antimalarials. Ann. trop. Med. Parasit. 41, 278–91.CrossRefGoogle ScholarPubMed
Yorke, W., Murgatroyd, F. & Hawking, F. (1932). Studies in chemotherapy. VIII. Comparison of strains of T. rhodesiense made resistant to various arsenicals and antimonials, to Bayer 205, and to acriflavine, respectively. Ann. trop. Med. Parasit. 26, 577–86.CrossRefGoogle Scholar
Young, M. D. & Moore, D. V. (1961). Chloroquine resistance in Plasmodium falciparum. Am. J. trop. Med. Hyg. 10, 317–20.CrossRefGoogle ScholarPubMed