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Researches on the Intestinal Protozoa of Monkeys and Man

V. The Endolimax of Macaques

Published online by Cambridge University Press:  06 April 2009

Clifford Dobell
Clifford Dobell
Affiliation:
National Institute for Medical Research, London, N.W.3.
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Extract

Amoebae of the genus Endolimax have been found naturally inhabiting the large intestine of 3 species of Macacus (M. sinicus [= radiatus], M. rhesus [= mulatto], M. nemestrinus).

In all these hosts the amoebae are morphologically and culturally identical, at all stages of development, and are indistinguishable by any structural or cultural character from Endolimax nana of Man—with which they have been carefully compared. The several forms have been studied in “pure” culture (i.e., free from all other protozoa, but accompanied by bacteria suitable for their growth).

The Endolimax of M. sinicus, isolated in “pure” culture, has been experimentally transmitted to an uninfected man by the natural route (cysts per os): and in this human subject it has produced an infection indistinguishable from a natural one with E. nana. The induced infection has now persisted unchanged for close on 8 years.

From the experimentally infected man the amoeba has been artificially transmitted to an uninfected M. rhesus, in which it gave rise to an infection—likewise indistinguishable from a natural simian infection—which persisted for the rest of the monkey's life (2½ years).

Some further information is given about the distribution, cultivation, emetine-resistance, and other peculiarities of the forms of Endolimax found in Macaques and Man; and the findings of other workers with similar organisms are briefly considered. From all the evidence available it is concluded that E. nana naturally lives not only in Man but also in at least 3 different species of Macacus, and probably in monkeys of this genus generally. As yet there is no evidence that more than one species of Endolimax inhabits any of these hosts.

Infections with E. nana, whether in Man or Macaques, have usually been found to endure indefinitely; but a case (M. rhesus) has been observed in which the infection appears to have died out spontaneously after persisting for a known period of over 6 years.

Attempts to infect kittens with E. nana have all been unsuccessful hitherto, but there is evidence (from the work of others) that this amoeba may inhabit some other domestic mammals. Its host-distribution in nature needs further investigation.

Type
Research Article
Information
Parasitology , Volume 25 , Issue 4 , December 1933 , pp. 436 - 467
Copyright
Copyright © Cambridge University Press 1933

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