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Reduction of niridazole by metronidazole resistant and susceptible strains of Trichomonas vaginalis

Published online by Cambridge University Press:  06 April 2009

N. Yarlett ,
C. C. Rowlands ,
Nuriza C. Yarlett ,
J. C. Evans  and
D. Lloyd
N. Yarlett
Affiliation:
Departments of Microbiology, University College, Newport Road, Cardiff CF2 1TA
C. C. Rowlands
Affiliation:
Departments of Chemistry, University College, Newport Road, Cardiff CF2 1TA
Nuriza C. Yarlett
Affiliation:
Departments of Microbiology, University College, Newport Road, Cardiff CF2 1TA
J. C. Evans
Affiliation:
Departments of Chemistry, University College, Newport Road, Cardiff CF2 1TA
D. Lloyd*
Affiliation:
Departments of Microbiology, University College, Newport Road, Cardiff CF2 1TA
*
║All correspondence to Professor D. Lloyd.
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Summary

The inhibitory effect of niridazole on hydrogen production by metronidazole-resistant (CDC-85) and susceptible (Cl-NIH) Trichomonas vaginalis strains was investigated. The results show that niridazole is more effective than metronidazole in inhibiting hydrogen production by the resistant isolate. In CDC-85 aerobic inhibition requires a 4-fold increase in metronidazole concentration compared with that required anaerobically, but the corresponding factor for niridazole is only 1·5-fold. Reduction of the drug by a hydrogenosome-enriched preparation gave rise to a multiline electron spin resonance detectable signal, which is due to a nitrogen-centred radical.

Type
Research Article
Information
Parasitology , Volume 94 , Issue 1 , February 1987 , pp. 93 - 99
Copyright
Copyright © Cambridge University Press 1987

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