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Praziquantel-induced tegumental damage in vitro is diminished in schistosomes derived from praziquantel-resistant infections

Published online by Cambridge University Press:  11 January 2002

S. WILLIAM ,
S. BOTROS ,
M. ISMAIL ,
A. FARGHALLY ,
T.A. DAY  and
J.L. BENNETT
S. WILLIAM
Affiliation:
Department of Pharmacology, Theodor Bilharz Research Institute, Cairo, Egypt
S. BOTROS
Affiliation:
Department of Pharmacology, Theodor Bilharz Research Institute, Cairo, Egypt
M. ISMAIL
Affiliation:
Faculty of Parasitology, Zagazig University, Zagazig, Egypt
A. FARGHALLY
Affiliation:
Faculty of Parasitology, Zagazig University, Zagazig, Egypt
T.A. DAY
Affiliation:
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA
J.L. BENNETT
Affiliation:
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA
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Abstract

The aggressive use of praziquantel to combat schistosomiasis in Egpyt raises concern about the possible emergence of resistance. Eggs from Egyptian patients with praziquantel-resistant infections (not cured by 3 doses of praziquantel) have been used to establish infection-specific schistosome isolates in mice. The response of these worms to the drug was observed in vitro, in order to determine if the isolates obtained from these resistant infections were, in fact, less responsive to praziquantel. One of the hallmark effects of praziquantel on schistosomes in vitro is a disruption of the worm's outer surface, the tegument. Here, praziquantel-induced tegumental damage is observed in 3 distinct isolates, 2 derived from resistant infections and 1 from an infection cured by a single dose. The isolates from the resistant infections were less susceptible to praziquantel-induced tegumental damage in vitro, suggesting that the worms are in some way less responsive to the drug.

Keywords

praziquantelSchistosoma mansoniresistancetegumental damage
Type
Research article
Information
Parasitology , Volume 122 , Issue 1 , January 2001 , pp. 63 - 66
Copyright
© 2001 Cambridge University Press

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