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Praziquantel treatment of Biomphalaria glabrata infected with Schistosoma mansoni– influence on snail fecundity

Published online by Cambridge University Press:  06 April 2009

E. M. Riley  and
L. H. Chappell
E. M. Riley
Affiliation:
Department of Zoology, University of Aberdeen, Tillydrone Avenue, Aberdeen AB9 2TN
L. H. Chappell
Affiliation:
Department of Zoology, University of Aberdeen, Tillydrone Avenue, Aberdeen AB9 2TN
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Extract

Praziquantel, administered over a 72 h period in the food of mature Biomphalaria glabrata harbouring 7-week-old Schistosoma mansoni infections, dramatically reduced the numbers of cercariae shed. Doses of 20–30 μg/g body weight (including shell weight) reduced shedding by 85–95% over 5 weeks before recovery was evident. Suppression of cercarial shedding in these infections was accompanied by the temporary recovery of the snail reproductive regression due to S. mansoni infection. Snail fecundity was subsequently re-suppressed 2 weeks prior to recovery of the parasite as evidenced by a resumption of cercarial shedding. Praziquantel destroyed mature and developing cercariae within the daughter sporocysts but had no apparent effect on daughter sporocysts; this may account for the eventual resumption of cercarial production. Reproductive failure of the snail is apparently related to the latter stages of cercarial development specifically. Reproductive recovery did not occur when snails were infected as juveniles or when mature-infected snails harboured 12–5 week i.e. older infections: drug treatment temporarily inhibited cercarial production but no snails produced eggs.

Keywords

Schistosoma mansoniBiomphalaria glabratapraziquantelfecundity
Type
Research Article
Information
Parasitology , Volume 101 , Issue 2 , October 1990 , pp. 211 - 217
Copyright
Copyright © Cambridge University Press 1990

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