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Plasmodium vivax malaria in the common marmoset, Callithrix jacchus: adaptation and host response to infection

Published online by Cambridge University Press:  06 April 2009

G. H. Mitchell ,
D. A. Johnston ,
B. A. Naylor ,
A. M. Knight  and
N. Wedderburn
G. H. Mitchell
Affiliation:
Department of Immunology, UMDS, The Medical School, Guy's Hospital, London SE1 9RT
D. A. Johnston
Affiliation:
Department of Immunology, UMDS, The Medical School, Guy's Hospital, London SE1 9RT Department of Pathology, Hunterian Institute, Royal College of Surgeons of England, Lincoln's Inn Fields, London WC2A 3PN
B. A. Naylor
Affiliation:
Department of Pathology, Hunterian Institute, Royal College of Surgeons of England, Lincoln's Inn Fields, London WC2A 3PN
A. M. Knight
Affiliation:
Department of Immunology, UMDS, The Medical School, Guy's Hospital, London SE1 9RT
N. Wedderburn
Affiliation:
Department of Pathology, Hunterian Institute, Royal College of Surgeons of England, Lincoln's Inn Fields, London WC2A 3PN
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Summary

Infection with Plasmodium vivax was established in splenectomized Callithrix jacchus marmosets by inoculation of parasitized blood from Aotus trivirgatus carrying the Vietnam Palo-Alto line of P. vivax. Subsequent blood passage through intact marmosets resulted in higher peak parasitaemias (about 1% of red cells infected) and the loss of stainable Schüffner's dots in infected cells. Primary infections with the adapted line were patent for 74 days or more, and induced both a substantial antibody response, as determined by indirect fluorescence, and some lymphocytosis, but no marked anaemia. Marmosets which had recovered from their primary infection (or in which it was drug-cured) suffered abbreviated patency with low-grade parasitaemia on re-infection.

Type
Research Article
Information
Parasitology , Volume 96 , Issue 2 , April 1988 , pp. 241 - 250
Copyright
Copyright © Cambridge University Press 1988

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References

REFERENCES

Aley, S. B., Sherwood, J. A. & Howard, R. J. (1984). Knob positive and knob negative Plasmodium falciparum differ in expression of a strain specific malarial antigen on the surface of infected erythrocytes. Journal of Experimental Medicine 160, 1585–90.CrossRefGoogle ScholarPubMed
Campbell, C. C., Collins, W. E., Chin, W., Roberts, J. M. & Broderson, J. R. (1983). Studies of the Sal 1 strain of Plasmodium vivax in the squirrel monkey (Saimiri sciureus). Journal of Parasitology 69, 598–601.Google Scholar
Coatney, G. R., Collins, W. E., Warren, McW. & Contacos, P. G. (1971). The Primate Malarias. Washington DC: U.S. Department of Health, Education and Welfare.Google Scholar
Collins, W. E., Skinner, J. C., Broderson, J. R., Mehaffey, P. C. & Sutton, B. B. (1985). Infection of Aotus azarae boliviensis monkeys with different strains of Plasmodium vivax. Journal of Parasitology 71, 239–43.CrossRefGoogle ScholarPubMed
Crawford, D. (1986). Use of the virus to prepare human derived monoclonal antibodies. In The Epstein-Barr Virus: Recent Advances (ed. Epstein, M. A. and Achong, B. E.), pp. 252–69. London: Heinemann.Google Scholar
Deane, L. M. (1967). Monkey malaria in Brazil. A summary of studies performed in 1964–1966. Revista Brasileira de Biologia 27, 213–28.Google Scholar
Desgranges, C., Lenoir, G., De, Thé, G., Seigneurin, J. M., Hilgers, J. & Dubouch, P. (1976). In vitro transforming activity of EBV I: Establishment and properties of the two EBV strains (M81 & M72) produced by immortalised Callithrix jacchus lymphocytes. Biomedicine 25, 349–53.Google Scholar
Garnham, P. C. C. (1966). Malaria Parasites and Other Haemosporidia. Oxford: Blackwell Scientific Publications.Google Scholar
Geiman, Q. M. & Meagher, M. J. (1967). Susceptibility of a new world monkey to Plasmodium falciparum from man. Nature, London 215, 437–9.CrossRefGoogle ScholarPubMed
Hawkey, C. M., Hart, M. G. & Jones, D. M. (1982). Clinical haematology of the common marmoset Callithrix jacchus. American Journal of Primatology 3, 179–99.Google Scholar
Johnson, G. D., Davidson, R. S., McNamee, K. C., Russell, G., Goodwin, D. & Holborow, E. J. (1982). Fading of immunofluorescence during microscopy: a study of the phenomenon and its remedy. Journal of Immunological Methods 55, 231–42.CrossRefGoogle ScholarPubMed
Kibukamusoke, J. (1984). Quartan malaria nephropathy. In Tropical Nephrology (ed. Kibukamusoke, J.), pp. 58–75. Canberra: Citforge.Google Scholar
Langhorne, J. & Cohen, S. (1979). Plasmodium knowlesi in the marmoset (Callithrix jacchus). Parasitology 78, 67–76.CrossRefGoogle ScholarPubMed
Maegraith, B. (1948). Pathological Processes in Malaria and Blackwater Fever. Oxford: Blackwell Scientific Publications.Google Scholar
Mitchell, G. H. (1987). The comparative immunobiology of Plasmodium: model systems and new technologies in malaria vaccine research. Progress in Veterinary Microbiology and Immunology 3, 112–38.Google ScholarPubMed
Sterling, C. R., Seed, T. M., Aikawa, M. & Rabbege, J. (1975). Erythrocyte membrane alterations induced by Plasmodium simium infection in Saimiri sciureus: relation to Schüffner's dots. Journal of Parasitology 61, 177–88.Google Scholar
Voller, A. (1964). Fluorescent antibody methods and their use in malaria research. Bulletin of the World Health Organization 30, 343–4.Google ScholarPubMed
Voller, A. & O'Neill, P. (1971). Immunofluorescence method suitable for large-scale application to malaria. Bulletin of the World Health Organization 45, 524–9.Google ScholarPubMed
Wedderburn, N., Mitchell, G. H. & Davies, D. R. (1985). Plasmodium brasilianum in the common marmoset, Callithrix jacchus. Parasitology 90, 573–8.Google Scholar
Young, M. D., Baerg, D. C. & Rossan, R. N. (1975). Experimental monkey hosts for human Plasmodia. Experimental Parasitology 38, 136–52.CrossRefGoogle ScholarPubMed