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Plasmodium brasilianum in the common marmoset Callithrix jacchus

Published online by Cambridge University Press:  06 April 2009

Nina Wedderburn ,
G. H. Mitchell  and
D. R. Davies
Nina Wedderburn
Affiliation:
Department of Pathology, Royal College of Surgeons of England, Lincoln's Inn Fields, London WC2A 3PN
G. H. Mitchell
Affiliation:
Department of Chemical Pathology, Guy's Hospital Medical School, St Thomas's Street, London SE1 9RT
D. R. Davies
Affiliation:
Department of Histopathology, St Thomas's Hospital, Lambeth Palace Road, London SE1 7EH
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Extract

Chronic quartan malarial infection has been established in the common marmoset (Callithrix jacchius). Plasniodium brasilianunm from a douroucouli monkey (Aotus trivirgatus) was used to infect splenectomized twin animals, passed to an intact animal, and then to 4 other intact adults, 2 pairs of twins. In 2 of the 4 latter animals there was continuing patency with parasitaemias of ≤0·5% parasitized erythrocytes for 30 weeks. The other 2 had lower initial levels of paraaitaemia; in 1 of these parasitaemias remained low or subpatent. All marmosets developed lymphocytosis. One animal became ill 30 weeks after infection with anaemia, weight loss and mild proteinurea, the other 3 remained well. Histological examination showed minor changes in the kidneys; spleens of infected animals showed marked follicular hyperplasia and phagocytosis of pigment. The livers showed sinusoidal hyper cellularity and pigment deposition and in splenectomized animals, a marked lymphoid follicular hyperplasia in the portal tracts.

Type
Research Article
Information
Parasitology , Volume 90 , Issue 3 , June 1985 , pp. 573 - 578
Copyright
Copyright © Cambridge University Press 1985

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