Hostname: page-component-cd9895bd7-dk4vv Total loading time: 0 Render date: 2024-12-26T00:24:17.193Z Has data issue: false hasContentIssue false
  • English
  • Français

Passive transfer of resistance to mice with sera from rabbits, rats or mice vaccinated with ultraviolet-attenuated cercariae of Schistosoma japonicum

Published online by Cambridge University Press:  06 April 2009

N. A. Moloney ,
P. Hinchcliffe  and
G. Webbe
N. A. Moloney
Affiliation:
London School of Hygiene and Tropical Medicine, Winches Farm Field Station, 395 Hatfield Road, St Albans, Herts AL4 0XQ
P. Hinchcliffe
Affiliation:
London School of Hygiene and Tropical Medicine, Winches Farm Field Station, 395 Hatfield Road, St Albans, Herts AL4 0XQ
G. Webbe
Affiliation:
London School of Hygiene and Tropical Medicine, Winches Farm Field Station, 395 Hatfield Road, St Albans, Herts AL4 0XQ
Get access Rights & Permissions [Opens in a new window]

Extract

All serum transfers from donor rats or rabbits given single or multiple vaccinations of ultraviolet (u.v.)-attenuated Schistosoma japonicum cercariae conferred significant resistance against challenge to mice. Donors given 5 vaccinations, however, produced the most effective sera; rat sera giving up to 88% protection and rabbit sera up to 80%. This protective effect was species-specific and titratable. Sera from vaccinated rabbits and rats were were most effective when transferred to mice 2 h before challenge, but became progressively less effective when transferred with increasing time after challenge. These sera had no efficacy when given 6 days after challenge. Thus, sera from vaccinated rabbits and rats were effective against the early stage of migration, but did not necessarily have to act in the skin as all serum transfers were as effective against intraperitoneal as percutaneous challenge. By contrast, serum from multiply vaccinated mice had little or no protective effect when transferred to mice before challenge, but conferred 62% resistance when transferred 5 days after challenge. Further, there was an additive protective effect when vaccinated rat and mouse sera were given in combination at their optimum transfer times (days 0 and +5, respectively). Thus, there appears to be a stage-specific immune response induced by vaccination depending upon whether the vaccinated hosts are truly permissive or not. Vaccinated rats and rabbits respond to the early phase of migration and vaccinated mice make protective responses against the lung phase of migration.

Type
Research Article
Information
Parasitology , Volume 94 , Issue 3 , June 1987 , pp. 497 - 508
Copyright
Copyright © Cambridge University Press 1987

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bickle, Q. D., Andrews, B. J., Doenhoff, M. J., Ford, M. J. & Taylor, M. G. (1985). Resistance against Schistosoma mansoni induced by highly irradiated infections: studies on species specificity of immunization and attempts to transfer resistance. Parasitology 90, 301–12.CrossRefGoogle ScholarPubMed
Dean, D. A. (1983). A review. Schistosoma and related genera: Acquired resistance in mice. Experimental Parasitology 55, 1–104.CrossRefGoogle ScholarPubMed
Ford, M. J., Bickle, Q. D. & Taylor, M. G. (1984 a). Immunization of rats against Schistosoma mansoni using irradiated cercariae, lung schistosomula and liver-stage worms. Parasitology 89, 327–44.CrossRefGoogle ScholarPubMed
Ford, M. J., Bickle, Q. D., Taylor, M. G. & Andrews, B. J. (1984 b). Passive transfer of resistance and the site of immune-dependent elimination of the challenge infection in rats vaccinated with highly irradiated cercariae of Schistosoma mansoni. Parasitology 89, 461–82.CrossRefGoogle ScholarPubMed
Hsün, H. Y. (1963). On the host specificity of Schistosoma japonicum. Chinese Medical Journal 82, 403–14.Google Scholar
Mangold, B. L. & Dean, D. A. (1986). Passive transfer with serum and IgG antibodies of irradiated cercariae induced resistance against Schistosoma mansoni in mice. Journal of Immunology 136, 2644–8.CrossRefGoogle ScholarPubMed
Moloney, N. A., Bickle, Q. D. & Webbe, G. (1985). The induction of specific immunity against Schistosoma japonicum by the exposure of mice to ultraviolet attenuated cercariae. Parasitology 90, 313–23.CrossRefGoogle ScholarPubMed
Moloney, N. A. & Webbe, G. (1983). The host-parasite relationship of Schistosoma japonicum in CBA mice. Parasitology 87, 327–42.CrossRefGoogle ScholarPubMed
Moloney, N. A. & Webbe, G. (1984). Factors affecting the acquisition of resistance to Schistosoma japonicum in the mouse. II. Evidence that resistance to reinfection is not mediated by specific effector mechanisms. Parasitology 89, 361–7.CrossRefGoogle Scholar
Moloney, N. A., Webbe, G. & Hinchcliffe, P. (1987). The induction of species-specific immunity against Schistosoma japonicum by exposure of rats to ultraviolet attenuated cercariae. Parasitology 94, 49–54.CrossRefGoogle Scholar
Moloney, N. A., Webbe, G. & Luty, A. J. (1984). Factors affecting the acquisition of resistance to Schistosoma japonicum in the mouse. I. The correlation between egg deposition and worm elimination. Parasitology 89, 345–60.CrossRefGoogle ScholarPubMed
Sadun, E. H. (1963). Immunization in schistosomiasis by previous exposure to homologous and heterologous cercariae by inoculation of preparations from schistosomes and by exposure to irradiated cercariae. Annals of the New York Academy of Sciences 113, 418–39.CrossRefGoogle ScholarPubMed
Usawattanakul, W., Kamijo, T. & Kojima, S. (1982). Comparison of recovery of schistosomula of Schistosoma japonicum from lungs of mice and rats. Journal of Parasitology 68, 783–90.CrossRefGoogle ScholarPubMed